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The effect of laser power, blood perfusion, thermal and optical properties of human liver tissue on thermal damage in LITT

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Abstract

In this work, the finite-element method (FEM) was used to predict the temperature distribution, and the thermal damage volume in human liver tissue subjected to laser in laser-induced interstitial thermotherapy (LITT). The effect of laser power, blood perfusion, and thermal and optical properties on maximum temperature and thermal damage volume were predicted using the finite-element method. A computer program was written in visual basic language, which was verified by comparing its result with data published elsewhere. The bio-heat equation together with the effect of linear laser source were used to simulate heat transfer through tissue from which the temperature distributions, and the subsequent thermal damage, were obtained based on Arrhenius equation. In this mathematical model for LITT, it was found that increasing laser power, absorption, and scattering coefficient increased the damage zone while increasing tissue water content, perfusion rate, and tissue anisotropy factor decreased the damage zone. These findings are important aspects for doctors in the pre-estimation of the damage zone before starting the therapy so as to kill only the desired zone.

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Authors and Affiliations

  1. Laser and Optoelectronic Engineering Department, University of Technology, Baghdad, Iraq

    Khalid Salem Shibib, Mohammed A. Munshid & Hind Ali Lateef

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  1. Khalid Salem Shibib
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  2. Mohammed A. Munshid
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  3. Hind Ali Lateef
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Correspondence to Khalid Salem Shibib.

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Since it is a theoretical work done by the authors, then there is no healthcare intervention on a person.

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Shibib, K.S., Munshid, M.A. & Lateef, H.A. The effect of laser power, blood perfusion, thermal and optical properties of human liver tissue on thermal damage in LITT. Lasers Med Sci 32, 2039–2046 (2017). https://doi.org/10.1007/s10103-017-2321-8

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  • DOI: https://doi.org/10.1007/s10103-017-2321-8

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