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Racial disparities of gastric cancer in the USA: an overview of epidemiology, global screening guidelines, and targeted screening in a heterogeneous population

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Abstract

Gastric cancer is the fifth most common cancer diagnosis and fourth leading cause of cancer-related death globally. The incidence of gastric cancer in the USA shows significant racial and ethnic disparities with gastric cancer incidence in Korean Americans being over five times higher than in non-Hispanic whites. Since gastric cancer is not common in the USA, there are no current screening guidelines. In countries with higher incidences of gastric cancer, screening guidelines have been implemented for early detection and intervention and this has been associated with a reduction in mortality. Immigrants from high incidence countries develop gastric cancer at lower rates once outside of their country of origin, but continue to be at higher risk for developing gastric cancer. This risk does seem to decrease with subsequent generations. With increasing availability of endoscopy, initiating gastric cancer screening guidelines for high-risk groups can have the potential to improve survival by diagnosing and treating gastric cancer at an earlier stage. This article aims to provide context to gastric cancer epidemiology globally, review risk factors for developing gastric cancer, highlight racial and ethnic disparities in gastric cancer burden in the USA, examine current guidelines that exist in high incidence countries, and suggest future studies examining the efficacy of additional screening in high-risk populations to reduce gastric cancer mortality and disparate burden on ethnic minorities in the USA.

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References

  1. Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Gastroenterol Rev Gastroenterol. 2019;14(1):26–38.

    Article  CAS  Google Scholar 

  2. Ilic M, Ilic I. Epidemiology of stomach cancer. World J Gastroenterol. 2022;28(12):1187–203.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Saumoy M, Schneider Y, Shen N, Kahaleh M, Sharaiha RZ, Shah SC. Cost effectiveness of gastric cancer screening according to race and ethnicity. Gastroenterology. 2018;155(3):648–60.

    Article  PubMed  Google Scholar 

  4. Shah SC, Canakis A, Peek RM, Saumoy M. Endoscopy for gastric cancer screening is cost effective for Asian Americans in the United States. Clin Gastroenterol Hepatol. 2020;18(13):3026–39.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Pabla BS, Shah SC, Corral JE, Morgan DR. Increasing incidence and mortality of gastric cancer in immigrant populations from high to low regions of incidence—a systematic review and meta-analysis. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2020;18(2):347-359.e5.

    Google Scholar 

  6. Hallowell BD, Endeshaw M, McKenna MT, Senkomago V, Razzaghi H, Saraiya M. Cancer mortality rates among US and foreign-born individuals: United States 2005–2014. Prev Med. 2019;126: 105755.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Heightened Risk for Gastric Cancer Among Immigrant Populations in New York State From High-Incidence Countries—ClinicalKey [Internet]. https://www-clinicalkey-com.proxy.library.vanderbilt.edu/#!/content/playContent/1-s2.0-S154235652200773X?scrollTo=%23bib2. Accessed 3 Jan 2024.

  8. Dong E, Duan L, Wu BU. Racial and ethnic minorities at increased risk for gastric cancer in a Regional US Population Study. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2017;15(4):511–7.

    Google Scholar 

  9. Kendrick P, Kelly YO, Baumann MM, Compton K, Blacker BF, Daoud F, Li Z, Mouhanna F, Nassereldine H, Schmidt C, Sylte DO, Force LM, Hay SI, Rodriquez EJ, Mensah GA, Nápoles AM, Pérez-Stable EJ, Murray CJL, Mokdad AH, Dwyer-Lindgren L. The burden of stomach cancer mortality by county, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities. Lancet Reg Health Am 2023;24:100547. https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(23)00121-7/fulltext. Accessed 3 Jan 2024.

  10. Grad YH, Lipsitch M, Aiello AE. Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities. Am J Epidemiol. 2012;175(1):54–9.

    Article  PubMed  Google Scholar 

  11. Li Y, Choi H, Leung K, Jiang F, Graham DY, Leung WK. Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2023;8(6):553–64.

    Article  PubMed  Google Scholar 

  12. Sonnenberg A, Turner KO, Genta RM. Low prevalence of Helicobacter pylori-positive peptic ulcers in private outpatient endoscopy centers in the United States. Off J Am Coll Gastroenterol ACG. 2020;115(2):244.

    Article  Google Scholar 

  13. Shah SC, Halvorson AE, Lee D, Bustamante R, McBay B, Gupta R, Denton J, Dorn C, Wilson O, Peek R, Gupta S, Liu L, Hung A, Greevy R, Roumie CL. Helicobacter pylori burden in the United States according to individual demographics and geography: a nationwide analysis of the Veterans Healthcare System. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2024;22(1):42-50.e26.

    Google Scholar 

  14. Wenker TN, Peng FB, Emelogu I, Mallepally N, Kanwal F, El-Serag HB, Tan MC. The predictive performance of contemporary guideline recommendations for Helicobacter pylori testing in a United States population. Clin Gastroenterol Hepatol. 2023;21(7):1771–80.

    Article  Google Scholar 

  15. Tsai CJ, Perry S, Sanchez L, Parsonnet J. Helicobacter pylori infection in different generations of hispanics in the San Francisco Bay Area. Am J Epidemiol 2005;162(4):351–7. https://academic.oup.com/aje/article/162/4/351/105080. Accessed 3 Jan 2024.

  16. Correa P. A human model of gastric carcinogenesis. Cancer Res. 1988;48(13):3554–60.

    CAS  PubMed  Google Scholar 

  17. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology. 2007;133(2):659–72.

    Article  CAS  PubMed  Google Scholar 

  18. Uemura N, Okamoto S, Yamamoto S. H. pylori infection and the development of gastric cancer. Keio J Med. 2002;51(supplement 2):63–8.

    Article  PubMed  Google Scholar 

  19. Schistosomes, liver flukes and Helicobacter pylori. In: IARC monographs on the evaluation of carcinogenic risks to humans; 1994.

  20. Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001;49(3):347–53.

    Article  Google Scholar 

  21. Bardhan PK. Epidemiological features of Helicobacter pylori infection in developing countries. Clin Infect Dis. 1997;25(5):973–8.

    Article  CAS  PubMed  Google Scholar 

  22. Salih B. Helicobacter pylori infection in developing countries: the burden for how long? Saudi J Gastroenterol. 2009;15(3):201.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Smith JG, Li W, Rosson RS. Prevalence, clinical and endoscopic predictors of Helicobacter pylori infection in an urban population. Conn Med. 2009;73(3):133–7.

    PubMed  Google Scholar 

  24. Varga MG, Butt J, Blot WJ, Le Marchand L, Haiman CA, Chen Y, Wassertheil-Smoller S, Tinker LF, Peek RM, Potter JD, Cover TL, Hyslop T, Zeleniuch-Jacquotte A, Berndt SI, Hildesheim A, Waterboer T, Pawlita M, Epplein M. Racial differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States. Cancer Epidemiol Biomarkers Prev. 2020;29(10):2084–92.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Choi IJ, Kim CG, Lee JY, Kim YI, Kook MC, Park B, Joo J. Family history of gastric cancer and Helicobacter pylori treatment. N Engl J Med. 2020;382(5):427–36.

    Article  PubMed  Google Scholar 

  26. Hemminki K, Zhang H, Czene K. Socioeconomic factors in cancer in Sweden. Int J Cancer. 2003;105(5):692–700.

    Article  CAS  PubMed  Google Scholar 

  27. Power C, Hyppönen E, Davey SG. Socioeconomic position in childhood and early adult life and risk of mortality: a prospective study of the Mothers of the 1958 British Birth Cohort. Am J Public Health. 2005;95(8):1396–402.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Nagel G, Linseisen J, Boshuizen HC, Pera G, Del Giudice G, Westert GP, Bueno-de-Mesquita HB, Allen NE, Key TJ, Numans ME, Peeters PH, Sieri S, Siman H, Berglund G, Hallmans G, Stenling R, Martinez C, Arriola L, Barricarte A, Chirlaque MD, Quiros JR, Vineis P, Masala G, Palli D, Panico S, Tumino R, Bingham S, Boeing H, Bergmann MM, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Olsen A, Tjonneland A, Trichopoulou A, Bamia C, Soukara S, Sabourin JC, Carneiro F, Slimani N, Jenab M, Norat T, Riboli E, Gonzalez CA. Socioeconomic position and the risk of gastric and oesophageal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST). Int J Epidemiol. 2007;36(1):66–76.

    Article  PubMed  Google Scholar 

  29. Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, Lunet N. Smoking and gastric cancer: systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008;19(7):689–701.

    Article  PubMed  Google Scholar 

  30. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Personal habits and indoor combustions. IARC Monogr Eval Carcinog Risks Hum 2012;100(Pt E):1–538.

  31. Rota M, Pelucchi C, Bertuccio P, Matsuo K, Zhang Z, Ito H, Hu J, Johnson KC, Palli D, Ferraroni M, Yu G, Muscat J, Lunet N, Peleteiro B, Ye W, Song H, Zaridze D, Maximovitch D, Guevara M, Fernández-Villa T, Vioque J, Navarrete-Muñoz EM, Wolk A, Orsini N, Bellavia A, Håkansson N, Mu L, Persiani R, Kurtz RC, Lagiou A, Lagiou P, Galeone C, Bonzi R, Boffetta P, Boccia S, Negri E, La Vecchia C. Alcohol consumption and gastric cancer risk—a pooled analysis within the StoP project consortium. Int J Cancer. 2017;141(10):1950–62.

    Article  CAS  PubMed  Google Scholar 

  32. Yang P, Zhou Y, Chen B, Wan HW, Jia GQ, Bai HL, Wu XT. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009;45(16):2867–73.

    Article  PubMed  Google Scholar 

  33. Clinton SK, Giovannucci EL, Hursting SD. The World Cancer Research Fund/American Institute for Cancer Research Third Expert Report on Diet, Nutrition, Physical Activity, and Cancer: impact and future directions. J Nutr. 2020;150(4):663–71.

    Article  PubMed  Google Scholar 

  34. D’Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr. 2012;31(4):489–98.

    Article  PubMed  Google Scholar 

  35. Ge S, Feng X, Shen L, Wei Z, Zhu Q, Sun J. Association between habitual dietary salt intake and risk of gastric cancer: a systematic review of observational studies. Gastroenterol Res Pract. 2012;2012:1–11.

    Article  Google Scholar 

  36. Ren JS, Kamangar F, Forman D, Islami F. Pickled food and risk of gastric cancer—a systematic review and meta-analysis of English and Chinese literature. Cancer Epidemiol Biomarkers Prev. 2012;21(6):905–15.

    Article  PubMed  Google Scholar 

  37. Shin CM, Kim N, Yang HJ, Cho SI, Lee HS, Kim JS, Jung HC, Song IS. Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for the risk of stomach cancer. J Clin Gastroenterol. 2010;44(2):e34–9.

    Article  PubMed  Google Scholar 

  38. Rokkas T, Sechopoulos P, Pistiolas D, Margantinis G, Koukoulis G. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients: a meta-analysis. Eur J Gastroenterol Hepatol. 2010;22(9):1128–33.

    Article  PubMed  Google Scholar 

  39. Fitzgerald RC, Hardwick R, Huntsman D, Carneiro F, Guilford P, Blair V, Chung DC, Norton J, Ragunath K, Van Krieken JH, Dwerryhouse S, Caldas C, on behalf of the International Gastric Cancer Linkage Consortium. Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research. J Med Genet 2010;47(7):436–44.

  40. Shah D, Bentrem D. Environmental and genetic risk factors for gastric cancer. J Surg Oncol. 2022;125(7):1096–103.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Choi KS, Jun JK, Lee H, Park S, Jung KW, Han MA, Choi IJ, Park E. Performance of gastric cancer screening by endoscopy testing through the National Cancer Screening Program of Korea. Cancer Sci. 2011;102(8):1559–64.

    Article  CAS  PubMed  Google Scholar 

  42. National Cancer Center. Cancer Facts & Figures 2014. Goyang, KR: National Cancer Center.

  43. Jung KW, Won YJ, Kong HJ, Oh CM, Lee DH, Lee JS. Cancer Statistics in Korea: incidence, mortality, survival, and prevalence in 2011. Cancer Res Treat. 2014;46(2):109–23.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Xia JY, Aadam AA. Advances in screening and detection of gastric cancer. J Surg Oncol. 2022;125(7):1104–9.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Pabla BS, Shah SC, Corral JE, Morgan DR. Increased incidence and mortality of gastric cancer in immigrant populations from high to low regions of incidence: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020;18(2):347-359.e5.

    Article  PubMed  Google Scholar 

  46. Iwasaki M. Cancer mortality among Japanese immigrants and their descendants in the State of Sao Paulo, Brazil, 1999–2001. Jpn J Clin Oncol. 2004;34(11):673–80.

    Article  PubMed  Google Scholar 

  47. Ziadeh C, Ziogas A, Anton-Culver H. Cancer risk in different generations of Middle Eastern immigrants to California, 1988–2013. Int J Cancer. 2017;141(11):2260–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Kamineni A, Williams MA, Schwartz SM, Cook LS, Weiss NS. The incidence of gastric carcinoma in Asian migrants to the United States and their descendants. Cancer Causes Control. 1999;10(1):77–83.

    Article  CAS  PubMed  Google Scholar 

  49. Mousavi SM, Hemminki K. Cancer incidence, trends, and survival among immigrants to Sweden: a population-based study. Eur J Cancer Prev. 2015;24(Supplement 1):S1-63.

    Article  PubMed  Google Scholar 

  50. Kim Y, Park J, Nam BH, Ki M. Stomach cancer incidence rates among Americans, Asian Americans and Native Asians from 1988 to 2011. Epidemiol Health. 2015;37: e2015006.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Bray F, Ferlay J, Laversanne M, Brewster DH, Gombe Mbalawa C, Kohler B, Piñeros M, Steliarova-Foucher E, Swaminathan R, Antoni S, Soerjomataram I, Forman D. Cancer incidence in five continents: inclusion criteria, highlights from volume X and the global status of cancer registration. Int J Cancer. 2015;137(9):2060–71.

    Article  CAS  PubMed  Google Scholar 

  52. Kolonel LN, Altshuler D, Henderson BE. The multiethnic cohort study: exploring genes, lifestyle and cancer risk. Nat Rev Cancer. 2004;4(7):519–27.

    Article  CAS  PubMed  Google Scholar 

  53. Maskarinec G, Noh JJ. The effect of migration on cancer incidence among Japanese in Hawaii. Ethn Dis. 2004;14(3):431–9.

    PubMed  Google Scholar 

  54. Lee E, Liu L, Zhang J, Stern MC, Barzi A, Hwang A, Kim AE, Hamilton AS, Wu AH, Deapen D. Stomach cancer disparity among Korean Americans by tumor characteristics: comparison with non-hispanic Whites, Japanese Americans, South Koreans, and Japanese. Cancer Epidemiol Biomarkers Prev. 2017;26(4):587–96.

    Article  PubMed  Google Scholar 

  55. SEER Cancer Stat Facts: Stomach Cancer. [Internet]. Bethesda, MD; 2021. https://seer.cancer.gov/statfacts/html/stomach.html. Accessed 26 Mar 2023.

  56. Zhang X, Li M, Chen S, Hu J, Guo Q, Liu R, Zheng H, Jin Z, Yuan Y, Xi Y, Hua B. Endoscopic screening in Asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review. Gastroenterology. 2018;155(2):347-354.e9.

    Article  PubMed  Google Scholar 

  57. Kim GH, Bang SJ, Ende AR, Hwang JH. Is screening and surveillance for early detection of gastric cancer needed in Korean Americans? Korean J Intern Med. 2015;30(6):747–58.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: is it needed? Gastrointest Endosc. 2016;84(1):18–28.

    Article  PubMed  Google Scholar 

  59. Dinis-Ribeiro M, Da Costa-Pereira A, Lopes C, Barbosa J, Guilherme M, Moreira-Dias L, Lomba-Viana H, Silva R, Abreu N, Lomba-Viana R. Validity of Serum Pepsinogen I/II ratio for the diagnosis of gastric epithelial dysplasia and intestinal metaplasia during the follow-up of patients at risk for intestinal-type gastric adenocarcinoma. Neoplasia. 2004;6(5):449–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Yoshihara M, Hiyama T, Yoshida S, Ito M, Tanaka S, Watanabe Y, Haruma K. Reduction in gastric cancer mortality by screening based on serum pepsinogen concentration: a case-control study. Scand J Gastroenterol. 2007;42(6):760–4.

    Article  CAS  PubMed  Google Scholar 

  61. Sugano K. Screening of gastric cancer in Asia. Best Pract Res Clin Gastroenterol. 2015;29(6):895–905.

    Article  PubMed  Google Scholar 

  62. Kowada A. Cost-effectiveness of Helicobacter pylori test and eradication versus upper gastrointestinal series versus endoscopy for gastric cancer mortality and outcomes in high prevalence countries. Scand J Gastroenterol. 2019;54(6):685–9.

    Article  PubMed  Google Scholar 

  63. Leja M, You W, Camargo MC, Saito H. Implementation of gastric cancer screening—the global experience. Best Pract Res Clin Gastroenterol. 2014;28(6):1093–106.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Kato M, Asaka M. Recent development of gastric cancer prevention. Jpn J Clin Oncol. 2012;42(11):987–94.

    Article  PubMed  Google Scholar 

  65. Asaka M, Kato M, Takahashi S, Fukuda Y, Sugiyama T, Ota H, Uemura N, Murakami K, Satoh K, Sugano K. Guidelines for the management of Helicobacter pylori Infection in Japan: 2009 Revised Edition. Helicobacter 2010;15(1):1–20.

  66. Tashiro A, Sano M, Kinameri K, Fujita K, Takeuchi Y. Comparing mass screening techniques for gastric cancer in Japan. World J Gastroenterol. 2006;12(30):4873–4.

    PubMed  PubMed Central  Google Scholar 

  67. Wolfsen HC, Hemminger LL, Achem SR, Loeb DS, Stark ME, Bouras EP, DeVault KR. Complications of endoscopy of the upper gastrointestinal tract: a single-center experience. Mayo Clin Proc. 2004;79(10):1264–7.

    Article  PubMed  Google Scholar 

  68. Abe Y, Mitsushima T, Nagatani K, Ikuma H, Minamihara Y. Epidemiological evaluation of the protective effect for dying of stomach cancer by screening programme for stomach cancer with applying a method of case-control study—a study of a efficient screening programme for stomach cancer. Nihon Shokakibyo Gakkai Zasshi Jpn J Gastro-Enterol. 1995;92(5):836–45.

    CAS  Google Scholar 

  69. Shizuyo I, Hiroshi H, Chisato N, Yoko K, Naoyoshi T, Norito K, Hiroyuki S. Evaluation of a screening program on reduction of gastric cancer mortality in Japan: preliminary results from a cohort study. Prev Med. 1999;29(2):102–6.

    Article  Google Scholar 

  70. Fukao A, Tsubono Y, Tsuji I, Hisamichi S, Sugahara N, Takano A. The evaluation of screening for gastric cancer in Miyagi prefecture, Japan: a population-based case-control study. Int J Cancer. 1995;60(1):45–8.

    Article  CAS  PubMed  Google Scholar 

  71. Yashima K, Shabana M, Kurumi H, Kawaguchi K, Isomoto H. Gastric cancer screening in Japan: a narrative review. J Clin Med. 2022;11(15):4337.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  72. Kim Y, Jun JK, Choi KS, Lee HY, Park EC. Overview of the National Cancer Screening Programme and the cancer screening status in Korea. Asian Pac J Cancer Prev. 2011;12(3):725–30.

    PubMed  Google Scholar 

  73. Kim YG, Kong SH, Oh SY, Lee KG, Suh YS, Yang JY, Choi J, Kim SG, Kim JS, Kim WH, Lee HJ, Yang HK. Effects of screening on gastric cancer management: comparative analysis of the results in 2006 and in 2011. J Gastric Cancer. 2014;14(2):129.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Cho E, Kang MH, Choi KS, Suh M, Jun JK, Park EC. Cost-effectiveness outcomes of the National Gastric Cancer Screening Program in South Korea. Asian Pac J Cancer Prev. 2013;14(4):2533–40.

    Article  PubMed  Google Scholar 

  75. Lee HY. Comparing upper gastrointestinal X-ray and endoscopy for gastric cancer diagnosis in Korea. World J Gastroenterol. 2010;16(2):245.

    Article  PubMed  PubMed Central  Google Scholar 

  76. Chang HS, Park EC, Chung WJ, Nam CM, Choi KS, Cho E, Cho WH. Comparing endoscopy and upper gastrointestinal X-ray for gastric cancer screening in South Korea: a cost-utility analysis. Asian Pac J Cancer Prev. 2012;13(6):2721–8.

    Article  PubMed  Google Scholar 

  77. Choi KS, Jun JK, Park EC, Park S, Jung KW, Han MA, Choi IJ, Lee HY. Performance of different gastric cancer screening methods in Korea: a population-based study. PLoS ONE. 2012;7(11): e50041.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Torres J, Correa P, Ferreccio C, Hernandez-Suarez G, Herrero R, Cavazza-Porro M, Dominguez R, Morgan D. Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America. Cancer Causes Control. 2013;24(2):249–56.

    Article  PubMed  Google Scholar 

  79. Pisani P, Oliver W, Parkin D, Alvarez N, Vivas J. Case-control study of gastric cancer screening in Venezuela. Br J Cancer. 1994;69(6):1102–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  80. Rosero-Bixby L, Sierra R. X-ray screening seems to reduce gastric cancer mortality by half in a community-controlled trial in Costa Rica. Br J Cancer. 2007;97(7):837–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Sierra MS, Cueva P, Bravo LE, Forman D. Stomach cancer burden in Central and South America. Cancer Epidemiol. 2016;44:S62-73.

    Article  PubMed  Google Scholar 

  82. Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359. https://doi.org/10.1002/ijc.29210.

    Article  CAS  PubMed  Google Scholar 

  83. Chey WD, Leontiadis GI, Howden CW, Moss SF. ACG clinical guideline: treatment of Helicobacter pylori infection. Am J Gastroenterol. 2017;112(2):212–39.

    Article  PubMed  Google Scholar 

  84. Murakami TT, Scranton RA, Brown HE, Harris RB, Chen Z, Musuku S, Oren E. Management of Helicobacter pylori in the United States: results from a national survey of gastroenterology physicians. Prev Med. 2017;100:216–22.

    Article  PubMed  Google Scholar 

  85. El-Serag HB, Kao JY, Kanwal F, Gilger M, LoVecchio F, Moss SF, Crowe SE, Elfant A, Haas T, Hapke RJ, Graham DY. Houston consensus conference on testing for Helicobacter pylori infection in the United States. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2018;16(7):992-1002.e6.

    Google Scholar 

  86. Huang RJ, Epplein M, Hamashima C, Choi IJ, Lee E, Deapen D, Woo Y, Tran T, Shah SC, Inadomi JM, Greenwald DA, Hwang JH. An approach to the primary and secondary prevention of gastric cancer in the United States. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2022;20(10):2218-2228.e2.

    Google Scholar 

  87. Choi CE, Sonnenberg A, Turner K, Genta RM. High prevalence of gastric preneoplastic lesions in East Asians and Hispanics in the USA. Dig Dis Sci. 2015;60(7):2070–6.

    Article  PubMed  Google Scholar 

  88. Chiang TH, Chang WJ, Chen SLS, Yen AMF, Fann JCY, Chiu SYH, Chen YR, Chuang SL, Shieh CF, Liu CY, Chiu HM, Chiang H, Shun CT, Lin MW, Wu MS, Lin JT, Chan CC, Graham DY, Chen HH, Lee YC. Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands. Gut. 2021;70(2):243–50.

    CAS  PubMed  Google Scholar 

  89. Fendrick AM. The role of economic evaluation in the diagnosis and treatment of Helicobacter pylori infection. Gastroenterol Clin North Am. 2000;29(4):837–51.

    Article  CAS  PubMed  Google Scholar 

  90. Parsonnet J, Harris RA, Hack HM, Owens DK. Modelling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials. Lancet. 1996;348(9021):150–4.

    Article  CAS  PubMed  Google Scholar 

  91. Harris RA, Owens DK, Witherell H, Parsonnet J. Helicobacter pylori and gastric cancer: what are the benefits of screening only for the CagA phenotype of H. pylori? Helicobacter 1999;4(2):69–76.

  92. Davies R, Crabbe D, Roderick P, Goddard JR, Raftery J, Patel P. A simulation to evaluate screening for Helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers. 2002. p. 249–58. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036831231&doi=10.1023%2fA%3a1020326005465&partnerID=40&md5=ab6eaa0ce7a252bd8b26aaad2356b11e

  93. Mason J, Axon ATR, Forman D, Duffett S, Drummond M, Crocombe W, Feltbower R, Mason S, Brown J, Moayyedi P. The cost-effectiveness of population Helicobacter pylori screening and treatment: a Markov model using economic data from a randomized controlled trial. Aliment Pharmacol Ther. 2002;16(3):559–68.

    Article  CAS  PubMed  Google Scholar 

  94. Roderick P, Davies R, Raftery J, Crabbe D, Pearce R, Bhandari P, Patel P. The cost-effectiveness of screening for Helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model. Health Technol Assess Winch Engl. 2003;7(6):1–86.

    CAS  Google Scholar 

  95. Xie F, O’Reilly D, Ferrusi IL, Blackhouse G, Bowen JM, Tarride JE, Goeree R. Illustrating economic evaluation of diagnostic technologies: comparing Helicobacter pylori screening strategies in prevention of gastric cancer in Canada. J Am Coll Radiol. 2009;6(5):317–23.

    Article  PubMed  Google Scholar 

  96. Teng AM, Kvizhinadze G, Nair N, McLeod M, Wilson N, Blakely T. A screening program to test and treat for Helicobacter pylori infection: cost-utility analysis by age, sex and ethnicity. BMC Infect Dis. 2017;17(1):156. https://doi.org/10.1186/s12879-017-2259-2.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Lansdorp-Vogelaar I, Meester RGS, Laszkowska M, Escudero FA, Ward ZJ, Yeh JM. Cost-effectiveness of prevention and early detection of gastric cancer in Western countries. Best Pract Res Clin Gastroenterol. 2021;50–51: 101735.

    Article  PubMed  Google Scholar 

  98. Gupta N, Bansal A, Wani SB, Gaddam S, Rastogi A, Sharma P. Endoscopy for upper GI cancer screening in the general population: a cost-utility analysis. Gastrointest Endosc. 2011;74(3):610-624.e2.

    Article  PubMed  Google Scholar 

  99. Yeh JM, Hur C, Ward Z, Schrag D, Goldie SJ. Gastric adenocarcinoma screening and prevention in the era of new biomarker and endoscopic technologies: a cost-effectiveness analysis. Gut. 2016;65(4):563–74.

    Article  CAS  PubMed  Google Scholar 

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  1. Jean Woo Mok and Yeong Ha Oh have contributed equally to this work.

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  1. Vanderbilt University School of Medicine, Nashville, TN, USA

    Jean Woo Mok & Yeong Ha Oh

  2. Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    Deepa Magge & Sekhar Padmanabhan

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  1. Jean Woo Mok
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Mok, J.W., Oh, Y.H., Magge, D. et al. Racial disparities of gastric cancer in the USA: an overview of epidemiology, global screening guidelines, and targeted screening in a heterogeneous population. Gastric Cancer 27, 426–438 (2024). https://doi.org/10.1007/s10120-024-01475-9

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