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Does transcranial direct current stimulation enhance cognitive performance in Parkinson’s disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study

  • Clinical Trial article
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Abstract

Background

Parkinson’s disease-mild cognitive impairment (PD-MCI) is garnering attention as a key interventional period for cognitive impairment. Currently, there are no approved treatments for PD-MCI and encouraging results of transcranial direct current stimulation (tDCS) combined with other interventions have been proposed, though the efficacy and neural mechanisms of tDCS alone have not been studied in PD-MCI yet.

Objectives

The present double-blind, randomized, sham-controlled study assessed the effects of tDCS over the dorsolateral prefrontal cortex on cognitive functions via neuropsychological and electrophysiological evaluations in individuals with PD-MCI for the first time.

Method

Twenty-six individuals with PD-MCI were administered 10 sessions of active (n = 13) or sham (n = 13) prefrontal tDCS twice a day, for 5 days. Changes were tested through a comprehensive neuropsychological battery and event-related potential recordings, which were performed before, immediately, and 1 month after the administrations.

Results

Neuropsychological assessment showed an improvement in delayed recall and executive functions in the active group. N1 amplitudes in response to targets in the oddball test-likely indexing attention and discriminability and NoGo N2 amplitudes in the continuous performance test-likely indexing cognitive control and conflict monitoring increased in the active group. Active stimulation elicited higher benefits 1 month after the administrations.

Conclusion

The present findings substantiate the efficacy of tDCS on cognitive control and episodic memory, along with the neural underpinnings of cognitive control, highlighting its potential for therapeutic utility in PD-MCI.

Trial registration.

NCT 04,171,804.

Date of registration: 21/11/2019.

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Data availability

The corresponding author has full access to all data and material and can provide availability if needed.

Code availability

SPSS 25.0.

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Acknowledgements

The authors are grateful to the patients who participated in this study and thank for the support of the Istanbul University, Teaching Staff Training Program (TSTP).

Author information

Authors and Affiliations

  1. Department of Physiology, Graduate School of Health Sciences, Istanbul University, Istanbul, Turkey

    Serkan Aksu & Fatma Aytül Uyar

  2. Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Serkan Aksu, Atilla Uslu & Fatma Aytül Uyar

  3. Department of Physiology, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey

    Serkan Aksu

  4. Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Pınar İşçen, Başar Bilgiç & Haşmet Hanağası

  5. Department of Software Engineering, Faculty of Engineering, Muğla Sıtkı Koçman University, Muğla, Turkey

    Emine Elif Tülay

  6. Department of Psychiatry, Kırklareli Research and Training Hospital, Kırklareli, Turkey

    Huzeyfe Barham

  7. Department of Psychiatry, Ergani State Hospital, Diyarbakır, Turkey

    Ahmet Zihni Soyata

  8. Department of Neurology, School of Medicine, Bahcesehir University, Istanbul, Turkey

    Asli Demirtas-Tatlidede

  9. Private Clinic, Istanbul, Turkey

    Gülsen Babacan Yıldız

  10. Department of Clinical and Health Psychology, Center for Cognitive Aging and Memory, McKnight Brain Institute, Cognitive Aging and Memory Clinical Translational Research Program, University of Florida, Gainesville, USA

    Adam J. Woods

  11. Department of Physiology, School of Medicine, Koç University, Istanbul, Turkey

    Sacit Karamürsel

Authors
  1. Serkan Aksu
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  2. Atilla Uslu
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  3. Pınar İşçen
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  4. Emine Elif Tülay
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  5. Huzeyfe Barham
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  6. Ahmet Zihni Soyata
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  7. Asli Demirtas-Tatlidede
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  8. Gülsen Babacan Yıldız
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  9. Başar Bilgiç
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  10. Haşmet Hanağası
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  11. Adam J. Woods
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  12. Sacit Karamürsel
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  13. Fatma Aytül Uyar
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Corresponding author

Correspondence to Serkan Aksu.

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This study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Aksu, S., Uslu, A., İşçen, P. et al. Does transcranial direct current stimulation enhance cognitive performance in Parkinson’s disease mild cognitive impairment? An event-related potentials and neuropsychological assessment study. Neurol Sci 43, 4029–4044 (2022). https://doi.org/10.1007/s10072-022-06020-z

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  • DOI: https://doi.org/10.1007/s10072-022-06020-z

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