Abstract
(1) To study the overall outcomes of patients surgically treated for large/giant vestibular schwannomas (VSs) and (2) to identify and analyze preoperative and intraoperative prognostic factors influencing facial nerve (FN) outcome. A retrospective clinical study was conducted at a quaternary referral otology and skull-base center. A total of 389 cases were enrolled. The inclusion criteria were patients with tumor > 30 mm undergoing surgery with a minimum follow-up of 12 months. Neurofibromatosis-II, previous radiotherapy, revision surgeries, preoperative FN House-Brackmann (HB) grade > I, partial resections, incomplete records, or those lost to follow-up for a minimum period of 1 year were excluded. In addition, partial resections and cases where FN was sacrificed intraoperatively were also excluded and were analyzed separately. The mean duration of symptoms was 35.4 months, pronounced more in elderly (58.3 months) than in younger individuals (28.4 months). Mean tumor diameter was 36 mm and 52.7% was cystic. Total resection (TR), near total resection (NTR), and subtotal resections (STR) were achieved in 77.4%, 9.5%, and 13.2% of cases, respectively. Regrowth was observed only after STR (19.6%). Good (HB I-II), moderate (HB III), and poor (HB IV-VI) FN functions were observed in 36.8%, 51.7%, and 11.6% cases, respectively. Younger individuals underwent TR in 259 (86.9%) cases against 42 (46.2%) in elderly individuals. Non-total resections (NTR/STR) were performed in 49 (53.8%) cases in elderly as against 39(13.1%) in younger individuals. Good FN outcome was observed in 28 (57.1%) cases of non-total resections in elderly as against 13 (33.3%) cases in younger individuals. On multiple logistic regression analysis, size of the tumor, preoperatively prolonged duration of symptoms, profound deafness, and antero-superiorly located FN with respect to the tumor played a detrimental role in the final facial nerve outcome postoperatively. On the contrary, in large tumors (3–3.9 cm), presence of vertigo/disequilibrium had a relatively better impact on final FN outcome. Partial resections accounted for 41(7.8%) cases and FN was interrupted in 71(13.6%) cases in total. Factors detrimental to better FN outcome were giant VSs (> 4 cm), antero-superiorly located FN intratumorally, preoperatively prolonged duration of symptoms, and profound deafness. In large tumors (3–3.9 cm), presence of vertigo/disequilibrium had a better impact on FN outcome. Understandably, cases with TR in comparison with NTR/STR had worse FN outcomes. In comparison with younger patients, elderly patients underwent higher NTR/STR resulting in better FN outcomes. The above factors can be used as prognosticators for patient counseling and surgical decision making.
References
Anaizi AN, Gantwerker EA, Pensak ML, Theodosopoulos PV (2014) Facial nerve preservation surgery for koos grade 3 and 4 vestibular schwannomas. Neurosurgery 75:671–675; discussion 676-677; quiz 677. https://doi.org/10.1227/NEU.0000000000000547
Anderson DE, Leonetti J, Wind JJ, Cribari D, Fahey K (2005) Resection of large vestibular schwannomas: facial nerve preservation in the context of surgical approach and patient-assessed outcome. J Neurosurg 102:643–649. https://doi.org/10.3171/jns.2005.102.4.0643
Angeli RD, Ben Ammar M, Sanna M (2011) Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: outcomes for 123 patients. Acta Otolaryngol 131:1237–1238. https://doi.org/10.3109/00016489.2011.596161
Angeli RD, Piccirillo E, Di Trapani G, Sequino G, Taibah A, Sanna M (2011) Enlarged translabyrinthine approach with transapical extension in the management of giant vestibular schwannomas: personal experience and review of literature. Otol Neurotol 32:125–131. https://doi.org/10.1097/MAO.0b013e3181ff7562
Ben Ammar M, Piccirillo E, Topsakal V, Taibah A, Sanna M (2012) Surgical results and technical refinements in translabyrinthine excision of vestibular schwannomas: the Gruppo Otologico experience. Neurosurgery 70:1481–1491; discussion 1491. https://doi.org/10.1227/NEU.0b013e31824c010f
Boublata L, Belahreche M, Ouchtati R, Shabhay Z, Boutiah L, Kabache M, Nadji M, Djenna Z, Bounecer H, Ioualalen N (2017) Facial nerve function and quality of resection in large and giant vestibular schwannomas surgery operated by retrosigmoid transmeatal approach in semi-sitting position with intraoperative facial nerve monitoring. World Neurosurg 103:231–240. https://doi.org/10.1016/j.wneu.2017.02.053
Brackmann DE (1991) Acoustic neuroma: surgical approaches and complications. Ann Acad Med Singap 20:674–679
Charabi S, Tos M, Borgesen SE, Thomsen J (1994) Cystic acoustic neuromas. Results of translabyrinthine surgery. Arch Otolaryngol--Head Neck Surg 120:1333–1338. https://doi.org/10.1001/archotol.1994.01880360031006
Charpiot A, Tringali S, Zaouche S, Ferber-Viart C, Dubreuil C (2010) Perioperative complications after translabyrinthine removal of large or giant vestibular schwannoma: outcomes for 123 patients. Acta Otolaryngol 130:1249–1255. https://doi.org/10.3109/00016481003762316
Chen Z, Prasad SC, Di Lella F, Medina M, Piccirillo E, Taibah A, Russo A, Yin S, Sanna M (2014) The behavior of residual tumors and facial nerve outcomes after incomplete excision of vestibular schwannomas. J Neurosurg 120:1278–1287. https://doi.org/10.3171/2014.2.JNS131497
Chitkara N, Chanda R, Yadav SP, Sharma NK (2002) Cystic acoustic neuromas. Indian J Otolaryngol Head Neck Surg 54:57–59. https://doi.org/10.1007/BF02911010
Cushing H (1917 ) Tumors of the nervus acusticus and the syndrome of the cerebellopontine angle. WB Saunders, Philadelphia
Dandinarasaiah M, Grinblat G, Prasad SC, Taibah A, Sanna M (2018) Rapidly growing cystic vestibular schwannoma with sudden onset facial palsy, ten years after subtotal excision. Laryngoscope 128:1649–1652. https://doi.org/10.1002/lary.26768
Dandinarasaiah M, Prasad SC, Piccirillo E, Vashishth A, Valentina M, Grinblat G, Codreanu CM, Sanna M (2019) Facial nerve outcomes following total excision of vestibular schwannoma by the enlarged translabyrinthine approach. Otol Neurotol 40:226–235. https://doi.org/10.1097/MAO.0000000000002068
Dandy W (1925) An operation for the total removal of cerebellopontile (acoustic) tumors. Surg Gynecol Obstet 41:129–148
Delgado T, Bucheit W, Rosenholtz H, Chrissian S (1979) Intraoperative monitoring of facial muscle evoked responses obtained by intracranial stimulation of the facial nerve: a more accurate technique for facile nerve dissection. Neurosurgery 4:418–421
Esquia-Medina GN, Grayeli AB, Ferrary E, Tubach F, Bernat I, Zhang Z, Bianchi C, Kalamarides M, Sterkers O (2009) Do facial nerve displacement pattern and tumor adhesion influence the facial nerve outcome in vestibular schwannoma surgery? Otol Neurotol 30:392–397. https://doi.org/10.1097/MAO.0b013e3181967874
Falcioni M, Fois P, Taibah A, Sanna M (2011) Facial nerve function after vestibular schwannoma surgery. J Neurosurg 115:820–826. https://doi.org/10.3171/2011.5.jns101597
House W (1964) Transtemporal bone microsurgical removal of acoustic neuromas: report of cases. Arch Otolaryngol--Head Neck Surg 80:617–667
House WF, Hitselberger WE (1985) The neuro-otologist's view of the surgical management of acoustic neuromas. Clin Neurosurg 32:214–222
Huang X, Xu J, Xu M, Chen M, Ji K, Ren J, Zhong P (2017) Functional outcome and complications after the microsurgical removal of giant vestibular schwannomas via the retrosigmoid approach: a retrospective review of 16-year experience in a single hospital. BMC Neurol 17:18. https://doi.org/10.1186/s12883-017-0805-6
Iwai Y, Yamanaka K, Ishiguro T (2003) Surgery combined with radiosurgery of large acoustic neuromas. Surg Neurol 59:283–289; discussion 289-291. https://doi.org/10.1016/s0090-3019(03)00025-9
Jacob A, Robinson LL Jr, Bortman JS, Yu L, Dodson EE, Welling DB (2007) Nerve of origin, tumor size, hearing preservation, and facial nerve outcomes in 359 vestibular schwannoma resections at a tertiary care academic center. Laryngoscope 117:2087–2092. https://doi.org/10.1097/MLG.0b013e3181453a07
Jung S, Kang SS, Kim TS, Kim HJ, Jeong SK, Kim SC, Lee JK, Kim JH, Kim SH, Lee JH (2000) Current surgical results of retrosigmoid approach in extralarge vestibular schwannomas. Surg Neurol 53:370–377; discussion 377-378. https://doi.org/10.1016/s0090-3019(00)00196-8
Kanzaki J, Tos M, Sanna M, Moffat DA, Monsell EM, Berliner KI (2003) New and modified reporting systems from the consensus meeting on systems for reporting results in vestibular schwannoma. Otol Neurotol 24:642–648; discussion 648-649. https://doi.org/10.1097/00129492-200307000-00019
Liu SW, Jiang W, Zhang HQ, Li XP, Wan XY, Emmanuel B, Shu K, Chen JC, Chen J, Lei T (2015) Intraoperative neuromonitoring for removal of large vestibular schwannoma: facial nerve outcome and predictive factors. Clin Neurol Neurosurg 133:83–89. https://doi.org/10.1016/j.clineuro.2015.03.016
Lunsford LD, Bowden G (2017) The response of cystic acoustic neuromas to radiosurgery. Neurosurgery 80:119. https://doi.org/10.1093/neuros/nyw011
Mehrotra N, Behari S, Pal L, Banerji D, Sahu RN, Jain VK (2008) Giant vestibular schwannomas: focusing on the differences between the solid and the cystic variants. Br J Neurosurg 22:550–556. https://doi.org/10.1080/02688690802159031
Merkus P, Taibah A, Sequino G, Sanna M (2010) Less than 1% cerebrospinal fluid leakage in 1,803 translabyrinthine vestibular schwannoma surgery cases. Otol Neurotol 31:276–283. https://doi.org/10.1097/MAO.0b013e3181cc06ad
Moffat DA, Parker RA, Hardy DG, Macfarlane R (2014) Factors affecting final facial nerve outcome following vestibular schwannoma surgery. J Laryngol Otol 128:406–415. https://doi.org/10.1017/S0022215114000541
Monfared A, Corrales CE, Theodosopoulos PV, Blevins NH, Oghalai JS, Selesnick SH, Lee H, Gurgel RK, Hansen MR, Nelson RF, Gantz BJ, Kutz JW Jr, Isaacson B, Roland PS, Amdur R, Jackler RK (2016) Facial nerve outcome and tumor control rate as a function of degree of resection in treatment of large acoustic neuromas: preliminary report of the acoustic neuroma subtotal resection study (ANSRS). Neurosurgery 79:194–203. https://doi.org/10.1227/NEU.0000000000001162
Nakao Y, Piccirillo E, Falcioni M, Taibah A, Russo A, Kobayashi T, Sanna M (2002) Prediction of facial nerve outcome using electromyographic responses in acoustic neuroma surgery. Otol Neurotol 23:93–95. https://doi.org/10.1097/00129492-200201000-00020
Pai I, Bowman J, Thomas N, Kitchen N, Strong A, Obholzer R, Gleeson M (2011) Management of large and giant vestibular schwannomas. Skull Base 21:379–384. https://doi.org/10.1055/s-0031-1287680
Patni AH, Kartush JM (2005) Staged resection of large acoustic neuromas. Otolaryngol Head Neck Surg 132:11–19. https://doi.org/10.1016/j.otohns.2004.09.094
Piccirillo E, Wiet MR, Flanagan S, Dispenza F, Giannuzzi A, Mancini F, Sanna M (2009) Cystic vestibular schwannoma: classification, management, and facial nerve outcomes. Otol Neurotol 30:826–834. https://doi.org/10.1097/MAO.0b013e3181b04e18
Raslan AM, Liu JK, McMenomey SO, Delashaw JB Jr (2012) Staged resection of large vestibular schwannomas. J Neurosurg 116:1126–1133. https://doi.org/10.3171/2012.1.JNS111402
Russo A, Piccirillo E, De Donato G, Agarwal M, Sanna M (2003) Anterior and posterior facial nerve rerouting: a comparative study. Skull Base 13:123–130. https://doi.org/10.1055/s-2003-43322
Samii M, Matthies C (1997) Management of 1000 vestibular schwannomas (acoustic neuromas): surgical management and results with an emphasis on complications and how to avoid them. Neurosurgery 40:11–21; discussion 21-13. https://doi.org/10.1097/00006123-199701000-00002
Samii M, Gerganov VM, Samii A (2010) Functional outcome after complete surgical removal of giant vestibular schwannomas. J Neurosurg 112:860–867. https://doi.org/10.3171/2009.7.JNS0989
Schwartz MS, Kari E, Strickland BM, Berliner K, Brackmann DE, House JW, Friedman RA (2013) Evaluation of the increased use of partial resection of large vestibular schwanommas: facial nerve outcomes and recurrence/regrowth rates. Otol Neurotol 34:1456–1464. https://doi.org/10.1097/MAO.0b013e3182976552
Silva J, Cerejo A, Duarte F, Silveira F, Vaz R (2012) Surgical removal of giant acoustic neuromas. World Neurosurg 77:731–735. https://doi.org/10.1016/j.wneu.2011.08.019
Sinha S, Sharma BS (2008) Cystic acoustic neuromas: surgical outcome in a series of 58 patients. J Clin Neurosci 15:511–515. https://doi.org/10.1016/j.jocn.2007.01.007
Sughrue ME, Yang I, Rutkowski MJ, Aranda D, Parsa AT (2010) Preservation of facial nerve function after resection of vestibular schwannoma. Br J Neurosurg 24:666–671. https://doi.org/10.3109/02688697.2010.520761
Tang IP, Freeman SR, Rutherford SA, King AT, Ramsden RT, Lloyd SK (2014) Surgical outcomes in cystic vestibular schwannoma versus solid vestibular schwannoma. Otol Neurotol 35:1266–1270. https://doi.org/10.1097/MAO.0000000000000435
Torres R, Nguyen Y, Vanier A, Smail M, Ferrary E, Sterkers O, Kalamarides M, Bernardeschi D (2017) Multivariate analysis of factors influencing facial nerve outcome following microsurgical resection of vestibular schwannoma. Otolaryngol Head Neck Surg 156:525–533. https://doi.org/10.1177/0194599816677711
Zhang Z, Wang Z, Huang Q, Yang J, Wu H (2012) Removal of large or giant sporadic vestibular schwannomas via translabyrinthine approach: a report of 115 cases. ORL J Otorhinolaryngol Relat Spec 74:271–277. https://doi.org/10.1159/000343791
Zhang S, Liu W, Hui X, You C (2016) Surgical treatment of giant vestibular schwannomas: facial nerve outcome and tumor control. World Neurosurg 94:137–144. https://doi.org/10.1016/j.wneu.2016.06.119
Zini C, Gandolfi A (1987) Facial-nerve and vocal-cord monitoring during otoneurosurgical operations. Arch Otolaryngol--Head Neck Surg 113:1291–1293. https://doi.org/10.1001/archotol.1987.01860120037004
Acknowledgments
We thank the team of Mrs. Sathi Chakraborty, Director, Tagore Institute, Bengaluru, for agreeing to review the paper for English corrections. We also thank Dr. Shivalingappa Javali, Associate Professor, USM-KLE, International Medical College, Belgaum and Professor, Michael Hopp, Medical statistician, Tel Aviv University, Israel, for performing all the statistical work involved in the paper.
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This study is funded by all the members of the Gruppo Otologico, Italy.
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Grinblat, G., Dandinarasaiah, M., Braverman, I. et al. “Large and giant vestibular schwannomas: overall outcomes and the factors influencing facial nerve function”. Neurosurg Rev 44, 2119–2131 (2021). https://doi.org/10.1007/s10143-020-01380-6
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DOI: https://doi.org/10.1007/s10143-020-01380-6