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Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study

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Abstract

Objective

To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients.

Method

A longitudinal prospective study was conducted on 30 migraineurs, 30 TTH patients, and 30 age-matched healthy controls. Anxiety and depression were measured by using the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Depression Inventory (BDI). Salivary IL-6, IL-1β, and CRP were collected in distinct time points as A: headache-free period, B: during headache, C: 1 day after headache attack, and measured by using ELISA kits.

Results

No significant differences were found in time variation of CRP, IL-1β, and IL-6 levels between migraine and TTH (p > 0.05). IL1-β had the highest discriminative value (area under the curve = 0.924, p value < 0.001), and then CRP (area under the curve = 0.763, p value < 0.001) and IL-6 (area under the curve = 0.537, p value = 0.58). CRP and IL-6 were negatively correlated with HAM-A and BDI scores.

Conclusion

IL1-β had the highest discriminative value between headache patients and controls compared with CRP and IL-6. CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups.

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Authors and Affiliations

  1. 1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Vassilisis Sophias Avenue 72-74, 115 28, Athens, Greece

    Anastasia Bougea, Nikolaos Spantideas, Petros Galanis, Paraskevi Katsika, Fotini Boufidou, Panagiota Voskou, Ioannis Vamvakaris, Evangelos Anagnostou, Xrysa Nikolaou & Evangelia Kararizou

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  1. Anastasia Bougea
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  2. Nikolaos Spantideas
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  3. Petros Galanis
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  4. Paraskevi Katsika
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  5. Fotini Boufidou
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  6. Panagiota Voskou
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  7. Ioannis Vamvakaris
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  8. Evangelos Anagnostou
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Correspondence to Anastasia Bougea.

Ethics declarations

The study protocol was approved by the Institutional Review Board (IRB) of Aeginition Hospital of Athens (IRB approval number 638/5.11.2015). The procedures were in accordance with the ethical standards with the Helsinki Declaration of 1975, as revised in 2013 and written informed consent was obtained from all patients.

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Bougea, A., Spantideas, N., Galanis, P. et al. Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study. Neurol Sci 41, 877–884 (2020). https://doi.org/10.1007/s10072-019-04151-4

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  • DOI: https://doi.org/10.1007/s10072-019-04151-4

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