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Application value of circulating LncRNA in diagnosis, treatment, and prognosis of breast cancer

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Abstract

Breast cancer is the malignant tumor with the highest incidence in women worldwide. It is highly heterogeneous, has a high incidence of drug resistance, recurrence, and metastasis, and is one of the malignant tumors with the highest mortality rate. The early diagnosis, treatment monitoring, and prognosis assessment of breast cancer are the key factors affecting the survival of patients. However, due to the lack of specific biomarkers, breast cancer is still an essential factor affecting women’s quality of life and physical and mental health. Long non-coding RNA can regulate various genes and different signaling pathways and plays an essential role in the occurrence and development of tumors. Recent studies have found that the abnormal expression of circulating long non-coding RNA in serum, saliva, and other biological body fluids plays a significant role in early diagnosis, pathological classification, stage, therapeutic effect monitoring, and prognosis evaluation of breast cancer. This article will review the potential application value of circulating lncRNA in breast cancer.

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Funding

This work was supported by Yunnan High-level Personnel Training Support Program (YNWR-QNBJ-2020-243) and Yunnan Province Science and Technology Program, China (grant number 202101AT070071).

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Authors and Affiliations

  1. Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming, 650500, Yunnan, China

    Ming Li, Huimin Li, Xuming Deng & Miaomiao Sheng

  2. Department of Oncology, Puer People’s Hospital, Puer, Yunnan, 665000, People’s Republic of China

    Yuan Zhao

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  1. Ming Li
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  2. Yuan Zhao
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  3. Huimin Li
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  4. Xuming Deng
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  5. Miaomiao Sheng
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Contributions

Ming Li: writing—review and editing, writing—original draft, and conceptualization. Yuan Zhao: methodology, data curation, conceptualization, and writing—original draft. Huimin Li: conceptualization. Xuming Deng: writing—review and editing and conceptualization. Miaomiao Sheng: methodology, data curation, and writing—original draft.

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Correspondence to Miaomiao Sheng.

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Li, M., Zhao, Y., Li, H. et al. Application value of circulating LncRNA in diagnosis, treatment, and prognosis of breast cancer. Funct Integr Genomics 23, 61 (2023). https://doi.org/10.1007/s10142-023-00983-8

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