Skip to main content
SpringerLink
Log in

Application of guidelines for aminoglycosides use in French hospitals in 2013–2014

  • Original Article
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

In 2011, the French Agency for Safety of Health Products issued guidelines underlining the principles of proper aminoglycosides’ use. The aim of the survey was to evaluate adherence to these guidelines two years after their issue. Characteristics of patients receiving aminoglycosides were recorded by voluntary facilities during a 3-month survey in 2013–2014. The modalities of aminoglycosides treatment were analysed by comparison with the French guidelines. A total of 3,323 patients were included by 176 facilities. Patients were mainly hospitalized in medical wards (33.0%), and treated for urinary-tract infections (24.7%). Compliance regarding the clinical indication and the daily aminoglycosides dose was observed in 65.2% and 62.9% of the cases, respectively. A 30-min once-daily IV administration was recorded in 62.5% of the cases. Aminoglycosides treatment duration was appropriate (≤5 days) for 93.6% of the patients. When considering the four criteria together, 23.2% of the patients had a treatment regimen aligned with the guidelines. Requests for measurements of peak and trough AG serum concentrations matched the guidelines in 24.9% and 67.4% of the cases, respectively. Two years after guidelines issue, aminoglycosides use remains unsatisfactory in French health-care facilities. Efforts should be made for guidelines promotion, especially regarding the issue of underdosing.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Moore RD, Lietman PS, Smith CR (1987) Clinical response to aminoglycoside therapy: importance of the ratio of peak concentration to minimal inhibitory concentration. J Infect Dis 155:93–99. doi:10.1093/infdis/155.1.93

    Article  CAS  PubMed  Google Scholar 

  2. Zelenitsky SA, Harding GKM, Sun S, Ubhi K, Ariano RE (2003) Treatment and outcome of pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis. J Antimicrob Chemother 52:668–674. doi:10.1093/jac/dkg403

    Article  CAS  PubMed  Google Scholar 

  3. Chuck SK, Raber SR, Rodvold KA, Areff D (2000) National survey of extended-interval aminoglycoside dosing. Clin Infect Dis 30:433–439. doi:10.1086/313692

    Article  CAS  PubMed  Google Scholar 

  4. Leong CL, Buising K, Richards M, Robertson M, Street A (2006) Providing guidelines and education is not enough: an audit of gentamicin use at The Royal Melbourne Hospital. Intern Med J 36:37–42. doi:10.1111/j.1445-5994.2006.01002.x

    Article  CAS  PubMed  Google Scholar 

  5. Houot M, Pilmis B, Thepot-Seegers V, Suard C, Potier C, Postaire M et al (2016) Aminoglycoside use in a pediatric hospital: there is room for improvement-a before/after study. Eur J Pediatr 175(5):659–665. doi:10.1007/s00431-016-2691-0

    Article  CAS  PubMed  Google Scholar 

  6. Begg EJ, Vella-Brincat JWA, Robertshawe B, McMurtrie MJ, Kirkpatrick CMJ, Darlow B (2009) Eight years’ experience of an extended-interval dosing protocol for gentamicin in neonates. J Antimicrob Chemother 63:1043–1049. doi:10.1093/jac/dkp073

    Article  CAS  PubMed  Google Scholar 

  7. Anonymous (2012) Update on good use of injectable aminoglycosides, gentamicin, tobramycin, netilmicin, amikacin. Pharmacological properties, indications, dosage, and mode of administration, treatment monitoring. Méd Mal Infect 42:301–308. doi:10.1016/j.medmal.2011.07.007

    Article  Google Scholar 

  8. Nicolas-Chanoine M-H, Gruson C, Bialek-Davenet S, Bertrand X, Thomas-Jean F, Bert F et al (2013) 10-Fold increase (2006–11) in the rate of healthy subjects with extended-spectrum β-lactamase-producing Escherichia coli faecal carriage in a Parisian check-up centre. J Antimicrob Chemother 68:562–568. doi:10.1093/jac/dks429

    Article  CAS  PubMed  Google Scholar 

  9. Gupta K, Hooton TM, Naber KG, Wullt B, Colgan R, Miller LG et al (2011) International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 52:e103–e120. doi:10.1093/cid/ciq257

    Article  PubMed  Google Scholar 

  10. Fraisse T, Gras Aygon C, Paccalin M, Vitrat V, De Wazieres B, Baudoux V et al (2014) Aminoglycosides use in patients over 75 years old. Age Ageing 43:676–681. doi:10.1093/ageing/afu023

    Article  PubMed  Google Scholar 

  11. Taccone FS, Laterre P-F, Spapen H, Dugernier T, Delattre I, Layeux B et al (2010) Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock. Crit Care 14:R53. doi:10.1186/cc8945

    Article  PubMed  PubMed Central  Google Scholar 

  12. Barclay ML, Kirkpatrick CM, Begg EJ (1999) Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored? Clin Pharmacokinet 36:89–98. doi:10.2165/00003088-199936020-00001

    Article  CAS  PubMed  Google Scholar 

  13. Payne KD, Hall RG (2014) Dosing of antibacterial agents in obese adults: does one size fit all? Expert Rev Anti Infect Ther 12:829–854. doi:10.1586/14787210.2014.912942

    Article  CAS  PubMed  Google Scholar 

  14. Pai MP, Nafziger AN, Bertino JS (2011) Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients. Antimicrob Agents Chemother 55:4006–4011. doi:10.1128/AAC.00174-11

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Polso AK, Lassiter JL, Nagel JL (2014) Impact of hospital guideline for weight-based antimicrobial dosing in morbidly obese adults and comprehensive literature review. J Clin Pharm Ther 39:584–608. doi:10.1111/jcpt.12200

    Article  CAS  PubMed  Google Scholar 

  16. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C et al (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384:766–781. doi:10.1016/S0140-6736(14)60460-8

    Article  PubMed  PubMed Central  Google Scholar 

  17. Gonçalves-Pereira J, Martins A, Póvoa P (2010) Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose. Clin Microbiol Infect 16:1258–1263. doi:10.1111/j.1469-0691.2009.03074.x

    Article  PubMed  Google Scholar 

  18. Bertino JS, Booker LA, Franck PA, Jenkins PL, Franck KR, Nafziger AN (1993) Incidence of and significant risk factors for aminoglycoside-associated nephrotoxicity in patients dosed by using individualized pharmacokinetic monitoring. J Infect Dis 167:173–179. doi:10.1093/infdis/167.1.173

    Article  PubMed  Google Scholar 

  19. Maller R, Ahrne H, Holmen C, Lausen I, Nilsson LE, Smedjegard J (1993) Once- versus twice-daily amikacin regimen: efficacy and safety in systemic Gram-negative infections. J Antimicrob Chemother 31:939–948. doi:10.1093/jac/31.6.939

    Article  CAS  PubMed  Google Scholar 

  20. Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud P-AC et al (1999) Why don’t physicians follow clinical practice guidelines? JAMA 282:1458. doi:10.1001/jama.282.15.1458

    Article  CAS  PubMed  Google Scholar 

  21. Gross PA, Pujat D (2001) Implementing practice guidelines for appropriate antimicrobial usage: a systematic review. Med Care 39:II55–II69

    CAS  PubMed  Google Scholar 

  22. Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ et al (2016) Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis 62:e51–77. doi:10.1093/cid/ciw118

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

In memoriam: Sandrine CLEMENT (www.neanima.fr). Our deepest sympathies go out to her family.

The Surveillance de la Prescription des Antibiotiques (SPA) group: name (facility, city)

P. ABGUEGUEN (CHU Angers, ANGERS), A. AKPABIE (Hôpital E. Roux - APHP, LIMEIL BREVANNES), S. ALFANDARI(CH Tourcoing, TOURCOING), P. ANDRE (Clinique du Millenaire, MONTPELLIER) (Polyclinique ST-Roch, MONTPELLIER), V. ANGELUS (Clinique L’Angelus, MARSEILLE), S. ARENA-CANAULT (Maternite Catholique Provence L’Etoile, AIX EN PROVENCE), A. ARREGUY (CH St-Palais, BAYONNE), N. BACHALAT (Hôpital Joffre - APHP, DRAVEIL), MT. BANOS (CH Lannemezan, LANNEMEZAN), P. BAUNE (Hôpital Charles Richet, VILLIERS LE BEL), O. BELLON (CH Brignoles, BRIGNOLES), M. BENAISSA (CH Apt, APT), N. BENICHOUGRANE (Hôpital Européen, MARSEILLE), G. BENISTAND (Polyclinique Grand-Sud, NIMES), F. BERGHEAU (Ch Pays de Gier, St CHAMOND), N. BERTRAND (Clinique Chantecler, MARSEILLE), C. BERTRAND (Clinique Rhone Durance, AVIGNON), C. BIANCHI (CHR Pontchaillou, RENNES), H. BLAISE (Clinique du Parc, NANTES), C. BONNAL (Hôpital Bretonneau - APHP PARIS), S. BORDES-COUECOU (CHIC Cote Basque, BAYONNE), A. BOUMEDIENE (CHCB Kerio, PLEMET), M. BOURLEAUD (CH de Bastia, BASTIA), S. BOURZEIX DE LAROUZIERE (CH Moulin Yzeure, MOULINS), D. BREGER (Clinique Sourdille, NANTES), C. BROCARD (Clinique Les Ormeaux, LE HAVRE), JP. BRU (CH Région d’Annecy, PRINGY), P. CABARET (ES St-Vincent de Paul, LILLE), P. CABARET (Hôpital St Philibert, LOMME), P. CABARET (Clinique Ste Marie, CAMBRAI), V. CADIOU (SLD Beauséjour, HYERES), B. CASTAN (CH ND la Miséricorde, AJACCIO), B. CATTIER (CH Amboise-Chateaurenault, AMBOISE), C. CAZORLA (CHU Saint-Etienne, ST ETIENNE), D. CERVONI (Centre Les Arbelles, BOURG EN BRESSE), M. CHADAPAUD (CH MJ. Treffot, HYERES), C. CHAIX (CH Carpentras, CARPENTRAS), C. CHAUVET (CH Montélimar, MONTELIMAR), P. CIPIERRE (Clinique du Parc, PERIGUEUX), M. CLIQUENOIS (Hôpital de L’Isle-Adam, L’ISLE ADAM), Y. COLIN (Centre Medical L’Arbizon, BAGNERES DE BIGORRE), S. COMPAROT (CH L. Giorgi, ORANGE), O. CORBELLI (Clinique Vignoli SALON DE PROVENCE), N. CORDAT (Clinique du Val de l’Ouest, ECULLY), S. CORMONT (Hôpital de Felleries Liessies, FELLERIES), M. CORNESSE (Hôpital Beauregard, MARSEILLE), F. COULOMB (CH Dreux, DREUX), J. CROUZET (CH Pasteur, BAGNOLS SUR CEZE), J. DARASTEANU (CH Chartres, CHARTRES), M. DAUMAS (CH Imbert Joseph, ARLES), MH. DEBOISSE (Clinique du Colombier, LIMOGES), C. DEBRUILLE (CH Douai, DOUAI), B. DECOUARD (MSPBx Bagatelle, TALENCE), S. DEFRETIN (Clinique St-Roch, RONCQ), B. DEGRENDEL (Centre Sainte Clotilde, STE CLOTILDE), J. DELHOMME (CHIC Alencon-Mamers, ALENCON), G. DELHON BUGARD (Clinique Charcot, STE FOY LES LYON), G. DEMELIN (Hôpital Thiais, THIAIS), A. DEMOUZON (EPDS de Gorze, GORZE), E. DEVAUD (CH R. Dubos, PONTOISE), S. DEWULF (CH Zuydcoote, ZUYDCOOTE), A. DINH (Hôpital R. Poincaré - APHP, GARCHES), C. DOMRAULT-TANGUY (CH Henin Beaumont, HENIN BEAUMONT), F. DOMY (Clinique Trenel, STE COLOMBE), F. DOUCET-POPULAIRE (Hôpital A. Beclere - APHP, CLAMART), L. DRIEUX-ROUZET (Hôpital Charles Foix - APHP, IVRY SUR SEINE), M. DUVIQUET (Hôpital Vaugirard - APHP, PARIS), A. EDEN (CH Joffre, PERPIGNAN), S. EDOUARD (CH Dieppe, DIEPPE), L. EL-HAJJ (Clinique Convert, BOURG EN BRESSE), C. ELOY (CH Troyes, TROYES), M. EMONET (CH Blois, BLOIS), J. EPIFANIE (Centre E. Clémentel, ENVAL), L. ESCAUT (Hôpital Bicêtre - APHP, LE KREMLIN BICETRE), F. ESPINASSE (Hôpital Ambroise Paré - APHP, BOULOGNE BILLANCOURT), C. ETIENNE (CH Gaillac, GAILLAC), M. FABRE (CH P. Oudot, BOURGOIN-JALLIEU), V. FIHMAN (Hôpital Louis Mourier - APHP, COLOMBES), E. FORESTIER (CH Chambéry, CHAMBERY), D. FRAISSE (CH Ales, ALES), C. FRANCESCHI (Hôpital de Lunel, LUNEL), C. FUHRMANN (Centre Léon Bérard, LYON), M. GACHOT (Institut Gustave Roussy, VILLEJUIF), M. GAILLARD (CH E. Roux, LE PUY EN VELAY), B. GARO (CHRU Brest, BREST), R. GAUZIT (Hôpital Cochin - APHP, PARIS), P. GEROME (HIA Desgenettes, LYON), M. GILLMANN (CH Lemire-St-Avold, ST AVOLD), L. GIRAUDON (CH Sète, SETE), F. GLATH (Hôpital de Pompey/Lay St Christophe, POMPEY), P. GRANIER (CH Fleyriat, BOURG EN BRESSE), B. GRAVAGNA (Clinique Mutualiste de Lyon E.André et Union, LYON), A. GREDER-BELAN (CH Mignot, LE CHESNAY), F. GREIL (Centre réadaptation Revel, ST MAURICE / DARGOIRE), S. GROSSE (Hôpital St Maurice - Moyeuvre-Grande, MOYEUVRE GRANDE), C. GUERIN (SSR l’Amandier, CHATENAY MALABRY), C. GUIGNABERT (CH G. Ramon, SENS), M. GUILLAUME (CH Voiron, VOIRON), S. GUITTET (Pôle santé Léonard de Vinci, CHAMBRAY LES TOURS), S. HENARD (CHU Nancy, VANDOEUVRE LES NANCY), L. HENNEQUIN (Hôpital du Neuenberg, INGWILLER), P. HONDERLICK (Hôpital Foch, SURESNES), S. HONORE (CH Auxerre, AUXERRE), A. HUAULT (EMPR Le Normandy, GRANVILLE), A. HUOT (Clinique MC Chenove, CHENOVE), L. DUCRUET (CH Ain Val de Saône, PONT DE VEYLE), L. JEANNIN (Institut de Mar Vivo, LA SEYNE SUR MER), A. JULLIAN (Centre de rééducation cardio-respiratoire, DIEULEFIT), A. JUNG (Hôpital de Sarralbe, SARRALBE), N. KASSIS-CHIKHANI (Hôpital Paul Brousse - APHP, VILLEJUIF), E. LAFEUILLE, A. ADE (CHU Pitié-Salpêtrière - APHP, PARIS), LAGNIEN-GAUME (CH L. Pasteur, DOLE), C. LANTERNIER (Clinique des Alpes, GRENOBLE), C. LARTIZIEN (Hôpital maritime, BERCK), C. LAURANS (CH Roubaix, ROUBAIX), O. LAURENT (Clinique Guillaume de Varye, ST DOULCHARD & Clinique Le Blaudy, PRECY), C. LECHICHE (CHU Caremeau, NIMES 9), D. LECOINTE (GH P. Doumer, LIANCOURT), M. LECOQ (CH W Morey, CHALON SUR SAONE), N. LEFEBVRE (CHRU Strasbourg, STRASBOURG), A. LEFORT (Hôpital Beaujon - APHP, CLICHY), AM. LELOUP (DAPT de Châtillon, CHATILLON), R. LEPEULE (CHU A.Chenevier-H.Mondor - APHP, CRETEIL), T. LEVENT (Polyclinique Vauban, VALENCIENNES & CH Maubeuge, MAUBEUGE), A. LIGNEREUX (CH Gabriel Martin, ST PAUL), J. LIVARTOWSKI (Hôpital privé d’Antony, ANTONY), B. LOCTIN (Clinique de La Part-Dieu, LYON), V. LOUBERSAC (Clinique Breteche, NANTES), JC. LUCET (CHU Bichat - APHP, PARIS), C. MAC NAB (HIA Percy, CLAMART), F. MADOUMIE (Clinique des Emailleurs, LIMOGES), P. MAHE (CH F. Grall, LANDERNEAU), N. MARCHISET (CH d’Ambert, AMBERT), S. MARGUERY (Clinique Ste Marthe, DIJON), L. MARI (Centre de gérontologie de Montolivet, MARSEILLE), I. MARTIN (CH Roanne, ROANNE), C. MASSA (Clinique Montréal, CARCASSONNE), C. MATHERN (Hôpital de Creutzwald, CREUTZWALD), V. MATHIS (Association hospitalière de Joeuf, JOEUF), L. MAZZONI (Clinica Oxford, CANNES & Clinique Le Méridien, CANNES LA BOCCA), M. MELET (Polyclinique du Parc, CAEN), M. MELET (Clinique St-Jean Languedoc, Clinique Sarrus-Teinturiers & Clinique A. Pare, TOULOUSE), M. MERTZ (Hôpital de Billom, BILLOM), V. MESPLEDE (MRC Sainte Odile, BILLERE), A. MILESI-LECAT (CH Vichy, VICHY), R. MONTEIL (Hôpital Condat, CONDAT), P. MONTEIL (Médipole de Savoie, CHALLES LES EAUX), V. MOULIN (Hôpital Corentin Celton - APHP, ISSY LES MOULINEAUX), A. MOUNE (Clinique du Palais, GRASSE), E. MURET (Clinique St-George, NICE), PH. NAUDE (Maison de convalescence Les Elieux, SEICHAMPS), D. NAVAS (CHU Nantes, NANTES), G. NICOLAOS (CH Coulommiers, COULOMMIERS), JY. NIZOU (L’Institut Mutualiste Montsouris, PARIS), M. NOLL-BURGIN (GH St Vincent, STRASBOURG), C. NOWAK (CH Angoulême, ANGOULEME), M. OLEHAINI (CH Vierzon, VIERZON), O. PANTALONI (Clinique St-Pierre, PERPIGNAN), O. PATEY (CH Villeneuve-St-Georges, VILLENEUVE ST GEORGES), E. PONCET (Clinique La Source, ST LEGER LES MELEZES), F. POSPISIL (Polyclinique Synergia, CARPENTRAS), S. POULET (Polyclinique Les Fleurs, OLLIOULES) , G. RAHAL (Clinique Turin & Hôpital privé des Peupliers, PARIS), C. RAPP (HIA Begin, ST MANDE), S. RASTOUL (Clinique St-Louis, POISSY), S. RAYNAUD (Clinique médicale Monie, VILLEFRANCHE DE LAURAGAIS), J. REVEIL (CH Charleville Mezières, CHARLEVILLE MEZIERES), P. RIBELLE (Clinique Tivoli, BORDEAUX), A. RICARD (Clinique Richelieu, SAINTES), G. RONDELOT (CHR Metz-Thionville, HAYANGE), J. ROUSSEAU (Clinique de Cognac, COGNAC), O. SABOT (CH Belley, BELLEY), L. SAFONT, Polyclinique St-Privat, BOUJAN SUR LIBRON), M. SAREM (CH Sémur-en-Auxois, SEMUR EN AUXOIS), P. SAUTIER (HP Pays de Savoie, ANNEMASSE), L. SCHANG (Clinique St-Antoine, NICE), L. SENG (Clinique de Thorigny, SERRIS), V. SIMHA (Hôpital San Salvadour, HYERES), B. SIMPLOT (Hôpital de Lamarche, LAMARCHE), S. SIRE (CH Jean Rougier, CAHORS), M. SOULERIN (Clinique du Vivarais, AUBENAS), B. SOULLIE (HIA Robert Picque, VILLENAVE D’ORNON), C. SOUYRI (Centre de rééducation, CHAUDES AIGUES), JP. STAHL (CHU Grenoble, LA TRONCHE) J. TALARMIN (CH de Cornouaille, QUIMPER), V. TALPIN (Hôpital de La Clayette, LA CLAYETTE), V. TONNERRE (Clinique Mutualiste du Médoc, LESPARRE MEDOC), J. TRACOL (Centre chirurgical St-Roch, CAVAILLON), F. TURCHET (Clinique Belledonne, ST MARTIN D’HERES), F. VANDENBOS (La Maison du Mineur, VENCE), E. VAUTRIN (CH St-Dizier, ST DIZIER), N. VEISSE (Centre MGEN Pierre-Chevalier, HYERES), V. VERNET-GARNIER (CHU Reims, REIMS), M. VESANES (Hôpital du Marin, LE MARIN), R. VIAL (Hôpital de Beaujeu, BEAUJEU), F. VIELH (CH Le Secq de Crépy, BOULAY), P. VILLEMAIN (CH de St-Flour, ST FLOUR), P. VILLEMAIN (CH Aurillac, AURILLAC), P. VILLEMAIN (CH Thann, THANN), J. VIOT (Centre de convalescence Wilson, ANTIBES ; Clinique du Parc Impérial, NICE 1 & MC Magnolias, ST LAURENT DU VAR), M. VOGT (Clinique Ste-Odile, STRASBOURG), C. WATELET (Clinique SSR Chateau de Gleteins, JASSANS RIOTTIER), Tamarins (Clinique les Flamboyants & Clinique Les Tamarins, LE PORT).

Author information

Authors and Affiliations

  1. Centre d’Immunologie et des Maladies Infectieuses, CIMI, Team E13 (Bacteriology), Sorbonne Universités, UPMC Univ Paris 06, CR7, INSERM, U1135, 75013, Paris, France

    J. Robert

  2. AP-HP, Hôpitaux Universitaires Pitié Salpêtrière – Charles Foix, Bacteriology and Hygiene, 75013, Paris, France

    J. Robert

  3. Laboratoire de Bactériologie-Hygiène, Faculté de Médecine Pierre et Marie Curie (UPMC Paris 6), 91 Boulevard de l’hôpital, 75634, Paris 13, France

    J. Robert

  4. Observatoire National de l’Epidémiologie de la Résistance Bactérienne aux Antibiotiques (ONERBA), Paris, France

    Y. Péan

  5. Service de Réanimation et Maladies Infectieuses, CH Gustave Dron, Tourcoing, France

    S. Alfandari

  6. Infectious Diseases Department, CH de la Région d’Annecy, Annecy, France

    J.-P. Bru

  7. Intensive Care Unit, CH Henri Mignot de Versailles, Le Chesnay, France

    J.-P. Bedos

  8. Infectious Diseases Department, CHU de Nancy, Nancy, France

    C. Rabaud

  9. Intensive care Unit, CHU Cochin, APHP, Paris, France

    R. Gauzit

Authors
  1. J. Robert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. Péan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Alfandari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J.-P. Bru
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J.-P. Bedos
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. Rabaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Gauzit
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

on behalf of the Société de Pathologie Infectieuse de Langue Française (SPILF), the Observatoire National de l’Epidémiologie de la Résistance Bactérienne aux Antibiotiques (ONERBA) and the Surveillance de la Prescription des Antibiotiques (SPA) group

Corresponding author

Correspondence to J. Robert.

Ethics declarations

Funding

The Société de Pathologie Infectieuse de Langue Française (SPILF) provided financial support for data management.

Competing interests

The authors have no competing interests to declare.

Ethical approval

Not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Robert, J., Péan, Y., Alfandari, S. et al. Application of guidelines for aminoglycosides use in French hospitals in 2013–2014. Eur J Clin Microbiol Infect Dis 36, 1083–1090 (2017). https://doi.org/10.1007/s10096-016-2892-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-016-2892-5

Keywords

Search

Navigation