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Acute disseminated encephalomyelitis in a patient with monkeypox: a case report and radiological findings

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Abstract

Monkeypox is a zoonosis caused by a double-stranded DNA virus of the Poxviridae family. It currently represents a global epidemic given its contagion reported in more than 31 previously non-endemic countries. We present the case of a 30-year-old male patient from Peru with a diagnosis of monkeypox by PCR test, who manifested an initial clinical picture of asthenia, adynamia, and odynophagia, with the appearance of pustular lesions on the lower lip and in the genital region associated with motor and sensory deficit of the lower limbs with altered state of consciousness, with subsequent findings of acute disseminated encephalitis by brain magnetic resonance imaging. This entity corresponds to an infrequent complication with only one case reported in the literature. The importance lies in knowing the possible imaging findings to suspect the diagnosis and expand the knowledge about this current disease.

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References

  1. Breman JG, Ruti K, Steniowski MV (1980) Human monkeypox, 1970–1979. Bull World Health Organ 58:165–182

    CAS  Google Scholar 

  2. Magnus P, Andersen E, Petersen K, Birch-Andersen A (2009) A pox-like disease in cynomolgus monkeys. Acta Pathologica Microbiologica Scandinavica 46(2):156–176. https://doi.org/10.1111/j.1699-0463.1959.tb00328.x

    Article  Google Scholar 

  3. Sklenovská N, Van Ranst M (2018) Emergence of monkeypox as the most important Orthopoxvirus infection in humans. Front Public Health 6. https://doi.org/10.3389/fpubh.2018.00241

  4. Guarner J, Del Río C, Malani PN (2022) Monkeypox in 2022-what clinicians need to know. JAMA 328(2):139–140. https://doi.org/10.1001/jama.2022.10802

    Article  CAS  Google Scholar 

  5. Moore MJ, Rathish B, Zahra F. Monkeypox. [Updated 2022 Jul 16]. In: Stat Pearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK574519/

  6. Murthy JM, Yangala R, Meena AK, Jaganmohan Reddy J. Acute disseminated encephalomyelitis: clinical and MRI study from South India. J Neurol Sci. 1999;165(2):133–8. Available from: https://doi.org/10.1016/s0022-510x(99)00094-5

  7. Pastula DM, Copeland MJ, Hannan MC, Rapaka S, Kitani T, Kleiner E, et al. Two cases of Monkeypox-associated encephalomyelitis - Colorado and the District of Columbia, July-august 2022. MMWR Morb Mortal Wkly Rep . 2022;71(38):1212–5. Available from: https://doi.org/10.15585/mmwr.mm7138e1

  8. Pohl D, Alper G, Van Haren K, Kornberg AJ, Lucchinetti CF, Tenembaum S, et al. Acute disseminated encephalomyelitis: updates on an inflammatory CNS syndrome. Neurología . 2016;87(9 Supplement 2):S38–45. Available from: https://doi.org/10.1212/wnl.0000000000002825.

  9. Anilkumar AC, Foris LA, Tadi P. Acute disseminated encephalomyelitis. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK430934/

  10. Singh S, Alexander M, Korah IP. Acute disseminated encephalomyelitis: MR imaging features. AJR Am J Roentgenol . 1999;173(4):1101–7. Available from: https://doi.org/10.2214/ajr.173.4.10511187

  11. Sejvar JJ, Chowdary Y, Schomogyi M, et al. Human monkeypox infection: a family cluster in the midwestern United States. J Infect Dis. 2004;190(10):1833–1840. https://doi.org/10.1086/425039.

  12. Sarbu N, Shih RY, Jones RV, Horkayne-Szakaly I, Oleaga L, Smirniotopoulos JG. White matter diseases with radiologic-pathologic correlation. Radiographics. 2016;36(5):1426–47. Available from: https://doi.org/10.1148/rg.2016160031.

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Authors and Affiliations

  1. Radiologist at Fundación Clínica Shaio, Bogotá, Colombia

    Aleyda Rodríguez

  2. Radiology Resident at Universidad de La Sabana, Chía, Colombia

    Laura C. Rodríguez

  3. Medical Student, Universidad de la Sabana, Chía, Colombia

    Nicolás Bastidas

Authors
  1. Aleyda Rodríguez
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  2. Laura C. Rodríguez
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  3. Nicolás Bastidas
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Contributions

All authors contributed to the article conception and design. The diagnosis was made by Aleyda Rodríguez. Material preparation, data collection, and analysis were performed by Laura C. Rodríguez and Nicolás Bastidas. The first draft of the manuscript was written by Nicolás Bastidas and Laura C. Rodríguez, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Nicolás Bastidas.

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This article was approved by the ethics committee of the hospital.

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Informed consent was obtained from the patient for the publication of data from her clinical history and the necessary images.

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The authors declare that they have no conflict of interest.

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Rodríguez, A., Rodríguez, L.C. & Bastidas, N. Acute disseminated encephalomyelitis in a patient with monkeypox: a case report and radiological findings. Emerg Radiol 30, 127–131 (2023). https://doi.org/10.1007/s10140-022-02108-3

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  • DOI: https://doi.org/10.1007/s10140-022-02108-3

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