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Affective symptoms and determinants of health-related quality of life in Mexican people with epilepsy

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Abstract

Epilepsy is known to be associated with multiple psychiatric comorbidities, such as depression, sleep-disorders, and anxiety. The objective of this study was to determine the prevalence and impact of affective symptoms over health-related quality of life (QOL) in Mexican people with epilepsy (PWE). We performed a cross-sectional observational study on 73 consecutive PWE and corresponding age- and sex-matched controls. HrQOL was assessed using the QOLIE-10 (QOL in Epilepsy-10) instrument. Clinical and demographic characteristics were recorded, and instruments evaluating depressive/anxiety symptoms, sleep quality, and insomnia were completed. PWE had more depressive/anxiety symptoms when compared with controls. QOLIE-10 scores were significantly inversely correlated with poor sleep quality, insomnia symptoms, depressive/anxiety symptoms, and number of anti-epileptic drugs used, but not with seizure type or number of seizures per month. A poor QOL was independently associated only with anti-epileptic drug polytherapy. PWE are burdened with depressive/anxiety symptoms at alarming rates. The presence of depressive symptoms along with sleep disturbances and more significantly, anti-epileptic drug polytherapy, appears to negatively impact QOL, to a greater degree than short-term seizure control.

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Authors and Affiliations

  1. Neurology Service, University Hospital “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64700, Monterrey, NL, México

    Carlos R. Camara-Lemarroy & Marco A. Díaz-Torres

  2. Department of Psychiatry, University Hospital “Dr. José E. González”, Universidad Autónoma de Nuevo León, Monterrey, México

    Mariana Hoyos, Beatriz E. Ibarra-Yruegas & Rolando De León

Authors
  1. Carlos R. Camara-Lemarroy
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  2. Mariana Hoyos
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  3. Beatriz E. Ibarra-Yruegas
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  4. Marco A. Díaz-Torres
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  5. Rolando De León
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Correspondence to Carlos R. Camara-Lemarroy.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study protocol was approved by the ethics committee of the University Hospital and the Autonomous University of Nuevo Leon.

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Informed consent was obtained from all individual participants included in the study.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Camara-Lemarroy, C.R., Hoyos, M., Ibarra-Yruegas, B.E. et al. Affective symptoms and determinants of health-related quality of life in Mexican people with epilepsy. Neurol Sci 38, 1829–1834 (2017). https://doi.org/10.1007/s10072-017-3075-6

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  • DOI: https://doi.org/10.1007/s10072-017-3075-6

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