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Impact of dietary polyphenols on neuroinflammation-associated disorders

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Abstract

Neurodegenerative disorders like Alzheimer’s, Parkinson’s, and associated dementia typically originate with altered protein folding and aggregation of their β structures in the neurons. This self-aggregation leads to glial activation in the brain, causing neuroinflammation and leads to neuronal death. According to statistics provided by WHO, there are around 50 million people with dementia worldwide and every year, 10 million more cases are projected to increase. Also, around 5–8 percentage of people who are aged above 60 globally has dementia or associated disorders. Over 82 million in 2030 and 152 in 2050 are expected to have dementia. Most of these patients fall into low–middle-income countries which makes it even more essential to find an affordable and effective treatment method. Polyphenols of different origin are studied for their potential role as anti-neuro-inflammatory molecules. This review would summarize recent advances in three widely researched dietary polyphenols projected as potential therapeutic agents for disorders like Alzheimer’s, Parkinson’s, etc. They are Resveratrol, Catechins, and Tannins. The review would discuss the recent advances and challenges in using these polyphenols using specific examples as potential therapeutic agents against neuroinflammation associated disorders.

Graphical abstract

An abstract of neuroinflammation-associated events and the effects by selected polyphenols.

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Ministry of Human Resources and Development (MHRD), India, funds the first author for her graduate thesis research during the period in which this review article is written. DST-Inspire (DST/INSPIRE/04/2015/000377) and IITH interdisciplinary grant helped the authors with monetary support needed for the purchase of lab equipment like workstations.

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  1. Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, India

    Neeraja Revi

  2. Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, India

    Aravind Kumar Rengan

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The first author (Ms.Neeraja Revi) conceptualized the article, interpreted relevant literature, and drafted the manuscript. The corresponding author (Dr. Aravind Kumar Rengan) revised the article for its rational content and mentored the first author in drafting the manuscript.

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Revi, N., Rengan, A.K. Impact of dietary polyphenols on neuroinflammation-associated disorders. Neurol Sci 42, 3101–3119 (2021). https://doi.org/10.1007/s10072-021-05303-1

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