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Efficacy of non-ablative fractional 1440-nm laser therapy for treatment of facial acne scars in patients with rosacea: a prospective, interventional study

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Abstract

Acne scarring is one of the most common facial skin disorders. The appropriate treatments for acne scars in patients with rosacea have not been studied. This study was designed to evaluate the efficacy and safety of non-ablative fractional 1440-nm laser (1440-nm NAFL) therapy for treatment of atrophic acne scars in patients with rosacea. In this prospective, interventional study, 32 patients with rosacea and acne scars underwent three sessions of 1440-nm NAFL therapy. Therapy efficacy, epidermal barrier function, and side effects were evaluated. Thirty patients completed and the median acne scar scores significantly reduced from 45 (30, 50) to 15 (15, 30) after three treatments (P < 0.001). The improvement score of acne scars was 2.7 ± 0.7; 22 (73.3%) were satisfied or highly satisfied. The rosacea erythema scores changed from 2.1 ± 0.4 to 1.9 ± 0.5 (P = 0.326), and flushing, burning, and stinging were not worse. The oil content after treatments was significantly reduced (P < 0.001), while there was no significant difference in other indicators of skin barrier function. The quality-of-life score decreased from 17.5 ± 3.8 to 14.1 ± 3.0 (P < 0.001). No serious side effects were observed. The 1440-nm NAFL therapy is effective in the treatment of acne scaring in patients with rosacea with little damage to the skin barrier.

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Acknowledgments

We acknowledge the medical staff of the Dermatology Department, Xiangya Hospital of Central South University. We would like to thank Editage (www.editage.cn) for English language editing.

Funding

The National Natural Science Foundation of China (81974480, 81573074, 81874246) provided support for the language editing and publication of this article.

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Authors and Affiliations

  1. Department of Dermatology, Xiangya Hospital, Central South University, Xiangya Road, Kaifu District, Changsha, 410008, Hunan, China

    Ben Wang, Yu-xuan Deng, Sha Yan, Hong-fu Xie, Ji Li & Dan Jian

  2. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, China

    Ben Wang, Hong-fu Xie, Ji Li & Dan Jian

Authors
  1. Ben Wang
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  2. Yu-xuan Deng
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  3. Sha Yan
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  4. Hong-fu Xie
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  5. Ji Li
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  6. Dan Jian
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Correspondence to Dan Jian.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee of Xiangya Hospital of Central South University and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Wang, B., Deng, Yx., Yan, S. et al. Efficacy of non-ablative fractional 1440-nm laser therapy for treatment of facial acne scars in patients with rosacea: a prospective, interventional study. Lasers Med Sci 36, 649–655 (2021). https://doi.org/10.1007/s10103-020-03107-x

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