Skip to main content

Advertisement

Log in

Treatment of keloid scars using light-, laser- and energy-based devices: a contemporary review of the literature

  • Review Article
  • Published:
Lasers in Medical Science Aims and scope Submit manuscript

Abstract

Keloid scars are common and have a predilection for young, ethnic skin often with a family history. Keloids can be painful and pruritic and cause significant emotional distress when particularly visible or prominent. In this article, we review the evidence underlying the use of laser- and energy-based devices for treatment of keloid scars, either as monotherapy or in conjunction with other therapies such as corticosteroids, surgery and silicone gel in the treatment of keloid scars.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Ud-Din S, Bayat A (2013) Strategic management of keloid disease in ethnic skin: a structured approach supported by the emerging literature. Br J Dermatol 169:71–81

    Article  PubMed  Google Scholar 

  2. Chike-Obi CJ, Cole PD, Brissett AE (2009) Keloids: pathogenesis, clinical features, and management. Semin Plast Surg 23(3):178–184

    Article  PubMed  PubMed Central  Google Scholar 

  3. Shah VV, Aldahan AS, Mlacker S et al (2016) 5-Fluorouracil in the treatment of keloids and hypertrophic scars: a comprehensive review of the literature. Dermatol Ther 6(2):169–183

    Article  Google Scholar 

  4. Juckett G, Hartman-Adams H (2009) Management of keloids and hypertrophic scars. Am Fam Physician 80(3):253–260

    PubMed  Google Scholar 

  5. Henderson DL, Cromwell TA, Mes LG (1984) Argon and carbon dioxide laser treatment of hypertrophic and keloid scars. Lasers Surg Med 3(4):271–277

    Article  CAS  PubMed  Google Scholar 

  6. Ang C-C, Tay Y-K, Kwok C (2013) Retrospective analysis of earlobe keloids treated with the carbon dioxide laser ablation or cold steel debulking surgery. J Cosmet Laser 15(5):271–273

    Article  Google Scholar 

  7. Martin MS, Collawn SS (2013) Combination treatment of CO2 fractional laser, pulsed dye laser, and triamcinolone acetonide injection for refractory keloid scars on the upper back. J Cosmet Laser Ther 15(3):166–170

    Article  PubMed  Google Scholar 

  8. Nicoletti G, De Francesco F, Mele CM et al (2013) Clinical and histologic effects from CO2 laser treatment of keloids. Lasers Med Sci 28(3):957–964

    Article  PubMed  Google Scholar 

  9. Tenna S, Aveta A, Filoni A et al (2012) A new carbon dioxide laser combined with cyanoacrylate glue to treat earlobe keloids. Plast Reconstr Surg 129(5):843e–844e

    Article  PubMed  Google Scholar 

  10. Scrimali L, Lomeo G, Tamburino S et al (2012) Laser CO2 versus radiotherapy in treatment of keloid scars. J Cosmet Laser Ther 14(2):94–97

    Article  PubMed  Google Scholar 

  11. Garg GA, Sao PP, Khopkar US (2011) Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids. J Cutan Aesthetic Surg 4(1):2–6

    Article  Google Scholar 

  12. Scrimali L, Lomeo G, Nolfo C et al (2010) Treatment of hypertrophic scars and keloids with a fractional CO2 laser: a personal experience. J Cosmet Laser Ther 12(5):218–221

    Article  PubMed  Google Scholar 

  13. Morosolli ARC, De Oliveira Moura Cardoso G et al (2008) Surgical treatment of earlobe keloid with CO2 laser radiation: case report and clinical standpoints. J Cosmet Laser Ther 10(4):226–230

    Article  PubMed  Google Scholar 

  14. Driscoll B (2001) Treating keloids with carbon dioxide lasers. Arch Otolaryngol Head Neck Surg 127(9):1145

    Article  CAS  PubMed  Google Scholar 

  15. Conejo-Mir JS, Corbi R, Linares M (1998) Carbon dioxide laser ablation associated with interferon alfa-2b injections reduces the recurrence of keloids. J Am Acad Dermatol 39(6):1039–1040

    Article  CAS  PubMed  Google Scholar 

  16. Cavalié M, Sillard L, Montaudié H et al (2015) Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther 28(2):74–78

    Article  PubMed  Google Scholar 

  17. Cheng ET, Nowak KC, Koch RJ (2001) Effect of blended carbon dioxide and erbium:YAG laser energy on preauricular and ear lobule keloid fibroblast secretion of growth factors: a serum-free study. Arch Facial Plast Surg 3(4):252–257

    Article  CAS  PubMed  Google Scholar 

  18. Al-Mohamady AE-SAE-H, Ibrahim SMA et al (2016) Pulsed dye laser versus microsecond Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial. J Cosmet Laser 18(4):208–212

  19. Stephanides S, Rai S, August P et al (2011) Treatment of refractory keloids with pulsed dye laser alone and with rotational pulsed dye laser and intralesional corticosteroids: a retrospective case series. Laser Ther 20(4):279–286

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Manuskiatti W, Wanitphakdeedecha R, Fitzpatrick RE (2007) Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. Dermatol Surg 33(2):152–161

    CAS  PubMed  Google Scholar 

  21. Asilian A, Darougheh A, Shariati F (2006) New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg 32(7):907–915

    CAS  PubMed  Google Scholar 

  22. Bellew SG, Weiss MA, Weiss RA (2005) Comparison of intense pulsed light to 595-nm long-pulsed pulsed dye laser for treatment of hypertrophic surgical scars: a pilot study. J Drugs Dermatol JDD 4(4):448–452

    PubMed  Google Scholar 

  23. Manuskiatti W, Fitzpatrick RE (2002) Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments. Arch Dermatol 138(9):1149–1155

    Article  CAS  PubMed  Google Scholar 

  24. Connell PG, Harland CC (2000) Treatment of keloid scars with pulsed dye laser and intralesional steroid. J Cutan Laser Ther 2(3):147–150

    Article  CAS  PubMed  Google Scholar 

  25. Rossi A, Lu R, Frey MK et al (2013) The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids. J Drugs Dermatol JDD 12(11):1256–1262

    PubMed  Google Scholar 

  26. Koike S, Akaishi S, Nagashima Y et al (2014) Nd:YAG laser treatment for keloids and hypertrophic scars: an analysis of 102 cases. Plast Reconstr Surg Glob Open 2(12):e272

    Article  PubMed  Google Scholar 

  27. Abergel RP, Dwyer RM, Meeker CA et al (1984) Laser treatment of keloids: a clinical trial and an in vitro study with Nd:YAG laser. Lasers Surg Med 4(3):291–295

    Article  CAS  PubMed  Google Scholar 

  28. Cho S, Lee J, Lee S et al (2010) Efficacy and safety of 1064-nm Q-switched Nd:YAG laser with low fluence for keloids and hypertrophic scars. J Eur Acad Dermatol Venereol 24(9):1070–1074

    CAS  PubMed  Google Scholar 

  29. Bowes LE, Nouri K, Berman B et al (2002) Treatment of pigmented hypertrophic scars with the 585 nm pulsed dye laser and the 532 nm frequency-doubled Nd:YAG laser in the q-switched and variable pulse modes: a comparative study. Dermatol Surg 28(8):714–719

    PubMed  Google Scholar 

  30. Issa MCA, Kassuga LEBP, Chevrand NS et al (2013) Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment. Int J Dermatol 52(3):367–370

    Article  CAS  PubMed  Google Scholar 

  31. Verhaeghe E, Ongenae K, Bostoen J et al (2013) Nonablative fractional laser resurfacing for the treatment of hypertrophic scars: a randomized controlled trial. Dermatol Surg 39(3 Pt 1):426–434

    Article  CAS  PubMed  Google Scholar 

  32. Lin JY, Warger WC, Izikson L et al (2011) A prospective, randomized controlled trial on the efficacy of fractional photothermolysis on scar remodeling. Lasers Surg Med 43(4):265–272

    Article  PubMed  Google Scholar 

  33. Tierney E, Mahmoud BH, Srivastava D et al (2009) Treatment of surgical scars with nonablative fractional laser versus pulsed dye laser: a randomized controlled trial. Dermatol Surg 35(8):1172–1180

    Article  CAS  PubMed  Google Scholar 

  34. Niwa ABM, Mello APF, Torezan LA et al (2009) Fractional photothermolysis for the treatment of hypertrophic scars: clinical experience of eight cases. Dermatol Surg 35(5):773–778

    Article  CAS  PubMed  Google Scholar 

  35. Capon A, Iarmarcovai G, Gonnelli D et al (2010) Scar prevention using laser-assisted skin healing (LASH) in plastic surgery. Aesthet Plast Surg 34(4):438–446

    Article  Google Scholar 

  36. Cassuto DA, Scrimali L, Siragò P (2010) Treatment of hypertrophic scars and keloids with an LBO laser (532 nm) and silicone gel sheeting. J Cosmet Laser 12(1):32–37

    Article  Google Scholar 

  37. Nouri K, Elsaie ML, Vejjabhinanta V et al (2010) Comparison of the effects of short- and long-pulse durations when using a 585-nm pulsed dye laser in the treatment of new surgical scars. Lasers Med Sci 25(1):121–126

    Article  PubMed  Google Scholar 

  38. Ali FR, Al-Niaimi F (2016) Laser-assisted drug delivery in dermatology: from animal models to clinical practice. Lasers Med Sci 31(2):373–381

    Article  PubMed  Google Scholar 

  39. Waibel JS, Wulkan AJ, Shumaker PR (2013) Treatment of hypertrophic scars using laser and laser assisted corticosteroid delivery. Lasers Surg Med 45(3):135–140

    Article  PubMed  Google Scholar 

  40. Alexis AF (2013) Lasers and light-based therapies in ethnic skin: treatment options and recommendations for Fitzpatrick skin types V and VI. Br J Dermatol 169(Suppl 3):91–97

    Article  PubMed  Google Scholar 

  41. Keaney TC, Tanzi E, Alster T (2016) Comparison of 532 nm potassium titanyl phosphate laser and 595 nm pulsed dye laser in the treatment of erythematous surgical scars: a randomized, controlled, open-label study. Dermatol Surg 42(1):70–76

    Article  CAS  PubMed  Google Scholar 

  42. Yun J-S, Choi Y-J, Kim W-S et al (2011) Prevention of thyroidectomy scars in Asian adults using a 532-nm potassium titanyl phosphate laser. Dermatol Surg 37(12):1747–1753

    Article  CAS  PubMed  Google Scholar 

  43. Park TH, Chang CH (2012) Letter regarding ‘Clinical and histologic effects from CO(2) laser treatment of keloids’. Lasers Med Sci 27(6):1259–1259

    Article  PubMed  Google Scholar 

  44. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature—American Family Physician. http://www.aafp.org/afp/2004/0201/p548.html. Accessed on 26 April 2017

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to F. Al-Niaimi.

Ethics declarations

Conflicts of interest

The authors declare that they have no conflicts of interest.

Additional information

What’s already known about this topic?

• Keloid scars have a higher predilection for younger, ethnic skin.

• Keloid scars can be caused by a multitude of mechanisms, including injury, acne, surgical trauma, piercings and burns.

• Existing treatments for keloid scars include corticosteroid injections, silicone sheeting, cryotherapy, surgical excision, 5-fluorouracil and interferon alfa-2b injections, radiotherapy.

What does this study add?

• We have comprehensively reviewed and summarised contemporary literature relating to the use of light-, laser- and energy-based devices for treatment of keloid scars and quantified the evidence according to the strength of recommendation taxonomy criteria.

• Although initial findings are promising for multiple subcategories of lasers, lights and fractional radiofrequency, current evidence comprises multiple small studies and with few randomised trials

• The use of lasers in keloids is a relatively new concept, as either monotherapy or an adjunct to medical therapies. Future use of laser-assisted delivery to treat keloid scars has potential.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Forbat, E., Ali, F.R. & Al-Niaimi, F. Treatment of keloid scars using light-, laser- and energy-based devices: a contemporary review of the literature. Lasers Med Sci 32, 2145–2154 (2017). https://doi.org/10.1007/s10103-017-2332-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10103-017-2332-5

Keywords

Navigation