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Current taxonomy of Rhodococcus species and their role in infections

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Abstract

Rhodococcus is a genus of obligate aerobic, Gram-positive, partially acid-fast, catalase-positive, non-motile, and none-endospore bacteria. The genus Rhodococcus was first introduced by Zopf. This bacterium can be isolated from various sources of the environment and can grow well in non-selective medium. A large number of phenotypic characterizations are used to compare different species of the genus Rhodococcus, and these tests are not suitable for accurate identification at the genus and species level. Among nucleic acid-based methods, the most powerful target gene for revealing reliable phylogenetic relationships is 16S ribosomal RNA gene (16S rRNA gene) sequence analysis, but this gene is unable to differentiation some of Rhodococcus species. To date, whole genome sequencing analysis has solved taxonomic complexities in this genus. Rhodococcus equi is the major cause of foal pneumonia, and its implication in human health is related to cases in immunocompromised patients. Macrolide family together with rifampicin is one of the most effective antibiotic agents for treatment rhodococcal infections.

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References

  1. Goodfellow M, Alderson G (1977) The actinomycete-genus Rhodococcus: a home for the ‘rhodochrous’ complex. Microbiology 100(1):99–122

    CAS  Google Scholar 

  2. Yanagawa R, Honda E (1976) Presence of pili in species of human and animal parasites and pathogens of the genus corynebacterium. Infect Immun 13(4):1293–1295

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Finnerty WR (1992) The biology and genetics of the genus Rhodococcus. Annu Rev Microbiol 46(1):193–218

    Article  CAS  PubMed  Google Scholar 

  4. Klatte S, Kroppenstedt RM, Rainey FA (1994) Rhodococcus opacus sp. nov., an unusual nutritionally versatile Rhodococcus-species. Syst Appl Microbiol 17(3):355–360

    Article  Google Scholar 

  5. Zopf W (1891) Über Ausscheidung von Fettfarbstoffen Lipochromen seitens gewisser Spaltpilze. https://doi.org/10.1111/j.1438-8677.1891.tb05764.x

  6. Goodfellow M, Alderson G, Chun J (1998) Rhodococcal systematics: problems and developments. Antonie Van Leeuwenhoek 74(1–3):3–20

    Article  CAS  PubMed  Google Scholar 

  7. Li Y, Kawamura Y, Fujiwara N, Naka T, Liu H, Huang X et al (2004) Rothia aeria sp. nov., Rhodococcus baikonurensis sp. nov. and Arthrobacter russicus sp. nov., isolated from air in the Russian space laboratory Mir. Int J Syst Evol Microbiol 54(3):827–835

    Article  CAS  PubMed  Google Scholar 

  8. Su X, Liu Y, Hashmi MZ, Hu J, Ding L, Wu M et al (2015) Rhodococcus biphenylivorans sp. nov., a polychlorinated biphenyl-degrading bacterium. Antonie Van Leeuwenhoek 107(1):55–63

    Article  CAS  PubMed  Google Scholar 

  9. Rowbotham T, Cross T (1977) Rhodococcus coprophilus sp. nov.: an aerobic nocardioform actinomycete belonging to the ‘rhodochrous’ complex. Microbiology 100(1):123–138

    Google Scholar 

  10. Švec P, Černohlávková J, Busse H-J, Vojtková H, Pantu R, Cnockaert M et al (2015) Classification of strain CCM 4446T as Rhodococcus degradans sp. nov. Int J Syst Evol Microbiol 65(12):4381–4387

    Article  CAS  PubMed  Google Scholar 

  11. Goodfellow M, Weaver C, Minnikin D (1982) Numerical classification of some rhodococci, corynebacteria and related organisms. Microbiology 128(4):731–745

    Article  CAS  Google Scholar 

  12. Wang Y-X, Wang H-B, Zhang Y-Q, Xu L-H, Jiang C-L, Li W-J (2008) Rhodococcus kunmingensis sp. nov., an actinobacterium isolated from a rhizosphere soil. Int J Syst Evol Microbiol 58(6):1467–1471

    Article  CAS  PubMed  Google Scholar 

  13. Li B, Furihata K, Ding L-X, Yokota A (2007) Rhodococcus kyotonensis sp. nov., a novel actinomycete isolated from soil. Int J Syst Evol Microbiol 57(9):1956–1959

    Article  CAS  PubMed  Google Scholar 

  14. Helmke E, Weyland H (1984) Rhodococcus marinonascens sp. nov., an actinomycete from the sea. Int J Syst Evol Microbiol 34(2):127–138

    Google Scholar 

  15. Li J, Zhao G-Z, Long L-J, Wang F-Z, Tian X-P, Zhang S et al (2012) Rhodococcus nanhaiensis sp. nov., an actinobacterium isolated from marine sediment. Int J Syst Evol Microbiol 62(10):2517–2521

    Article  CAS  PubMed  Google Scholar 

  16. Táncsics A, Benedek T, Farkas M, Máthé I, Márialigeti K, Szoboszlay S et al (2014) Sequence analysis of 16S rRNA, gyrB and catA genes and DNA–DNA hybridization reveal that Rhodococcus jialingiae is a later synonym of Rhodococcus qingshengii. Int J Syst Evol Microbiol 64(1):298–301

    Article  PubMed  Google Scholar 

  17. Xu J-L, He J, Wang Z-C, Wang K, Li W-J, Tang S-K et al (2007) Rhodococcus qingshengii sp. nov., a carbendazim-degrading bacterium. Int J Syst Evol Microbiol 57(12):2754–2757

    Article  CAS  PubMed  Google Scholar 

  18. Goodfellow M (2015) Actinobacteria. In Bergey's manual of systematics of archaea and Bacteria (eds W. B. Whitman, F. Rainey, P. Kämpfer, M. Trujillo, J. Chun, P. DeVos, B. Hedlund and S. Dedysh)

  19. Tsukamura M (1974) A further numerical taxonomic study of the rhodochrous group. Microbiol Immunol 18(1):37–44

    CAS  Google Scholar 

  20. Jones AL, Goodfellow M (2012) Genus IV. Rhodococcus (Zopf 1891) emend. Goodfellow, Alderson and Chun 1998a. In Bergey’s manual of systematic bacteriology, 2nd edn, vol. 5, the Actino- bacteria, part a, pp. 437–464. Edited by M. Goodfellow, P. Kämpfer, H.-J. Busse, M. E. Trujillo, K. Suzuki, W. Ludwig, W. B. Whitman. New York: Springer

  21. Lechevalier MP, Lechevalier H (1970) Chemical composition as a criterion in the classification of aerobic actinomycetes. Int J Syst Evol Microbiol 20(4):435–443

    CAS  Google Scholar 

  22. Goodfellow, M. (1992) The family nocardiaceae. In The prokaryotes ed. Balows, A., Trüper, H.G., Dworkin, M., Harder, W. and Schleifer, K.H. pp. 1188–1213. Berlin: Springer-Verlag

    Google Scholar 

  23. Stackebrandt E, Smida J, Collins MD (1988) Evidence of phylogenetic heterogeneity within the genus Rhodococcus: revival of the genus Gordona (Tsukamura). J Gen Appl Microbiol 34(4):341–348

    Article  Google Scholar 

  24. Rainey F, Klatte S, Kroppenstedt R, Stackebrandt E (1995) Dietzia, new genus including Dietzia maris comb. nov., formerly Rhodococcus maris. Int J Syst Evol Microbiol 45(1):32–36

    CAS  Google Scholar 

  25. Bell K, Philp J, Aw D, Christofi N (1998) The genus Rhodococcus. J Appl Microbiol 85(2):195–210

    Article  CAS  PubMed  Google Scholar 

  26. De'Clari F, Menghini T, Biaggi G, Magnoli P (1992) Septicaemia due to a new species of Rhodococcus that contaminated closed system packed red blood cells-cure with imipenem monotherapy. J Antimicrob Chemother 30(5):729–730

    Article  CAS  PubMed  Google Scholar 

  27. Ivshina I, Kamenskikh T, Liapunov Y (1994) IEGM catalogue of strains of regional specialized collection of alkanotrophic microorganisms. Nauka, Moscow

    Google Scholar 

  28. Tikhonova E, Ermakova I, Golovlev E (1996) Response of Rhodococcus minimus cultures to changes in the concentration of the carbon source: macromolecular composition and energy metabolism. Microbiology 65(4):395–399

    Google Scholar 

  29. Liu D. Molecular detection of human bacterial pathogens: CRC press; 2011

    Book  Google Scholar 

  30. Silva P, Santos ACB, Sato DN, Silva JO, Medeiros MIC, Carneiro AMM et al (2012) Phenotypic and genotypic characterization of Rhodococcus equi isolated from sputum. Braz J Infect Dis 16(5):409–415

    Article  CAS  PubMed  Google Scholar 

  31. Connie R, Mahon L, Donald C (2018) Textbook of diagnostic microbiology. Elsevier ISBN: 0323613179

  32. Brown J, McNeil M, Desmond E (1999) Nocardia, Rhodococcus, Gordona, Actinomadura, Streptomyces, and other actinomycetes of medical importance. Manual of clinical microbiology, 7th ed. American Society for Microbiology, Washington, DC, pp 370–398

    Google Scholar 

  33. Prescott JF, Hoffman AM (1993) Rhodococcus equi. Vet Clin North Am Equine Pract 9(2):375–384

    Article  CAS  PubMed  Google Scholar 

  34. Makrai L, Fodor L, Vendég I, Szigeti G, Dénes B, Reiczigel J et al (2005) Comparison of selective media for the isolation of Rhodococcus equi and description of a new selective plating medium. Acta Vet Hung 53(3):275–285

    Article  CAS  PubMed  Google Scholar 

  35. Barton MD, Hughes KL (1981) Comparison of three techniques for isolation of Rhodococcus (Corynebacterium) equi from contaminated sources. J Clin Microbiol 13(1):219–221

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Woolcock JB, Farmer A, Mutimer MD (1979) Selective medium for Corynebacterium equi isolation. J Clin Microbiol 9(5):640–642

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Rowbotham T, Cross T (1977) Ecology of Rhodococcus coprophilus and associated actinomycetes in fresh water and agricultural habitats. Microbiology 100(2):231–240

    Google Scholar 

  38. Glickman SE, Kilburn JO, Butler WR, Ramos LS (1994) Rapid identification of mycolic acid patterns of mycobacteria by high-performance liquid chromatography using pattern recognition software and a Mycobacterium library. J Clin Microbiol 32(3):740–745

    CAS  PubMed  PubMed Central  Google Scholar 

  39. Miyaji MYK, Moretti-Branchini ML et al (2002) Actinomicetos. In: Fungos patogênicos—guia prático de laboratório. v. 1, Campinas

  40. Amat GC (2004) Detección y caracterización por métodos fenotípicos y moleculares de mycolata formadores de espumas en estaciones depuradoras de aguas residuales domésticas con sistemas de fangos activos. Universitat Politècnica de València

  41. Reddy CA, Kao M (1978) Value of acid metabolic products in identification of certain corynebacteria. J Clin Microbiol 7(5):428–433

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Butler W, Kilburn JO, Kubica GP (1987) High-performance liquid chromatography analysis of mycolic acids as an aid in laboratory identification of Rhodococcus and Nocardia species. J Clin Microbiol 25(11):2126–2131

    CAS  PubMed  PubMed Central  Google Scholar 

  43. de Alegría Puig CR, Pilares L, Marco F, Vila J, Martínez-Martínez L, Navas J (2017) Comparison of the Vitek MS and Bruker matrix-assisted laser desorption ionization–time of flight mass spectrometry Systems for Identification of Rhodococcus equi and Dietzia spp. J Clin Microbiol 55(7):2255–2260

    Article  PubMed  PubMed Central  Google Scholar 

  44. Badieyan S, Dilmaghani-Marand A, Hajipour MJ, Ameri A, Razzaghi MR, Rafii-Tabar H et al (2018) Detection and discrimination of bacterial colonies with Mueller matrix imaging. Sci Rep 8(1):10815

    Article  PubMed  PubMed Central  Google Scholar 

  45. Hwang CY, Lee I, Cho Y, Lee YM, Baek K, Jung Y-J et al (2015) Rhodococcus aerolatus sp. nov., isolated from subarctic rainwater. Int J Syst Evol Microbiol 65(2):465–471

    Article  CAS  PubMed  Google Scholar 

  46. Goodfellow M, Jones AL, Maldonado LA, Salanitro J (2004) Rhodococcus aetherivorans sp. nov., a new species that contains methyl t-butyl ether-degrading actinomycetes. Syst Appl Microbiol 27(1):61–65

    Article  CAS  PubMed  Google Scholar 

  47. Guo Q-Q, Ming H, Meng X-L, Duan Y-Y, Gao R, Zhang J-X et al (2015) Rhodococcus agglutinans sp. nov., an actinobacterium isolated from a soil sample. Antonie Van Leeuwenhoek 107(5):1271–1280

    Article  CAS  PubMed  Google Scholar 

  48. Ko KS, Kim Y, Seong CN, Lee SD (2015) Rhodococcus antrifimi sp. nov., isolated from dried bat dung of a cave. Int J Syst Evol Microbiol 65(11):4043–4048

    Article  CAS  PubMed  Google Scholar 

  49. Zhao G-Z, Li J, Zhu W-Y, Tian S-Z, Zhao L-X, Yang L-L et al (2012) Rhodococcus artemisiae sp. nov., an endophytic actinobacterium isolated from the pharmaceutical plant Artemisia annua L. Int J Syst Evol Microbiol 62(4):900–905

    Article  CAS  PubMed  Google Scholar 

  50. Ferreira N, Tracey R (1984) Numerical taxonomy of cholesterol-degrading soil bacteria. J Appl Microbiol 57(3):429–446

    CAS  Google Scholar 

  51. Nimaichand S, Sanasam S, Zheng L-Q, Zhu W-Y, Yang L-L, Tang S-K et al (2013) Rhodococcus canchipurensis sp. nov., an actinomycete isolated from a limestone deposit site. Int J Syst Evol Microbiol 63(1):114–118

    Article  PubMed  Google Scholar 

  52. Kämpfer P, Wellner S, Lohse K, Lodders N, Martin K (2013) Rhodococcus cerastii sp. nov. and Rhodococcus trifolii sp. nov., two novel species isolated from leaf surfaces. Int J Syst Evol Microbiol 63(3):1024–1029

    Article  CAS  PubMed  Google Scholar 

  53. Li J, Zhao G-Z, Chen H-H, Qin S, Xu L-H, Jiang C-L et al (2008) Rhodococcus cercidiphylli sp. nov., a new endophytic actinobacterium isolated from a Cercidiphyllum japonicum leaf. Syst Appl Microbiol 31(2):108–113

    Article  CAS  PubMed  Google Scholar 

  54. Yassin A, Schaal K (2005) Reclassification of Nocardia corynebacterioides Serrano et al. 1972 (approved lists 1980) as Rhodococcus corynebacterioides comb. nov. Int J Syst Evol Microbiol 55(3):1345–1348

    Article  CAS  PubMed  Google Scholar 

  55. Kämpfer P, Dott W, Martin K, Glaeser SP (2014) Rhodococcus defluvii sp. nov., isolated from wastewater of a bioreactor and formal proposal to reclassify [Corynebacterium hoagii] and Rhodococcus equi as Rhodococcus hoagii comb. nov. Int J Syst Evol Microbiol 64(3):755–761

    Article  CAS  PubMed  Google Scholar 

  56. Ramaprasad E, Mahidhara G, Sasikala C, Ramana CV (2018) Rhodococcus electrodiphilus sp. nov., a marine electro active actinobacterium isolated from coral reef. Int J Syst Evol Microbiol 68(8):2644–2649

    Article  CAS  PubMed  Google Scholar 

  57. Dastager SG, Mawlankar R, Tang S-K, Krishnamurthi S, Ramana VV, Joseph N et al (2014) Rhodococcus enclensis sp. nov., a novel member of the genus Rhodococcus. Int J Syst Evol Microbiol 64(8):2693–2697

    Article  CAS  PubMed  Google Scholar 

  58. Goodfellow M (1984) Reclassification of Corynebacterium fascians (Tilford) Dowson in the genus Rhodococcus, as Rhodococcus fascians comb. nov. Syst Appl Microbiol 5(2):225–229

    Article  Google Scholar 

  59. Ma J, Zhang L, Wang G, Zhang S, Zhang X, Wang Y et al (2017) Rhodococcus gannanensis sp. nov., a novel endophytic actinobacterium isolated from root of sunflower (Helianthus annuus L.). Antonie Van Leeuwenhoek 110(9):1113–1120

    Article  CAS  PubMed  Google Scholar 

  60. Jones AL, Brown JM, Mishra V, Perry JD, Steigerwalt AG, Goodfellow M (2004) Rhodococcus gordoniae sp. nov., an actinomycete isolated from clinical material and phenol-contaminated soil. Int J Syst Evol Microbiol 54(2):407–411

    Article  CAS  PubMed  Google Scholar 

  61. Nguyen TM, Kim J (2016) Rhodococcus pedocola sp. nov. and Rhodococcus humicola sp. nov., two antibiotic-producing actinomycetes isolated from soil. Int J Syst Evol Microbiol 66(6):2362–2369

    Article  CAS  PubMed  Google Scholar 

  62. Ghosh A, Paul D, Prakash D, Mayilraj S, Jain RK (2006) Rhodococcus imtechensis sp. nov., a nitrophenol-degrading actinomycete. Int J Syst Evol Microbiol 56(8):1965–1969

    Article  CAS  PubMed  Google Scholar 

  63. Takeuchi M, Hatano K, Sedlácek I, Pácová Z (2002) Rhodococcus jostii sp. nov., isolated from a medieval grave. Int J Syst Evol Microbiol 52(2):409–413

    Article  CAS  PubMed  Google Scholar 

  64. Yoon J-H, Cho Y-G, Kang S-S, Kim SB, Lee ST, Park Y-H (2000) Rhodococcus koreensis sp. nov., a 2, 4-dinitrophenol-degrading bacterium. Int J Syst Evol Microbiol 50(3):1193–1201

    Article  CAS  PubMed  Google Scholar 

  65. Liu H, Zhang Y, Liu C, Fang B, Li C, Guan X et al (2014) Rhodococcus kronopolitis sp. nov., a novel actinobacterium isolated from a millipede (Kronopolites svenhedind Verhoeff). Antonie Van Leeuwenhoek 106(6):1207–1214

    Article  CAS  PubMed  Google Scholar 

  66. Mayilraj S, Krishnamurthi S, Saha P, Saini HS (2006) Rhodococcus kroppenstedtii sp. nov., a novel actinobacterium isolated from a cold desert of the Himalayas, India. Int J Syst Evol Microbiol 56(5):979–982

    Article  CAS  PubMed  Google Scholar 

  67. Singh PK, Kumari A, Chawla N, Pinnaka AK, Korpole S (2015) Rhodococcus lactis sp. nov., an actinobacterium isolated from sludge of a dairy waste treatment plant. Int J Syst Evol Microbiol 65(11):4215–4220

    Article  CAS  PubMed  Google Scholar 

  68. Zhang J, Zhang Y, Xiao C, Liu Z, Goodfellow M (2002) Rhodococcus maanshanensis sp. nov., a novel actinomycete from soil. Int J Syst Evol Microbiol 52(6):2121–2126

    CAS  PubMed  Google Scholar 

  69. Briglia M, Rainey F, Stackebrandt E, Schraa G, Salkinoja-Salonen M (1996) Rhodococcus percolatus sp. nov., a bacterium degrading 2, 4, 6-trichlorophenol. Int J Syst Evol Microbiol 46(1):23–30

    CAS  Google Scholar 

  70. Rehfuss M, Urban J (2005) Rhodococcus phenolicus sp. nov., a novel bioprocessor isolated actinomycete with the ability to degrade chlorobenzene, dichlorobenzene and phenol as sole carbon sources. Syst Appl Microbiol 28(8):695–701

    Article  CAS  PubMed  Google Scholar 

  71. Silva LJ, Souza DT, Genuario DB, Hoyos HAV, Santos SN, Rosa LH et al (2018) Rhodococcus psychrotolerans sp. nov., isolated from rhizosphere of Deschampsia antarctica. Antonie Van Leeuwenhoek 111(4):629–636

    Article  CAS  PubMed  Google Scholar 

  72. Yoon J-H, Kang S-S, Cho Y-G, Lee ST, Kho YH, Kim C-J et al (2000) Rhodococcus pyridinivorans sp. nov., a pyridine-degrading bacterium. Int J Syst Evol Microbiol 50(6):2173–2180

    Article  CAS  PubMed  Google Scholar 

  73. Li S-H, Yu X-Y, Park D-J, Hozzein WN, Kim C-J, Shu W-S et al (2015) Rhodococcus soli sp. nov., an actinobacterium isolated from soil using a resuscitative technique. Antonie Van Leeuwenhoek 107(2):357–366

    Article  CAS  PubMed  Google Scholar 

  74. Táncsics A, Máthé I, Benedek T, Tóth EM, Atasayar E, Spröer C et al (2017) Rhodococcus sovatensis sp. nov., an actinomycete isolated from the hypersaline and heliothermal Lake Ursu. Int J Syst Evol Microbiol 67(2):190–196

    Article  PubMed  Google Scholar 

  75. Yassin A (2005) Rhodococcus triatomae sp. nov., isolated from a blood-sucking bug. Int J Syst Evol Microbiol 55(4):1575–1579

    Article  CAS  PubMed  Google Scholar 

  76. Matsuyama H, Yumoto I, Kudo T, Shida O (2003) Rhodococcus tukisamuensis sp. nov, isolated from soil. Int J Syst Evol Microbiol 53(5):1333–1337

    Article  CAS  PubMed  Google Scholar 

  77. Goodfellow M, Chun J, Stackebrandt E, Kroppenstedt RM (2002) Transfer of Tsukamurella wratislaviensis Goodfellow et a. 1995 to the genus Rhodococcus as Rhodococcus wratislaviensis comb. nov. Int J Syst Evol Microbiol 52(3):749–755

    CAS  PubMed  Google Scholar 

  78. Zhang Y-Q, Li W-J, Kroppenstedt RM, Kim C-J, Chen G-Z, Park D-J et al (2005) Rhodococcus yunnanensis sp. nov., a mesophilic actinobacterium isolated from forest soil. Int J Syst Evol Microbiol 55(3):1133–1137

    Article  CAS  PubMed  Google Scholar 

  79. Stoecker MA, Herwig RP, Staley JT (1994) Rhodococcus zopfii sp. nov., a toxicant-degrading bacterium. Int J Syst Evol Microbiol 44(1):106–110

    CAS  Google Scholar 

  80. Fatahi-Bafghi M (2015) Rhodococcus equi: are phenotypic tests the best method for accurate identification? Comp Clin Path 24(5):979–979

    Article  Google Scholar 

  81. Mutimer M, Woolcock J (1983) A note on hydrolytic enzymes of Corynebacterium equi. J Appl Microbiol 55(2):367–369

    CAS  Google Scholar 

  82. Venner M, Heyers P, Strutzberg-Minder K, Lorenz N, Verspohl J, Klug E (2007) Detection of Rhodococcus equi by microbiological culture and by polymerase chain reaction in samples of tracheobronchial secretions of foals. Berliner und Munchener Tierarztliche Wochenschrift 120(3–4):126–133

    CAS  PubMed  Google Scholar 

  83. Deurenberg RH, Bathoorn E, Chlebowicz MA, Couto N, Ferdous M, García-Cobos S et al (2017) Application of next generation sequencing in clinical microbiology and infection prevention. J Biotechnol 243:16–24

    Article  CAS  PubMed  Google Scholar 

  84. Buchan BW, Ledeboer NA (2014) Emerging technologies for the clinical microbiology laboratory. Clin Microbiol Rev 27(4):783–822

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Park G, Jin WY, Jang SJ, Kook JK, Choi J, Park GC et al (2015) Evaluation of four methods of assigning species and genus to medically important bacteria using 16S rRNA gene sequence analysis. Microbiol Immunol 59(5):285–298

    Article  CAS  PubMed  Google Scholar 

  86. Sangal V, Nieminen L, Tucker NP, Hoskisson PA (2014) Revolutionizing prokaryotic systematics through next-generation sequencing. Methods Microbiol 41:75–101

    Article  CAS  Google Scholar 

  87. Sellon D, Walker K, Suyemoto M, Altier C (1997) Nucleic acid amplification for rapid detection of Rhodococcus equi in equine blood and tracheal wash fluids. Am J Vet Res 58(11):1232–1237

    CAS  PubMed  Google Scholar 

  88. Takai S, Ikeda T, Sasaki Y, Watanabe Y, Ozawa T, Tsubaki S et al (1995) Identification of virulent Rhodococcus equi by amplification of gene coding for 15-to 17-kilodalton antigens. J Clin Microbiol 33(6):1624–1627

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Bryan LK, Alexander ER, Lawhon SD, Cohen ND (2018) Detection of vapN in Rhodococcus equi isolates cultured from humans. PLoS One 13(1):e0190829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Navas J, González-Zorn B, Ladrón N, Garrido P, Vázquez-Boland JA (2001) Identification and mutagenesis by allelic exchange of choE, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi. J Bacteriol 183(16):4796–4805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  91. Ladrón N, Fernández M, Agüero J, Zörn BG, Vázquez-Boland JA, Navas J (2003) Rapid identification of Rhodococcus equi by a PCR assay targeting the choE gene. J Clin Microbiol 41(7):3241–3245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Táncsics A, Szoboszlay S, Kriszt B, Kukolya J, Baka E, Márialigeti K et al (2008) Applicability of the functional gene catechol 1, 2-dioxygenase as a biomarker in the detection of BTEX-degrading Rhodococcus species. J Appl Microbiol 105(4):1026–1033

    Article  CAS  PubMed  Google Scholar 

  93. Duquesne F, Houssin E, Sévin C, Duytschaever L, Tapprest J, Fretin D et al (2017) Development of a multilocus sequence typing scheme for Rhodococcus equi. Vet Microbiol 210:64–70

    Article  CAS  PubMed  Google Scholar 

  94. Fatahi-Bafghi M (2018) Nocardiosis from 1888 to 2017. Microb Pathog 114:369–384

    Article  PubMed  Google Scholar 

  95. Steingrube VA, Wilson RW, Brown BA, Jost K, Blacklock Z, Gibson JL et al (1997) Rapid identification of clinically significant species and taxa of aerobic actinomycetes, including Actinomadura, Gordona, Nocardia, Rhodococcus, Streptomyces, and Tsukamurella isolates, by DNA amplification and restriction endonuclease analysis. J Clin Microbiol 35(4):817–822

    CAS  PubMed  PubMed Central  Google Scholar 

  96. Lal A, Seshasayee ASN (2014) The impact of next-generation sequencing technology on bacterial genomics. A systems theoretic approach to systems and synthetic biology II: Analysis and Design of Cellular Systems. Springer, pp 31–58

  97. Sangal V, Goodfellow M, Jones AL, Schwalbe EC, Blom J, Hoskisson PA et al (2016) Next-generation systematics: an innovative approach to resolve the structure of complex prokaryotic taxa. Sci Rep 6:38392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  98. Achtman M, Wagner M (2008) Microbial diversity and the genetic nature of microbial species. Nat Rev Microbiol 6(6):431

    Article  CAS  PubMed  Google Scholar 

  99. Moore ER, Mihaylova SA, Vandamme P, Krichevsky MI, Dijkshoorn L (2010) Microbial systematics and taxonomy: relevance for a microbial commons. Res Microbiol 161(6):430–438

    Article  PubMed  Google Scholar 

  100. Jain S, Bloom BR, Hondalus MK (2003) Deletion of vapA encoding virulence associated protein a attenuates the intracellular actinomycete Rhodococcus equi. Mol Microbiol 50(1):115–128

    Article  CAS  PubMed  Google Scholar 

  101. Takai S, Hines SA, Sekizaki T, Nicholson VM, Alperin DA, Osaki M et al (2000) DNA sequence and comparison of virulence plasmids from Rhodococcus equi ATCC 33701 and 103. Infect Immun 68(12):6840–6847

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Byrne BA, Prescott JF, Palmer GH, Takai S, Nicholson VM, Alperin DC et al (2001) Virulence plasmid of Rhodococcus equi contains inducible gene family encoding secreted proteins. Infect Immun 69(2):650–656

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  103. Tan C, Prescott J, Patterson M, Nicholson V (1995) Molecular characterization of a lipid-modified virulence-associated protein of Rhodococcus equi and its potential in protective immunity. Can J Vet Res 59(1):51–59

    CAS  PubMed  PubMed Central  Google Scholar 

  104. Takai S, Sekizaki T, Ozawa T, Sugawara T, Watanabe Y, Tsubaki S (1991) Association between a large plasmid and 15-to 17-kilodalton antigens in virulent Rhodococcus equi. Infect Immun 59(11):4056–4060

    CAS  PubMed  PubMed Central  Google Scholar 

  105. Takai S, Watanabe Y, Ikeda T, Ozawa T, Matsukura S, Tamada Y et al (1993) Virulence-associated plasmids in Rhodococcus equi. J Clin Microbiol 31(7):1726–1729

    CAS  PubMed  PubMed Central  Google Scholar 

  106. Ocampo-Sosa AA, Lewis DA, Navas J, Quigley F, Callejo R, Scortti M et al (2007) Molecular epidemiology of Rhodococcus equi based on traA, vapA, and vapB virulence plasmid markers. J Infect Dis 196(5):763–769

    Article  CAS  PubMed  Google Scholar 

  107. Letek M, Ocampo-Sosa AA, Sanders M, Fogarty U, Buckley T, Leadon DP et al (2008) Evolution of the Rhodococcus equi vap pathogenicity island seen through comparison of host-associated vapA and vapB virulence plasmids. J Bacteriol 190(17):5797–5805

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Valero-Rello A, Hapeshi A, Anastasi E, Alvarez S, Scortti M, Meijer WG et al (2015) An invertron-like linear plasmid mediates intracellular survival and virulence in bovine isolates of Rhodococcus equi. Infect Immun 83(7):2725–2737

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  109. Crespi M, Messens E, Caplan AB, Van Montagu M, Desomer J (1992) Fasciation induction by the phytopathogen Rhodococcus fascians depends upon a linear plasmid encoding a cytokinin synthase gene. EMBO J 11(3):795–804

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  110. Larkin MJ, Kulakov LA, Allen CC (2005) Biodegradation and Rhodococcus-masters of catabolic versatility. Curr Opin Biotechnol 16(3):282–290

    Article  CAS  PubMed  Google Scholar 

  111. Murai N (1981) Cytokinin biosynthesis and its relationship to the presence of plasmids in strains of Corynebacterium fascians. Metabolism and molecular activities of cytokinins: Springer. p. 17–26

    Google Scholar 

  112. Reh M, Schlegel H (1981) Hydrogen autotrophy as a transferable genetic character of Nocardia opaca 1b. Microbiology 126(2):327–336

    Article  CAS  Google Scholar 

  113. Dabbs ER, Sole GJ (1988) Plasmid-borne resistance to arsenate, arsenite, cadmium, and chloramphenicol in a Rhodococcus species. Mol Gen Genet 211(1):148–154

    Article  CAS  PubMed  Google Scholar 

  114. Desomer J, Dhaese P, Van Montagu M (1988) Conjugative transfer of cadmium resistance plasmids in Rhodococcus fascians strains. J Bacteriol 170(5):2401–2405

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  115. Dabbs ER, Gowan B, Andersen SJ (1990) Nocardioform arsenic resistance plasmids and construction of Rhodococcus cloning vectors. Plasmid 23(3):242–247

    Article  CAS  PubMed  Google Scholar 

  116. Singer M, Finnerty W (1988) Construction of an Escherichia coli-Rhodococcus shuttle vector and plasmid transformation in Rhodococcus spp. J Bacteriol 170(2):638–645

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  117. Kitagawa W, Mitsuhashi S, Hata M, Tamura T (2018) Identification of a novel bacteriocin-like protein and structural gene from Rhodococcus erythropolis JCM 2895, using suppression-subtractive hybridization. J Antibiot. https://doi.org/10.1038/s41429-018-0078-3

    Article  CAS  PubMed  Google Scholar 

  118. Petrovski S, Dyson ZA, Seviour RJ, Tillett D (2012) Small but sufficient: the Rhodococcus phage RRH1 has the smallest known Siphoviridae genome at 14.2 kilobases. Virol J 86(1):358–363

    Article  CAS  Google Scholar 

  119. Riverin M, Beaudoin J, Vezina C (1970) Characterization of a nocardiophage for Nocardia restrictus. J Gen Virol 6(3):395–407

    Article  CAS  PubMed  Google Scholar 

  120. Shibayama Y, Dabbs ER (2011) Phage as a source of antibacterial genes: multiple inhibitory products encoded by Rhodococcus phage YF1. Bacteriophage 1(4):195–197

    Article  PubMed  PubMed Central  Google Scholar 

  121. Salifu SP, Valero-Rello A, Campbell SA, Inglis NF, Scortti M, Foley S et al (2013) Genome and proteome analysis of phage E3 infecting the soil-borne actinomycete Rhodococcus equi. Environ Microbiol Rep 5(1):170–178

    Article  CAS  PubMed  Google Scholar 

  122. Petrovski S, Seviour RJ, Tillett D (2013) Genome sequence and characterization of a Rhodococcus equi phage REQ1. Virus Genes 46(3):588–590

    Article  CAS  PubMed  Google Scholar 

  123. Orchard I, Robert C. Genomic analysis of Burkholderia and Rhodococcus equi bacteriophages. 2011; http://hdl.handle.net/1969.1/98364

    Google Scholar 

  124. Salifu SP, Casey S, Foley S (2013) Isolation and characterization of soilborne virulent bacteriophages infecting the pathogen Rhodococcus equi. J Appl Microbiol 114(6):1625–1633

    Article  CAS  PubMed  Google Scholar 

  125. Petrovski S, Seviour RJ, Tillett D (2013) Characterization and whole genome sequences of the Rhodococcus bacteriophages RGL3 and RER2. Arch Virol 158(3):601–609

    Article  CAS  PubMed  Google Scholar 

  126. Bonilla JA, Isern S, Findley AM, Klyczek KK, Michael SF, Saha MS et al (2017) Genome sequences of 19 Rhodococcus erythropolis cluster CA phages. Genome Announc 5(49):e01201–e01217

    Article  PubMed  PubMed Central  Google Scholar 

  127. Brownell G, Adams J, Bradley S (1967) Growth and characterization of nocardiophages for Nocardia canicruria and Nocardia erythropolis mating types. J Microbiol 47(2):247–256

    CAS  Google Scholar 

  128. Dabbs ER (1987) A generalised transducing bacteriophage for Rhodococcus erythropolis. Mol Gen Genet 206(1):116–120

    Article  CAS  Google Scholar 

  129. Gill JJ, Wang B, Sestak E, Young R, Chu K-H (2018) Characterization of a novel Tectivirus phage toil and its potential as an agent for biolipid extraction. Sci Rep 8(1):1062

    Article  PubMed  PubMed Central  Google Scholar 

  130. Hiddema R, Curran M, Ferreira N, Coetzee J, Lecatsas G (1985) Characterization of phages derived from strains of Rhodococcus australis and R. equii. Intervirology 23(2):109–111

    Article  CAS  PubMed  Google Scholar 

  131. Austin MC, Hallstrand TS, Hoogestraat DR, Balmforth G, Stephens K, Butler-Wu S et al (2016) Rhodococcus fascians infection after haematopoietic cell transplantation: not just a plant pathogen? JMM Case Rep 3(2):e005025

    Article  PubMed  PubMed Central  Google Scholar 

  132. Golub B, Falk G, Spink WW (1967) Lung abscess due to Corynebacterium equi report of first human infection. Ann Intern Med 66(6):1174–1177

    Article  CAS  PubMed  Google Scholar 

  133. Verville TD, Huycke MM, Greenfield RA, Fine DP, Kuhls TL, Slater LN (1994) Rhodococcus equi infections of humans. 12 cases and a review of the literature. Medicine 73(3):119–132

    Article  CAS  PubMed  Google Scholar 

  134. Samies JH, Hathaway BN, Echols RM, Veazey JM, Pilon VA (1986) Lung abscess due to Corynebacterium equi. Report of the first case in a patient with acquired immune deficiency syndrome. Am J Med 80(4):685–688

    Article  CAS  PubMed  Google Scholar 

  135. Meijer WG, Prescott JF (2004) Rhodococcus equi. J Vet Res 35(4):383–396

    Article  CAS  Google Scholar 

  136. Prescott JF (1991) Rhodococcus equi: an animal and human pathogen. Clin Microbiol Rev 4(1):20–34

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. Ebersole LL, Paturzo JL (1988) Endophthalmitis caused by Rhodococcus equi Prescott serotype 4. J Clin Microbiol 26(6):1221

    CAS  PubMed  PubMed Central  Google Scholar 

  138. Müller F, Schaal KP, von Graevenitz A, Von Moos L, Woolcock J, Wüst J et al (1988) Characterization of Rhodococcus equi-like bacterium isolated from a wound infection in a noncompromised host. J Clin Microbiol 26(4):618–620

    PubMed  PubMed Central  Google Scholar 

  139. Hart D, Andrew J, Peel M, Burdon J (1988) Lung infection caused by Rhodococcus. Intern Med J 18(6):790–791

    CAS  Google Scholar 

  140. Novak R, Polisky EL, Janda W, Libertin CR (1988) Osteomyelitis caused by Rhodococcus equi in a renal transplant recipient. Infection 16(3):186–188

    Article  CAS  PubMed  Google Scholar 

  141. Brown E, Hendler E (1989) Rhodococcus peritonitis in a patient treated with peritoneal dialysis. J Am Soc Nephrol 14(5):417–418

    CAS  Google Scholar 

  142. Gopaul D, Ellis C, Maki A, Joseph MG (1988) Isolation of Rhodococcus rhodochrous from a chronic corneal ulcer. Diagn Microbiol Infect Dis 10(3):185–190

    Article  CAS  PubMed  Google Scholar 

  143. Hillerdal G, Riesenfeldt-örn I, Pedersen A, Ivanicova E (1988) Infection with Rhodococcus equi in a patient with sarcoidosis treated with corticosteroids. Scand J Infect Dis 20(6):673–677

    Article  CAS  PubMed  Google Scholar 

  144. Obana WG, Scannell KA, Jacobs R, Greco C, Rosenblum ML (1991) A case of Rhodococcus equi brain abscess. Surg Neurol 35(4):321–324

    Article  CAS  PubMed  Google Scholar 

  145. Martin T, Hogan DJ, Murphy F, Natyshak I, Ewan EP (1991) Rhodococcus infection of the skin with lymphadenitis in a nonimmunocompromised girl. J Am Acad Dermatol 24(2):328–332

    Article  CAS  PubMed  Google Scholar 

  146. Severo L, Petrillo V, Coutinho L (1987) Actinomycetoma caused by Rhodococcus spp. Mycopathologia 98(3):129–131

    Article  CAS  PubMed  Google Scholar 

  147. Byard RW, Thorner PS, Edwards V, Greenberg M (1990) Pulmonary malacoplakia in a child. Pediatr Pathol 10(3):417–424

    Article  CAS  PubMed  Google Scholar 

  148. L-x C, L-n G, Y-b H, B-l Z, J-y L (2018) Purulent meningitis caused by Rhodococcus equi: a case report. Medicine 97(24):e11156

    Article  Google Scholar 

  149. Zhang Y, Zhou F, Jiang Z, Jin M, Xu J (2016) Rhodococcus equi infection in patient with diffuse large B-cell lymphoma: report of a case. Zhonghua Bing Li Xue Za Zhi 45(12):877–878

    CAS  PubMed  Google Scholar 

  150. Baba H, Nada T, Ohkusu K, Ezaki T, Hasegawa Y, Paterson DL (2009) First case of bloodstream infection caused by Rhodococcus erythropolis. J Clin Microbiol 47(8):2667–2669

    Article  PubMed  PubMed Central  Google Scholar 

  151. Magnusson H (1923) Spezifische infektionse Pneumonie beim Fohlen. Ein neuer Eiterreger beim Pferd. Arch Wiss Prakt Tierhelkd 50:22–38

    Google Scholar 

  152. Prescott J (1987) Epidomiology of Rhodococcus equi infection in horses. Vet Microbiol 14(3):211–214

    Article  CAS  PubMed  Google Scholar 

  153. Magnusson H (1938) Pyaemia in foals caused by Corynebacterium equi. Vet Res 50:1459–1468

    Google Scholar 

  154. Rajagopalan V, Gopalakrishnan V (1938) The occurrence of Corynebacterium equi in a she-buffalo. IGVS 8:225–284

    Google Scholar 

  155. Craig J, Davies G (1940) Corynebacterium equi in bovine Pyometra. Vet J 96:417–419

    Google Scholar 

  156. Holtman DF (1945) Corynebacterium equi in chronic pneumonia of the calf. J Bacteriol 49(2):159–162

    CAS  PubMed  PubMed Central  Google Scholar 

  157. Woodroofe GM (1950) Studies on strains of Corynebacterium equi isolated from pigs. Aust J Exp Biol Med Sci 28:399–409

    Article  CAS  PubMed  Google Scholar 

  158. Neave R (1951) An outbreak of ulcerative lymphangitis in young heifers in Kenya. Vet Rec 63(10):185

    Article  CAS  PubMed  Google Scholar 

  159. Roberts D (1957) Corynebacterium equi infection in a sheep. Aust Vet J 33(1):21–21

    Article  Google Scholar 

  160. Rahman A (1957) The sensitivity of various bacteria to chemotherapeutic agents. Br Vet J 113(4):175–188

    Article  Google Scholar 

  161. Dennis S, Bamford V (1966) The rôle of corynebacteria in perinatal lamb mortality. Vet Rec 79(4):105–108

    Article  CAS  PubMed  Google Scholar 

  162. Jasmin A, Carroll J, Baucom J (1969) Corynebacterium equi infection in the American alligator (Alligator missippiensis) and the American crocodile (Crocodilus acutus). J Comp Lab Med 3:71–72

    Google Scholar 

  163. Jang S, Lock A, Biberstein E (1975) A cat with Corynebacterium equi lymphadenitis clinically simulating lymphosarcoma. Cornell Vet 65(2):232–239

    CAS  PubMed  Google Scholar 

  164. Stein F, Stott G (1979) Corynebacterium equi in the cottontop marmoset (Saguinus oedipus): a case report. Lab Anim Sci 29(4):519–520

    CAS  PubMed  Google Scholar 

  165. Prescott J, Zubaidy A (1979) Corynebacterium equi lymphadenitis in Ontario cattle. Can Vet J 20(6):175

    CAS  PubMed  PubMed Central  Google Scholar 

  166. Prescott J (1981) Capsular serotypes of Corynebacterium equi. Can J Comp Med 45(2):130

    CAS  PubMed  PubMed Central  Google Scholar 

  167. Rahman H, Baxi K (1983) Corynebacterium equi in mastitis in a buffalo (Bubalus bubalis)(correspondence)[bacterial disease]. Vet Rec

  168. Garg D, Kapoor P (1986) Isolation and characterization of Rhodococcus (Corynebacterium) equi from cows with mastitis. Indian J Comp Microbiol Immunol Infect Dis 7(2/3):91–95

    Google Scholar 

  169. Perdrizet J, Scott D (1987) Cellulitis and subcutaneous abscesses caused by Rhodococcus equi infection in a foal. J Am Vet Med Assoc 190(12):1559–1561

    CAS  PubMed  Google Scholar 

  170. Oxenford C, Ratcliffe R, Ramsay G (1987) Rhodococcus equi infection in a cat. Aust Vet J 64(4):121

    Article  CAS  PubMed  Google Scholar 

  171. Bauwens L, Van Dyck E, DeMeurichy W, Piot P (1987) Corynebacterium equi pneumonia in three Baikal seals (Pusa sibirica). Aquat Mamm 13:17–22

    Google Scholar 

  172. Carman M, Hodges R (1987) Distribution of Rhodococcus equi in animals, birds and from the environment. N Z Vet J 35(7):114–115

    Article  CAS  PubMed  Google Scholar 

  173. Yager J (1987) The pathogenesis of Rhodococcus equi pneumonia in foals. Vet Microbiol 14(3):225–232

    Article  CAS  PubMed  Google Scholar 

  174. Carrigan M, Links I, Morton A (1988) Rhodococcus equi infection in goats. Aust Vet J 65(10):331–332

    Article  CAS  PubMed  Google Scholar 

  175. Cantor GH, Byrne BA, Hines SA, Richards H III (1998) VapA-negative Rhodococcus equi in a dog with necrotizing pyogranulomatous hepatitis, osteomyelitis, and myositis. J Vet Diagn Investig 10(3):297–300

    Article  CAS  Google Scholar 

  176. Fairley R, Fairley N (1999) Rhodococcus equi infection of cats. Vet Dermatol 10:43–46

    Article  PubMed  Google Scholar 

  177. Patel A (2002) Pyogranulomatous skin disease and cellulitis in a cat caused by Rhodococcus equi. J Small Anim Pract 43(3):129–132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  178. Vengust M, Stæmpfli H, Prescott JF (2002) Rhodococcus equi pleuropneumonia in an adult horse. Can Vet J 43(9):706–708

    PubMed  PubMed Central  Google Scholar 

  179. Passamonti F, Lepri E, Coppola G, Sforna M, Proietti PC, Chiodetti I et al (2011) Pulmonary rhodococcosis in a cat. J Feline Med Surg 13(4):283–285

    Article  PubMed  Google Scholar 

  180. Karlson AG, Moses HE, Feldman WH (1940) Corynebacterium equi (Magnusson, 1923) in the submaxillary lymph nodes of swine. J Infect Dis 67:243–251

    Article  Google Scholar 

  181. Takai S, Takeuchi T, Tsubaki S (1986) Isolation of Rhodococcus (Corynebacterium) equi and atypical mycobacteria from the lymph nodes of healthy pigs. Jpn J Vet Sci 48(2):445–448

    Article  CAS  Google Scholar 

  182. de Morais ABC, Bolaños CAD, Alves AC, Ikuta CY, Lara GHB, Heinemann MB et al (2018) Identification of Mycobacterium species and Rhodococcus equi in peccary lymph nodes. Trop Anim Health Prod 50(6):1319–1326

    Article  PubMed  Google Scholar 

  183. Giles C, Vanniasinkam T, Ndi S, Barton M (2015) Rhodococcus equi (Prescottella equi) vaccines; the future of vaccine development. Equine Vet J 47(5):510–518

    Article  CAS  PubMed  Google Scholar 

  184. Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS et al (2018) Antibody to poly-N-acetyl glucosamine provides protection against intracellular pathogens: mechanism of action and validation in horse foals challenged with Rhodococcus equi. PLoS Pathog 14(7):e1007160

    Article  PubMed  PubMed Central  Google Scholar 

  185. Lacey MS (1936) Studies in bactemosis. XXII. Ann Appl Biol 23(2):302–310

    Article  Google Scholar 

  186. Crespi M, Vereecke D, Temmerman W, Van Montagu M, Desomer J (1994) The fas operon of Rhodococcus fascians encodes new genes required for efficient fasciation of host plants. J Bacteriol 176(9):2492–2501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  187. Stamler RA, Kilcrease J, Kallsen C, Fichtner EJ, Cooke P, Heerema RJ et al (2015) First report of Rhodococcus isolates causing pistachio bushy top syndrome on ‘UCB-1’rootstock in California and Arizona. Plant Dis 99(11):1468–1476

    Article  CAS  PubMed  Google Scholar 

  188. Hietala S, Ardans A (1987) Interaction of Rhodococcus equi with phagocytic cells from R. equi-exposed and non-exposed foals. Vet Microbiol 14(3):307–320

    Article  CAS  PubMed  Google Scholar 

  189. Drancourt M, Bonnet E, Gallais H, Peloux Y, Raoult D (1992) Rhodococcus equi infection in patients with AIDS. J Inf Secur 24(2):123–131

    CAS  Google Scholar 

  190. Sawai H, Sumi Y, Kurano S, Gondaira S, Kato Y, Tomiyasu I et al (1987) Granuloma formation by the glycolipids containing mycolic acid in Nocardia, Rhodococcus and related actinomycetes and their structure analysis. Yakugaku Zasshi 107(1):37–45

    Article  CAS  PubMed  Google Scholar 

  191. McNeil MM, Brown JM (1994) The medically important aerobic actinomycetes: epidemiology and microbiology. Clin Microbiol Rev 7(3):357–417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  192. Smola J, Katerov V, Schalen C (1994) Haemolytic and phospholipase C (PLC) activities of Rhodococcus equi. J Appl Microbiol 77(3):325–333

    CAS  Google Scholar 

  193. Pei Y, Dupont C, Sydor T, Haas A, Prescott JF (2006) Cholesterol oxidase (ChoE) is not important in the virulence of Rhodococcus equi. Vet Microbiol 118(3–4):240–246

    Article  CAS  PubMed  Google Scholar 

  194. Wall DM, Duffy PS, DuPont C, Prescott JF, Meijer WG (2005) Isocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi. Infect Immun 73(10):6736–6741

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  195. Pei Y, Parreira V, Nicholson VM, Prescott JF (2007) Mutation and virulence assessment of chromosomal genes of Rhodococcus equi 103. Can J Vet Res 71(1):1–7

    CAS  PubMed  PubMed Central  Google Scholar 

  196. Ren J, Prescott JF (2004) The effect of mutation on Rhodococcus equi virulence plasmid gene expression and mouse virulence. Vet Microbiol 103(3–4):219–230

    Article  CAS  PubMed  Google Scholar 

  197. Sangal V, Jones AL, Goodfellow M, Sutcliffe IC, Hoskisson PA (2014) Comparative genomic analyses reveal a lack of a substantial signature of host adaptation in Rhodococcus equi (‘Prescottella equi’). Pathog Dis 71(3):352–356

    Article  CAS  PubMed  Google Scholar 

  198. Stange R, Jeffares D, Young C, Scott D, Eason J, Jameson P (1996) PCR amplification of the fas-1 gene for the detection of virulent strains of Rhodococcus fascians. Plant Pathol 45(3):407–417

    Article  CAS  Google Scholar 

  199. Nakazawa M, Kubo M, Sugimoto C, Isayama Y (1983) Serogrouping of Rhodococcus equi. Microbiol Immunol 27(10):837–846

    Article  CAS  PubMed  Google Scholar 

  200. Lämmler C, Zimmermann B, Fuhrmann C (1997) Serological properties of Rhodococcus equi isolates of various origins determined with two typing systems. Med Sci Res. 25(3):187–189

    Google Scholar 

  201. Ivshina I, Kevorkov N (1982) Identification of bacteria belonging to the genus Rhodococcus using the technique of immunodiffusion. Mikrobiologiya 51(4):636–641

    Google Scholar 

  202. Ivshina I, Koblova I, Bezmaternykh G, Nesterenko O, Kvasnikov E, Shkaruba V (1986) The identification of bacteria of the genus Rhodococcus by immunodiffusion. Mikrobiol Zh 48(2):3–8

    CAS  PubMed  Google Scholar 

  203. Lammler C (1995) A rapid slide coagglutination test for the serological identification of Rhodococcus equi. Med Sci Res 23(9):637–638

    Google Scholar 

  204. Takai S, Kawazu S, Tsubaki S (1985) Enzyme-linked immunosorbent assay for diagnosis of Corynebacterium (Rhodococcus) equi infection in foals. Am J Vet Res 46(10):2166–2170

    CAS  PubMed  Google Scholar 

  205. Prescott J, Fernandez A, Nicholson V, Patterson M, Yager J, Viel L et al (1996) Use of a virulence-associated protein based enzyme-linked immunosorbent assay for Rhodococcus equi serology in horses. Equine Vet J 28(5):344–349

    Article  CAS  PubMed  Google Scholar 

  206. Jacobsen BN (1995) A method for quantification of Rhodococcus chlorophenolicus in activated sludge by immunofluorescence microscopy. Water Res 29(1):279–283

    Article  CAS  Google Scholar 

  207. Scortichini M, Todisco C, Varvaro L (1990) Specificity of antisera against Rhodococcus fascians (Tilford) Goodfellow in indirect immunofluorescence. J Phytopathol 129(4):327–332

    Article  Google Scholar 

  208. Clinical and Laboratory Standards Institute (2011) Susceptibility testing of mycobacteria, Nocardia and other aerobic actinomycetes. Approved standard, second edition. CLSI document M24–A2. Clinical and Laboratory Standards Institute, Wayne

    Google Scholar 

  209. Berghaus LJ, Giguère S, Guldbech K, Warner E, Ugorji U, Berghaus RD (2015) Comparison of Etest, disk diffusion, and broth macrodilution for in vitro susceptibility testing of Rhodococcus equi. J Clin Microbiol 53(1):314–318

    Article  CAS  PubMed  Google Scholar 

  210. Cisek AA, Rzewuska M, Witkowski L, Binek M (2014) Antimicrobial resistance in Rhodococcus equi. Acta Biochim Pol 61(4):633–638

    PubMed  Google Scholar 

  211. Weinstock DM, Brown AE (2002) Rhodococcus equi: an emerging pathogen. Clin Infect Dis 34(10):1379–1385

    Article  PubMed  Google Scholar 

  212. Gilbert DN, Moellering RC, Sande MA (2010) The sanford guide to antimicrobial therapy, 40th edn. Sperryville, Antimicrobial Therapy

    Google Scholar 

  213. Yamshchikov AV, Schuetz A, Lyon GM (2010) Rhodococcus equi infection. Lancet Infect Dis 10(5):350–359

    Article  PubMed  Google Scholar 

  214. Javed R, Taku A, Sharma R, Badroo GA (2017) Molecular characterization of Rhodococcus equi isolates in equines. Vet World 10(1):6–10

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  215. Gundelly P, Suzuki Y, Ribes JA, Thornton A (2016) Differences in Rhodococcus equi infections based on immune status and antibiotic susceptibility of clinical isolates in a case series of 12 patients and cases in the literature. Biomed Res Int. https://doi.org/10.1155/2016/2737295

    Article  CAS  Google Scholar 

  216. McNeil M, Brown J (1992) Distribution and antimicrobial susceptibility of Rhodococcus equi from clinical specimens. Eur J Epidemiol 8(3):437–443

    Article  CAS  PubMed  Google Scholar 

  217. Asoh N, Watanabe H, Fines-Guyon M, Watanabe K, Oishi K, Kositsakulchai W et al (2003) Emergence of rifampin-resistant Rhodococcus equi with several types of mutations in the rpoB gene among AIDS patients in northern Thailand. J Clin Microbiol 41(6):2337–2340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  218. Burton AJ, Giguère S, Sturgill TL, Berghaus LJ, Slovis NM, Whitman JL et al (2013) Macrolide-and rifampin-resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA. J Emerg Infect Dis 19(2):282

    Article  Google Scholar 

  219. Giguère S, Cohen N, Keith Chaffin M, Slovis N, Hondalus M, Hines S et al (2011) Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals. J Vet Intern Med 25(6):1209–1220

    Article  PubMed  Google Scholar 

  220. Tsukamura M (1982) Numerical analysis of the taxonomy of nocardiae and rhodococci. Microbiol Immunol 26(12):1101–1119

    Article  CAS  PubMed  Google Scholar 

  221. Klatte S, Rainey FA, Kroppenstedt RM (1994) Transfer of Rhodococcus aichiensis Tsukamura 1982 and Nocardia amarae Lechevalier and Lechevalier 1974 to the genus Gordona as Gordona aichiensis comb. nov. and Gordona amarae comb. nov. Int J Syst Evol Microbiol 44(4):769–773

    CAS  Google Scholar 

  222. Tsukamura M, Yano I (1985) Rhodococcus sputi sp. nov., nom. rev., and Rhodococcus aurantiacus sp. nov., nom. rev. Int J Syst Evol Microbiol 35(3):364–368

    Google Scholar 

  223. Collins M, Smida J, Dorsch M, Stackebrandt E (1988) Tsukamurella gen. Nov. harboring Corynebacterium paurometabolum and Rhodococcus aurantiacus. Int J Syst Evol Microbiol 38(4):385–391

    CAS  Google Scholar 

  224. Apajalahti JH, Kärpänoja P, Salkinoja-Salonen MS (1986) Rhodococcus chlorophenolicus sp. nov., a chlorophenol-mineralizing actinomycete. Int J Syst Evol Microbiol 36(2):246–251

    CAS  Google Scholar 

  225. Hagglblom MM, Nohynek LJ, Palleroni NJ, Kronqvist K, Nurmiaho-Lassila E-L, Salkinoja-Salonen MS et al (1994) Transfer of Polychlorophenol-degrading Rhodococcus chlorophenolicus (Apajalahti et al. 1986) to the genus Mycobacterium as Mycobacterium chlorophenolicum comb. nov. Int J Syst Evol Microbiol 44(3):485–493

    CAS  Google Scholar 

  226. Riegel P, Kamne-Fotso M, De Briel D, Prevost G, Jehl F, Piemont Y et al (1994) Rhodococcus chubuensis Tsukamura 1982 is a later subjective synonym of Gordona sputi (Tsukamura 1978) Stackebrandt 1989 comb. nov. Int J Syst Evol Microbiol 44(4):764–768

    Google Scholar 

  227. Mordarski M, Goodfellow M, Kaszen I, Tkacz A, Pulverer G, Schaal K (1980) Deoxyribonucleic acid reassociation in the classification of the genus Rhodococcus Zopf 1891 (approved lists, 1980). Int J Syst Evol Microbiol 30(3):521–527

    Google Scholar 

  228. Nesterenko O, Nogina T, Kasumova S, Kvasnikov E, Batrakov S (1982) Rhodococcus luteus nom. nov. and Rhodococcus maris nom. nov. Int J Syst Evol Microbiol 32(1):1–14

    Google Scholar 

  229. Klatte S, Jahnke K-D, Kroppenstedt RM, Rainey F, Stackebrandt E (1994) Rhodococcus luteus is a later subjective synonym of Rhodococcus fascians. Int J Syst Evol Microbiol 44(4):627–630

    Google Scholar 

  230. Tsukamura M (1985) Priority of Rhodococcus lentifragmentus (Kruse 1896; Tsukamura et al. 1975) Tsukamura 1978 comb. nov. over Rhodococcus ruber (Kruse 1896) Goodfellow and Alderson 1980: request for an opinion. Int J Syst Evol Microbiol 35(1):124–125

    Google Scholar 

  231. Tsukamura M, Yano I, Kudo T, Miyama A (1991) Rhodococcus roseus sp. nov., nom. rev. Int J Syst Evol Microbiol 41(3):385–389

    Google Scholar 

  232. Rainey FA, Burghardt J, Kroppenstedt R, Klatte S, Stackebrandt E (1995) Polyphasic evidence for the transfer of Rhodococcus roseus to Rhodococcus rhodochrous. Int J Syst Evol Microbiol 45(1):101–103

    Google Scholar 

  233. Turfittge GE (1944) Microbiological agencies in the degradation of steroids: I. The cholesterol-decomposing organisms of soils. J Bacteriol 47(6):487

    Google Scholar 

  234. Morse ME (1912) A study of the diphtheria group of organisms by the biometrical method. J Infect Dis 11:253–285

    Article  Google Scholar 

  235. Eberson F (1918) A bacteriologic study of the diphtheroid organisms with special reference to Hodgkin's disease. J Infect Dis 23(1):1–42

    Article  Google Scholar 

  236. Jones AL, Sutcliffe IC, Goodfellow M (2013) Prescottia equi gen. nov., comb. nov.: a new home for an old pathogen. Antonie Van Leeuwenhoek 103(3):655–671

    Article  PubMed  Google Scholar 

  237. Jones AL, Sutcliffe IC, Goodfellow M (2013) Proposal to replace the illegitimate genus name Prescottia Jones et al. 2013 with the genus name Prescottella gen. nov. and to replace the illegitimate combination Prescottia equi Jones et al. 2013 with Prescottella equi comb. nov. Antonie Van Leeuwenhoek 103(6):1405–1407

    Article  PubMed  Google Scholar 

  238. Sangal V, Jones AL, Goodfellow M, Hoskisson PA, Kämpfer P, Sutcliffe IC (2015) Genomic analyses confirm close relatedness between Rhodococcus defluvii and Rhodococcus equi (Rhodococcus hoagii). Arch Microbiol 197(1):113–116

    Article  CAS  PubMed  Google Scholar 

  239. Garrity GM (2014) Conservation of Rhodococcus equi (Magnusson 1923) Goodfellow and Alderson 1977 and rejection of Corynebacterium hoagii (Morse 1912) Eberson 1918. Int J Syst Evol Microbiol 64(1):311–312

    Article  PubMed  Google Scholar 

  240. Tindall B (2014) The correct name of the taxon that contains the type strain of Rhodococcus equi. Int J Syst Evol Microbiol 64(1):302–308

    Article  CAS  PubMed  Google Scholar 

  241. Goodfellow M, Sangal V, Jones A, Sutcliffe I (2015) Charting stormy waters: a commentary on the nomenclature of the equine pathogen variously named Prescottella equi, Rhodococcus equi and Rhodococcus hoagii. Equine Vet J 47(5):508–509

    Article  CAS  PubMed  Google Scholar 

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  1. Department of Microbiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Mohadeseh Majidzadeh & Mehdi Fatahi-Bafghi

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  1. Mohadeseh Majidzadeh
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Majidzadeh, M., Fatahi-Bafghi, M. Current taxonomy of Rhodococcus species and their role in infections. Eur J Clin Microbiol Infect Dis 37, 2045–2062 (2018). https://doi.org/10.1007/s10096-018-3364-x

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