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The regulatory function of lncRNA and constructed network in epilepsy

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Abstract

Background

Epilepsy is a neurological disease characterized by neural network dysfunction. Although most reports indicate that the pathological process of epilepsy is related to inflammation, synaptic plasticity, cell apoptosis, and ion channel dysfunction, the underlying molecular mechanisms of epilepsy are not fully understood.

Methods

This review summarizes the latest literature on the roles and characteristics of long noncoding RNAs (lncRNAs) in the pathogenesis of epilepsy.

Results

lncRNAs are a class of long transcripts without protein-coding functions that perform important regulatory functions in various biological processes. lncRNAs are involved in the regulation of the pathological process of epilepsy and are abnormally expressed in both patients and animal models. This review provides an overview of research progress in epilepsy, the multifunctional features of lncRNAs, the lncRNA expression pattern related to epileptogenesis and status epilepticus, and the potential mechanisms for the two interactions contributing to epileptogenesis and progression.

Conclusion

lncRNAs can serve as new diagnostic markers and therapeutic targets for epilepsy in the future.

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Funding

This research was supported by the National Nature and Science Foundation of China (82071448, SL Liang) and Beijing Nature & Science Foundation of China (7202045, SL Liang). These funds were not involved in the study design, data collection and analysis, interpretation of data, or writing of the report.

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Authors and Affiliations

  1. Functional Neurosurgery Department, National Children’s Health Center of China, Beijing Children’s Hospital, Capital Medical University, Beijing, China

    Suhui Kuang, Jiaqi Wang, Zhirong Wei, Feng Zhai & Shuli Liang

  2. Key Laboratory of Major Diseases In Children, Ministry of Education, Beijing, China

    Shuli Liang

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  1. Suhui Kuang
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Shuli Liang: conceptualization, writing—reviewing and editing, and funding acquisition. Suhui Kuang, Jiaqi Wang, and Zhirong Wei: writing—original draft preparation, literature search, and analysis. Feng Zhai: writing—reviewing and editing. All authors contributed to the article and approved the submitted version.

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Kuang, S., Wang, J., Wei, Z. et al. The regulatory function of lncRNA and constructed network in epilepsy. Neurol Sci 44, 1543–1554 (2023). https://doi.org/10.1007/s10072-023-06648-5

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  • DOI: https://doi.org/10.1007/s10072-023-06648-5

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