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Association between subjective autonomic dysfunction and fatigue in Parkinson’s disease in southern Chinese

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Abstract

Study objectives

The aim was to investigate the association between autonomic symptoms and fatigue of Parkinson’s disease (PD) in southern Chinese population.

Methods

In this study, 602 PD patients were recruited. All patients were evaluated by Scales for Outcomes in Parkinson’s Disease-Autonomic questionnaire (SCOPA-AUT), Hamilton anxiety rating scale and Hamilton depression rating scale, non-motor symptoms scale (NMSS), and fatigue severity scale (FSS).

Results

Total score and gastrointestinal subpart, urinary subpart, and cardiovascular subpart of NMSS and SCOPA-AUT were associated with FSS scores (NMSS: total score: p < 0.001; gastrointestinal: p = 0.006; urinary: p = 0.001; cardiovascular: p < 0.001; SCOPA-AUT: total score: p < 0.001; gastrointestinal: p = 0.011; urinary: p < 0.001; cardiovascular: p = 0.003).

Conclusions

Autonomic symptoms were associated with fatigue of PD.

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Abbreviations

CBD:

cerebral-basal degeneration

COMPASS:

Composite Autonomic Symptom Score

FSS:

fatigue severity scale

HARS:

Hamilton anxiety rating scale

HDRS:

Hamilton depression rating scale

MSA:

multiple system atrophy

MDS:

movement disorders society

MIBG:

meta-iodobenzylguanidine

NMSS:

non-motor symptoms scale

PD:

Parkinson’s disease

PSP:

progressive supranuclear palsy

SCOPA-AUT:

Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire

SD:

standard deviation

UPDRS:

Unified Parkinson’s disease rating scale

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Acknowledgements

This work was supported by the Technology Development Project of Suchow (SYS2019006) and the Medicine and Technology Project of Changshu (CSWS201609). We thank all the patients who participated in this study.

Author information

Author notes

  1. Zongbo Zhao and Hui Liu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology and Institute of Neurology, The Affiliated Changshu Hospital of Xuzhou Medical University, Suchow, People’s Republic of China

    Zongbo Zhao, Hui Liu, Jianzhong Xue, Zhige Shi & Nianxing You

Authors
  1. Zongbo Zhao
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  2. Hui Liu
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  3. Jianzhong Xue
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  4. Zhige Shi
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Contributions

Zongbo Zhao and Hui Liu collected the PD and control data, performed the statistical analysis, and drafted the manuscript. Zhige Shi and Jianzhong Xue collected the PD data and designed the study. Nianxing You supervised the study, double-checked the statistical analysis, and revised the manuscript.

Corresponding author

Correspondence to Nianxing You.

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Ethical approval

None declared. All authors have seen and approved the manuscript

Conflict of interest

The authors declare no competing interests.

Informed consent

Written informed consent is obtained for each participant. The study has been approved by the Ethics Committee of The Affiliated Changshu Hospital of Xuzhou Medical University.

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Statement of significance

Autonomic dysfunction is important in the development of PD. We found that the severity of autonomic dysfunction was associated with severity of fatigue in PD in southern Chinese.

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Zhao, Z., Liu, H., Xue, J. et al. Association between subjective autonomic dysfunction and fatigue in Parkinson’s disease in southern Chinese. Neurol Sci 42, 2951–2954 (2021). https://doi.org/10.1007/s10072-021-05209-y

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  • DOI: https://doi.org/10.1007/s10072-021-05209-y

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