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Association between sleep disturbances and pain subtypes in Parkinson’s disease

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Abstract

Objective

To explore the influence of sleep disturbances on the various pain subtypes experienced by patients with Parkinson’s disease (PD).

Methods

A cohort of eighty-eight patients with PD-related pain was recruited for this study. Their demographic and clinical features, including age, disease duration, levodopa equivalent daily dose (LEDD), and scores on the Unified Parkinson’s Disease Rating Scale-III (UPDRS III), Hoehn-Yahr Scale (H&Y), Pittsburgh Sleep Quality Index (PSQI), King’s Parkinson’s disease Pain Scale (KPPS), visual analog scale (VAS), Mini-Mental State Examination (MMSE), activities of daily living scale (ADL), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA), were recorded.

Results

The prevalence of sleep disorders was 76.1% in patients with PD-related pain. Among these patients, the group of poor sleep had more severe motor symptoms, more anxiety and depression symptoms, lower functional independence, and experienced more pain, such as musculoskeletal pain, chronic pain, fluctuation related pain, nocturnal pain, and discoloration/edema/swelling (p < 0.05). In addition, PSQI scores correlated positively with the scores of all 7 domains in KPPS (p < 0.05). H&Y stage and PSQI were significant independent variables explaining 50.0% of the variance in KPPS scores.

Conclusions

Sleep disturbance showed an association with pain in PD patients and may have a greater effect on some certain subtypes of PD-related pain than others.

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Data availability

Data will be provided upon reasonable request.

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Acknowledgements

The authors would like to appreciate the patients and their families for their enthusiasm and participation in this study.

Funding

The work was supported by the key research and development plan of science and technology department of Jiangxi Province (NO.20202BBGL73104), science and technology project of Jiangxi provincial health commission (NO.202110017), and science and technology project of Jiangxi administration of traditional Chinese medicine (NO.2020A0310).

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Nanchang University, Yong Wai Zheng Street 17#, Nanchang, 330006, Jiangxi province, China

    Liang Gao, Weiling Huang, Laisheng Cai & Huihua Li

Authors
  1. Liang Gao
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  2. Weiling Huang
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  3. Laisheng Cai
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  4. Huihua Li
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Contributions

GL: study conception and design; data analysis; preparation of first draft and subsequent versions. HW: data acquisition and analysis, review and critique. CL: data acquisition and analysis, review and critique. LH: study conception and design; data analysis; review and critique.

Corresponding authors

Correspondence to Liang Gao or Huihua Li.

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Ethical approval

The study was approved by the ethics committee of the First Affiliated Hospital of Nanchang University (No.2020-9-56).

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All participants gave written informed consent to participate.

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The authors declare no competing interests.

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Gao, L., Huang, W., Cai, L. et al. Association between sleep disturbances and pain subtypes in Parkinson’s disease. Neurol Sci 43, 4785–4790 (2022). https://doi.org/10.1007/s10072-022-06030-x

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