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Role of MRI in the evaluation of acute pyelonephritis in a high-risk population with renal dysfunction: a prospective study

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Abstract

Aims

This study aims to evaluate the (a) accuracy of conventional and diffusion-weighted-imaging (DWI) sequences in the diagnosis of acute pyelonephritis and (b) minimum apparent diffusion coefficient (ADC) values for the diagnosis of acute pyelonephritis and the differentiation of renal abscesses from acute pyelonephritis.

Materials and methods

Ultrasound, conventional MRI sequences, and DWI were used to evaluate the kidneys in 68 patients suspected to have acute pyelonephritis. Multiple similar regions of interest (ROIs) were placed over the renal parenchyma with visually identifiable diffusion restriction, over the non-diffusion-restricted renal parenchyma of affected kidneys and over the normal kidneys. Corresponding minimum ADCs were noted for analysis. Pyelonephritis was confirmed based on clinical criteria, laboratory findings, and by resolution/development of known complications of pyelonephritis.

Result

DWI showed the highest sensitivity(100%), while DWI read with T2-weighted imaging (both being positive) showed the highest specificity(100%) for the diagnosis of acute pyelonephritis in our population with a high baseline creatinine. The minimum-ADC of the nephritic diffusion-restricted area in patients with confirmed pyelonephritis was significantly lower than the minimum-ADC in patients without pyelonephritis [(0.934 ± 0.220, mean ± SD) vs (1.804 ± 0.404) × 10−3 s/mm2] (p < 0.001). ROC cut-off of minimum-ADC for the diagnosis of acute pyelonephritis was 1.202 × 10−3 s/mm2 (area under curve 0.978). The minimum-ADC of the abscesses were significantly lower when compared to the minimum-ADC of the nephritic diffusion-restricted portion of the same kidney [(0.633 ± 0.248) vs (0.850 ± 0.191) × 10−3 s/mm2] (p < 0.001).

Conclusion

DWI is an excellent stand-alone imaging tool that can be combined with conventional sequences for the diagnosis of APN even in patients with high serum-creatinine or other contraindications to intravenous contrast. Further, ADC values can be used to differentiate between renal abscesses and uncomplicated pyelonephritis.

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Data Availability

The dataset used for this study is publicly available [32].

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Authors and Affiliations

  1. Department of Radiology, St. John’s Medical College, Koramangala, Bangalore, India

    Denver Steven Pinto, Arun George, Jovis Johny & Ravi V. Hoisala

  2. Division of Body Imaging, Jackson Memorial Hospital/ University of Miami, Miami, USA

    Denver Steven Pinto

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  1. Denver Steven Pinto
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Correspondence to Denver Steven Pinto.

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Pinto, D.S., George, A., Johny, J. et al. Role of MRI in the evaluation of acute pyelonephritis in a high-risk population with renal dysfunction: a prospective study. Emerg Radiol 30, 285–295 (2023). https://doi.org/10.1007/s10140-023-02122-z

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