Skip to main content
SpringerLink
Log in

Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release

  • Papers
  • Published:
Chinese Journal of Polymer Science Aims and scope Submit manuscript

Abstract

Microspheres with thermo-responsible surface were fabricated by PCL-b-PEO-b-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-b-PEO-b-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (e.g. 37 °C) were observed from porous surface structure to compact surface layer. Enzymatic degradation and in vitro drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-b-PEO copolymers, the drug release could be well regulated by changing temperatures and microspheres composition, which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Karatas, A., Sonakin, O., Kilicarslan, M. and Baykara, T., J. Microencapsul, 2009, 26: 63

    Article  CAS  Google Scholar 

  2. Hombreiro-Perez, M., Siepmann, J., Zinutti, C., Lamprecht, A., Ubrich, N., Hoffman, M., Bodmeier, R. and Maincent, P., J. Control. Release, 2003, 88: 413

    Article  CAS  Google Scholar 

  3. Fernandez-Carballido, A., Herrero-Vanrell, R., Molina-Martinez, I.T. and Pastoriza, P., Int. J. Pharm., 2004, 279: 33

    Article  CAS  Google Scholar 

  4. Viswanathan, N.B., Thomas, P.A., Pandit, J.K., Kulkarni, M.G. and Mashelkar, R.A., J. Control. Release, 1999, 58: 9

    Article  CAS  Google Scholar 

  5. ODonnell, P.B. and McGinity, J.W., Adv. Drug Deliver. Rev., 1997, 28: 25

    Article  CAS  Google Scholar 

  6. Liu, R., Ma, G.H., Meng, F.T. and Su, Z.G., J. Control. Release, 2005, 103: 31

    Article  CAS  Google Scholar 

  7. Liu, R., Ma, G.H., Wan, Y.H. and Su, Z.G., Colloids Surf. B, 2005, 45: 144

    Article  CAS  Google Scholar 

  8. Zheng, W., Int. J. Pharm., 2009, 374: 90

    Article  CAS  Google Scholar 

  9. Yu, G.Q., Shi, X.D. and Gan, Z.H., Acta Polymerica Sinica (in Chinese), 2006, (5): 740

    Google Scholar 

  10. Wang, F.J. and Wang, C.H., J. Biomat. Sci-Polym. E, 2003, 14: 157

    Article  CAS  Google Scholar 

  11. Sansdrap, P. and Moes, A.J., Int. J. Pharm., 1993, 98: 157

    Article  CAS  Google Scholar 

  12. Riva, R., Schmeits, S., Jerome, C., Jerome, R. and Lecomte, P., Macromolecules, 2007, 40: 796

    Article  CAS  Google Scholar 

  13. Chang, C., Wei, H., Quan, C.Y., Li, Y.Y., Liu, J., Wang, Z.C., Cheng, S.X., Zhang, X.Z. and Zhuo, R.X., J. Polym. Sci., Part A: Polym. Chem., 2008, 46: 3048

    Article  CAS  Google Scholar 

  14. Zhu, J.L., Zhang, X.Z., Cheng, H., Li, Y.Y., Cheng, S.X. and Zhuo, R.X., J. Polym. Sci., Part A: Polym. Chem., 2007, 45: 5354

    Article  CAS  Google Scholar 

  15. Wei, H., Zhang, X.Z., Chen, W.Q., Cheng, S.X. and Zhuo, R.X., J. Biomed. Mater. Res. A, 2007, 83: 980

    Article  Google Scholar 

  16. Li, Y.Y., Zhang, X.Z., Cheng, H., Zhu, J.L., Cheng, S.X. and Zhuo, R.X., Macromol. Rapid Commun., 2006, 27: 1913

    Article  CAS  Google Scholar 

  17. Fu, H.L., Yu, L., Zhang, H., Zhang, X.Z., Cheng, S.X. and Zhuo, R.X., J. Biomed. Mater. Res. A, 2007, 81A: 186

    Article  CAS  Google Scholar 

  18. Canciello, M., Maglio, G., Nese, G. and Palumbo, R., Macromol. Biosci., 2007, 7: 491

    Article  CAS  Google Scholar 

  19. Taniguchi, I., Kuhlman, W.A., Mayes, A.M. and Griffith, L.G., Polym. Int., 2006, 55: 1385

    Article  CAS  Google Scholar 

  20. Riva, R., Rieger, J., Jerome, R. and Lecomte, P., J. Polym. Sci., Part A: Polym. Chem., 2006, 44: 6015

    Article  CAS  Google Scholar 

  21. Mahmud, A., Xiong, X.B. and Lavasanifar, A., Macromolecules, 2006, 39: 9419

    Article  CAS  Google Scholar 

  22. Yu, G.Q., Zhang, Y., Shi, X.D., Li, Z.S. and Gan, Z.H., J. Biomed. Mater. Res. A, 2008, 84A: 926

    Article  CAS  Google Scholar 

  23. Chu, L.Y., Park, S.H., Yamaguchi, T. and Nakao, S., J. Membr. Sci., 2001, 192: 27

    Article  CAS  Google Scholar 

  24. Wang, H., An, Y.L., Huang, N., Ma, R.J., Li, J.B. and Shi, L.Q., Macromol. Rapid Commun., 2008, 29: 1410

    Article  CAS  Google Scholar 

  25. Choi, C., Chae, S.Y. and Nah, J.W., Polymer, 2006, 47: 4571

    Article  CAS  Google Scholar 

  26. Hales, M., Barner-Kowollik, C., Davis, T.P. and Stenzel, M.H., Langmuir, 2004, 20: 10809

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    Yin Yuan, Pei-jian Sun  (孙培健), Xu-dong Shi, Zhi-hua Gan & Fo-song Wang  (王佛松)

  2. State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials, College of Life Sciences and Technology, Beijing, 100029, China

    Zhi-hua Gan

  3. the Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute, China National Tobacco Corporation, Zhengzhou, 450001, China

    Pei-jian Sun  (孙培健)

Authors
  1. Yin Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pei-jian Sun  (孙培健)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xu-dong Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhi-hua Gan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Fo-song Wang  (王佛松)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Pei-jian Sun  (孙培健) or Fo-song Wang  (王佛松).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 51025314 and 51390481).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yuan, Y., Sun, Pj., Shi, Xd. et al. Biodegradable microspheres with poly(N-isopropylacrylamide) Enriched surface: Thermo-responsibility, biodegradation and drug release. Chin J Polym Sci 33, 1598–1605 (2015). https://doi.org/10.1007/s10118-015-1702-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10118-015-1702-3

Keywords

Search

Navigation