Skip to main content

Advertisement

SpringerLink
Log in

Predictive factors for focal disease in human brucellosis, an observational cohort study

  • Brief Report
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

This retrospective cohort study aimed to identify predictors for focal disease in human brucellosis. The study included patients with brucellosis diagnosed between January 2000 and December 2021. Overall, 247 patients were identified. Focal disease was diagnosed in 64 (25.9%) patients. The most common focal infection was bone and joint in 56 patients (23.4%). Disease duration > 14 days was significantly associated with focal illness [OR = 2.2 (1.08–4.47), p = 0.030], although febrile illness was inversely associated with focal illness this did not reach statistical significance [OR = 0.46 (0.21–1.00), p = 0.050]. Focal brucellosis should be suspected in patients with prolonged illness.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Data availability

Data are available in the hospital's electronic medical records.

References

  1. Franco MP, Mulder M, Gilman RH, Smits HL (2007) Human brucellosis. Lancet Infect Dis 7:775–86. (https://pubmed.ncbi.nlm.nih.gov/18045560/10.1016/S1473-3099(07)70286-4)

    Article  CAS  Google Scholar 

  2. Bosilkovski M, Krteva L, Dimzova M, Vidinic I, Sopova Z, Spasovska K (2010) Human brucellosis in Macedonia-10 years of clinical experience in endemic region. Croat Med J 51:327–36. (https://pubmed.ncbi.nlm.nih.gov/20718086/10.3325/cmj.2010.51.327)

    Article  Google Scholar 

  3. Bosilkovski M, Krteva L, Dimzova M, Kondova I (2007) Brucellosis in 418 patients from the Balkan Peninsula: exposure-related differences in clinical manifestations, laboratory test results, and therapy outcome. Int J Infect Dis 11:342–7. (https://pubmed.ncbi.nlm.nih.gov/17241808/10.1016/J.IJID.2006.10.002)

    Article  CAS  Google Scholar 

  4. Guler S, Kokoglu OF, Ucmak H, Gul M, Ozden S, Ozkan F (2014) Human brucellosis in Turkey: different clinical presentations. J Infect Dev Ctries 8:581–8. (https://pubmed.ncbi.nlm.nih.gov/24820461/10.3855/jidc.3510)

    Article  Google Scholar 

  5. Copur B, Sayili U (2022) Laboratory and clinical predictors of focal involvement and bacteremia in brucellosis. Eur J Clin Microbiol Infect Dis 41:793–801. (https://pubmed.ncbi.nlm.nih.gov/35364783/10.1007/S10096-022-04436-1)

    Article  CAS  Google Scholar 

  6. Kayaaslan B, Bastug A, Aydin E, Akinci E, But A, Aslaner H et al (2016) A long-term survey of brucellosis: is there any marker to predict the complicated cases? Infect Dis (London England) 48:215–21. (https://pubmed.ncbi.nlm.nih.gov/26568367/10.3109/23744235.2015.1107187)

    Google Scholar 

  7. Demirdal T, Sen P (2020) Risk factors for focal involvement in brucellosis. Diagn Microbiol Infect Dis 1:97. (https://pubmed.ncbi.nlm.nih.gov/32037038/10.1016/J.DIAGMICROBIO.2020.115003)

    Google Scholar 

  8. Xu N, Dong X, Yao Y, Guan Y, Chen F, Zheng F et al (2020) Improved early detection of focal brucellosis complications with anti- brucella IgG. J Clin Microbiol 1:58. (https://pubmed.ncbi.nlm.nih.gov/32817225/10.1128/JCM.00903-20)

    Google Scholar 

  9. Colmenero JD, Reguera JM, Martos F, Sánchez-De-Mora D, Delgado M, Causse M et al (1996) Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75:195–211. (https://pubmed.ncbi.nlm.nih.gov/8699960/10.1097/00005792-199607000-00003)

    Article  CAS  Google Scholar 

  10. Brucellosis - Chapter 4 - 2020 yellow book | Travelers’ Health | CDC. https://wwwnc.cdc.gov/travel/yellowbook/2020/travel-related-infectious-diseases/brucellosis

  11. Liu CM, Suo B, Zhang Y (2021) Analysis of clinical manifestations of acute and chronic brucellosis in patients admitted to a public general hospital in Northern China. Int J Gen Med 14:8311–6. (https://pubmed.ncbi.nlm.nih.gov/34815703/10.2147/IJGM.S336850)

    Article  Google Scholar 

  12. Skalsky K, Yahav D, Bishara J, Pitlik S, Leibovici L, Paul M (2008) Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials. BMJ 29(336):701–704. https://doi.org/10.1136/bmj.39497.500903.25

    Article  CAS  Google Scholar 

  13. for Disease Control C. Brucellosis reference guide: exposures, testing, and prevention. http://www.selectagents.gov/

  14. Romero C, Gamazo C, Pardo M, Lopez-Goni I (1995) Specific detection of Brucella DNA by PCR. J Clin Microbiol 33:615–7. (https://pubmed.ncbi.nlm.nih.gov/7538508/10.1128/JCM.33.3.615-617.1995)

    Article  CAS  Google Scholar 

  15. HasanjaniRoushan MR, Mohrez M, SmailnejadGangi SM, SoleimaniAmiri MJ, Hajiahmadi M (2004) Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect 132:1109–14. (https://pubmed.ncbi.nlm.nih.gov/15635968/10.1017/S0950268804002833)

    Article  CAS  Google Scholar 

  16. Bosilkovski M, Siskova D, Spasovska K, Vidinic I, Dimzova M (2019) The influence of illness duration before diagnosis on clinical characteristics and outcome in human brucellosis. Trop Doct 49:177–81. (https://pubmed.ncbi.nlm.nih.gov/31060447/10.1177/0049475519846422)

    Article  Google Scholar 

  17. Shevtsova E, Vergnaud G, Shevtsov A, Shustov A, Berdimuratova K, Mukanov K et al (2019) Genetic diversity of brucella melitensis in kazakhstan in relation to world-wide diversity. Front Microbiol 10:1897. https://doi.org/10.3389/FMICB.2019.01897/BIBTEX

    Article  Google Scholar 

  18. Zhu Y, Shi L, Zeng Y, Piao D, Xie Y, Du J et al (2022) Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China. Infect Dis Poverty 11:63. (http://www.ncbi.nlm.nih.gov/pubmed/3565908710.1186/s40249-022-00989-7)

    Article  Google Scholar 

  19. Ghanem-Zoubi N, Eljay SP, Anis E, Paul M (2018) Association between human brucellosis and adverse pregnancy outcome: a cross-sectional population-based study. Eur J Clin Microbiol Infect Dis 37:883–8. (https://pubmed.ncbi.nlm.nih.gov/29344838/10.1007/s10096-017-3181-7)

    Article  Google Scholar 

  20. Ghanem-Zoubi N, Eljay SP, Anis E, Paul M (2019) Reemergence of human brucellosis in Israel. Isr Med Assoc J 21:10–2. https://pubmed.ncbi.nlm.nih.gov/30685898/

Download references

Author information

Author notes

  1. Imad Kassis and Nesrin Ghanem-Zoubi contributed equally to the study and article.

Authors and Affiliations

  1. Pediatric Infectious Diseases Unit, Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel

    Halima Dabaja-Younis, Elias Nasrallah & Imad Kassis

  2. The Ruth and Bruce Rappaport Faculty of Medicine, Israel Institute of Technology, Technion, Haifa, Israel

    Halima Dabaja-Younis, Menas Atarieh, Michal Paul, Imad Kassis & Nesrin Ghanem-Zoubi

  3. Infectious Diseases Unit, Rambam Health Care Campus, Haifa, Israel

    Michal Paul & Nesrin Ghanem-Zoubi

  4. Microbiology Laboratory, Rambam Health Care Campus, Haifa, Israel

    Yuval Geffen

Authors
  1. Halima Dabaja-Younis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Menas Atarieh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michal Paul
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Elias Nasrallah
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yuval Geffen
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Imad Kassis
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Nesrin Ghanem-Zoubi
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed equally to this study. Dr. M. Atarieh and Dr. E. Nasrallah helped in collecting medical data from electronic medical records. Prof. M. Paul helped in processing the data and reviewing the manuscript, and Dr. Y. Geffen assisted in extracting blood culture and serology data from the laboratory system. Dr. Nesrin Ghanem—Zoubi and Prof. I. Kassis had guided and supervised the study, helped in processing the data and editing the manuscript, and finally, I, Dr. H. Dabaja-Younis, compiled the medical and microbiological data, processed the data, and wrote the manuscript.

Corresponding author

Correspondence to Halima Dabaja-Younis.

Ethics declarations

Ethics approval

The study was approved by the local hospital ethics committee.

Consent to participate

No informed consent was required from participants.

Consent for publication

All authors consented to publication of the manuscript.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dabaja-Younis, H., Atarieh, M., Paul, M. et al. Predictive factors for focal disease in human brucellosis, an observational cohort study. Eur J Clin Microbiol Infect Dis 42, 221–226 (2023). https://doi.org/10.1007/s10096-022-04541-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-022-04541-1

Keywords

Search

Navigation