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Microvascular reactivity using laser Doppler measurement in type 2 diabetes with subclinical atherosclerosis

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Abstract

Microangiopathy should be noted in diabetes with subclinical vascular diseases. Little is known about whether various surrogate markers of systemic arterial trees exacerbate simultaneously in preclinical atherosclerosis. To clarify the association of skin microvascular reactivity with arterial stiffness is essential to elucidating early atherosclerotic changes. The post-occlusive reactive hyperemia of skin microcirculation was evaluated in 27 control and 65 type 2 diabetic subjects, including 31 microalbuminuria (MAU) and 34 normoalbuminuria (NAU) patients. The laser Doppler skin perfusion signals were transformed into three frequency intervals for the investigation of endothelial, neurogenic, and myogenic effects on basal and reactive flow motion changes. The analysis of spectral intensity and distribution provided insight into potential significance of microvascular regulation in subclinical atherosclerotic diseases. Systemic arterial stiffness was studied by the brachial ankle pulse wave velocity (baPWV). Following occlusive ischemia, the percent change of endothelial flow motion was lower in MAU than in NAU and control groups. The MAU group revealed a relative increase in myogenic activity and a decrease in endothelial activity in normalized spectra. The baPWV showed more significant associations with reactive endothelial change (r = − 0.48, P < 0.01) and normalized myogenic value (r = − 0.37, P < 0.05) than diabetes duration and HbA1c. By multivariate regression analysis, only endothelial vasomotor changes independently contributed to the decreased baPWV (OR 3.47, 95% CI 1.63–7.42, P < 0.05). Impaired microcirculatory control is associated with increased arterial stiffness in preclinical atherosclerosis. To identify the early manifestations is necessary for at-risk patients to prevent from further vascular damage.

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Abbreviations

MAU:

Diabetes with microalbuminuria

NAU:

Diabetes with normoalbuminuria

baPWV:

Brachial ankle pulse wave velocity

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Author information

Authors and Affiliations

  1. Department of Rehabilitation Medicine, Taipei City Hospital, Taipei, Taiwan

    Pi-Chang Sun

  2. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Pi-Chang Sun

  3. Respiratory Care Ward, Hsiao Chung Cheng Healthcare Group, New Taipei City, Taiwan

    Cheng-Deng Kuo

  4. Tanyu Research Laboratory, Taipei, Taiwan

    Cheng-Deng Kuo

  5. Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan

    Shun-Hwa Wei

  6. Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veteran General Hospital, Taipei, Taiwan

    Hong-Da Lin

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  1. Pi-Chang Sun
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  2. Cheng-Deng Kuo
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  3. Shun-Hwa Wei
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  4. Hong-Da Lin
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Contributions

Study concept and design: Drs Sun, Wei. Recruitment of patients, acquisition of data: Drs Wei, Lin. Analysis and interpretation of data: Drs Sun, Kuo. Draft of the manuscript: Drs Sun, Kuo. Administrative, technical or material support: Drs Kuo, Lin.

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Correspondence to Pi-Chang Sun.

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Sun, PC., Kuo, CD., Wei, SH. et al. Microvascular reactivity using laser Doppler measurement in type 2 diabetes with subclinical atherosclerosis. Lasers Med Sci 38, 80 (2023). https://doi.org/10.1007/s10103-023-03737-x

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