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Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications

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Abstract

Hybrids, produced by hybridization of proteins, peptides, DNA, and other new biomolecules with polymers, often have unique functional properties. These properties, such as biocompatibility, stability and specificity, lead to various smart biomaterials. This review mainly introduces biomolecule-polymer hybrid materials by reversible deactivation radical polymerization (RDRP), emphasizing reverse addition-fragmentation chain transfer (RAFT) polymerization, and nitroxide mediated polymerization (NMP). It includes the methods of RDRP to improve the biocompatibility of biomedical materials and organisms by surface modification. The key to the current synthesis of biomolecule-polymer hybrids is to control polymerization. Besides, this review describes several different kinds of biomolecule-polymer hybrid materials and their applications in the biomedical field. These progresses provide ideas for the investigation of biodegradable and highly bioactive biomedical soft tissue materials. The research hotspots of nanotechnology in biomedical fields are controlled drug release materials and gene therapy carrier materials. Research showed that RDRP method could improve the therapeutic effect and reduce the dosage and side effects of the drug. Specifically, by means of RDRP, the original materials can be modified to develop intelligent polymer materials as membrane materials with selective permeability and surface modification.

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Acknowledgments

ZQS acknowledges the financial supports from the National Natural Science Foundation of China (NSFC, No. 51873016), the Fundamental Research Funds for the Central Universities (No. JD2014), and the Joint Project of BRC-BC (Biomedical Translational Engineering Research Center of BUCT-CJFH) (No. XK2020-11).

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  1. State Key Laboratory of Chemical Resource Engineering, Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing, 100029, China

    Jie Zhou, Xiao-Yuan Zhang & Zhi-Qiang Su

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  1. Jie Zhou
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  2. Xiao-Yuan Zhang
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  3. Zhi-Qiang Su
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Correspondence to Xiao-Yuan Zhang or Zhi-Qiang Su.

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Biographies

Xiao-Yuan Zhang received her M.Sc. in polymer materials and engineering from Beijing University of Chemical Technology, China, in 2013. She completed her Ph.D. candidate in Jandt group at the Otto Schott Institute of Materials Research, Friedrich Schiller University Jena, Germany. Currently, she is working at Beijing University of Chemical Technology. Her research focuses on nanostructured polymer surfaces and their effect on protein adsorption and cellular response.

Zhi-Qiang Su completed his PhD in 2005 at Institute of Chemistry, Chinese Academy of Sciences. After a postdoctoral fellow at Tsinghua University, he joined Beijing University of Chemical Technology in 2007. In 2011 he studied at Friedrich-Schiller-University Jena, Germany, as an experienced research fellow of the Alexander-von-Humboldt Foundation. In 2012, he was appointed a full professor. His research covers a wide range of research fields including nano-hybrid materials, biomedical materials, biosensors and bioelectronics. So far, he has published more than 100 papers in international peer-reviewed journals. The published papers have been cited more than 5000 times with an H-index of 43.

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Zhou, J., Zhang, XY. & Su, ZQ. Rational Design of Biomolecules/Polymer Hybrids by Reversible Deactivation Radical Polymerization (RDRP) for Biomedical Applications. Chin J Polym Sci 39, 1093–1109 (2021). https://doi.org/10.1007/s10118-021-2543-x

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