Abstract
This study assesses the effect of extent of resection (EOR) on the longer-term survival and early mortality of elderly patients (≥ 75 years old) with glioblastoma. We used the Surveillance, Epidemiology, and End Results (SEER) database and data from our center to evaluate the effect of EOR on the long-term survival and early mortality of patients with glioblastoma. We included 50 elderly patients (≥ 75 years old) with glioblastoma visiting our hospital. The median overall survival of the patients who underwent a gross total resection, a subtotal resection, and a partial resection were 278, 200, and 83 days, respectively. The multivariate analysis showed that gross total resection (HR: 0.100; 95% CI: 0.015–0.671, p < 0.001) and subtotal reresection (HR: 0.134, 95% CI: 0.022–0.831, p < 0.001) were independent predictors of favorable prognosis when compared with partial resection. The data extracted from the SEER database also indicated that EOR was an independent predictor of OS, CCS, and early mortality. The stratification analysis revealed that gross total resection was the best protective factor of OS, early mortality, and CCS. Radical resection may improve the OS and CCS of glioblastoma patients aged ≥ 75 years and decrease early mortality.
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The data used and/or analyzed during the current study are available from the corresponding author on reasonable request.
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Yongzhong Cheng designed the study and supervised the research work. Tengfei Li and Yanhui Liu collected data. Xingwang Zhou, Tengfei Li, and Wanchun Yang did the statistical analysis. Tengfei Li wrote the article and Yongzhong Cheng revised it.
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Li, T., Liu, Y., Li, J. et al. Do elderly patients (≥ 75 years old) with glioblastoma benefit from more radical surgeries in the era of temozolomide?. Neurosurg Rev 45, 741–750 (2022). https://doi.org/10.1007/s10143-021-01600-7
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DOI: https://doi.org/10.1007/s10143-021-01600-7