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Multiple sclerosis in the Republic of San Marino, Italian peninsula: an incidence and prevalence study from a high-risk area

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Abstract

Epidemiological studies on multiple sclerosis (MS) carried out in Southern Europe in the last years have shown a significant increase in the disease frequency. Previous surveys conducted in the Republic of San Marino, Northern Italian peninsula, identified that the population is at high risk for MS, with a prevalence of 51.6 per 100,000 population in 1982 and of 166.7 in 2005 and with a mean annual incidence of 7.9 per 100,000 for the period 1990–2005. The present work is a community-based intensive prevalence and incidence survey, by a complete enumeration approach, to update the prevalence and incidence of MS in the Republic of San Marino. The mean annual incidence for the period 2005–14 was 7.7 (95% CI 4.9–11.4) per 100,000, 3.3 (95% CI 1.1–7.6) for men and 11.9 (95% CI 7.2–18.6) for women. On 31 December 2014, 67 patients (19 men and 48 women), suffering from definite or probable MS and living in the Republic of San Marino, yielded a crude prevalence of 204.3 (95% CI 158.4–259.5) per 100,000, 117.8 (95% CI 70.9–183.7) for men and 288.2 (95% CI 212.4–383.3) for women. Our study has confirmed San Marino is an area at high risk for MS, in line with epidemiological data from continental Italy. The marked increase in MS prevalence over time in this population can be ascribable to increased survival and improved ascertainment, in the presence of a substantially stable, yet high, incidence rate.

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Acknowledgements

The authors thank Eva Sjolin for her help in revising the translation of the text.

Funding

This work is supported by Ferrara University (Fondo di Ateneo per la Ricerca).

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Authors and Affiliations

  1. Department of Biomedical and Specialty-Surgical Sciences, Section of Neurology, Psychology and Psychiatry, University of Ferrara, Via Aldo Moro 8, 44124, Ferrara, Italy

    Marta Caniglia-Tenaglia, Elisabetta Groppo, Ilaria Casetta, Vittorio Govoni, Mattia Fonderico, Maura Pugliatti & Enrico Granieri

  2. Unit of Neurology, State Hospital, Cailungo, Republic of San Marino

    Susanna Guttmann, Chiara Monaldini, Dario Manzaroli, Mirco Volpini & Maurizio Stumpo

Authors
  1. Marta Caniglia-Tenaglia
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  2. Susanna Guttmann
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  3. Chiara Monaldini
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  4. Dario Manzaroli
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  5. Mirco Volpini
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  8. Ilaria Casetta
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  11. Maura Pugliatti
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  12. Enrico Granieri
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Correspondence to Enrico Granieri.

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Caniglia-Tenaglia, M., Guttmann, S., Monaldini, C. et al. Multiple sclerosis in the Republic of San Marino, Italian peninsula: an incidence and prevalence study from a high-risk area. Neurol Sci 39, 1231–1236 (2018). https://doi.org/10.1007/s10072-018-3402-6

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  • DOI: https://doi.org/10.1007/s10072-018-3402-6

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