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A novel oxidative stress marker in migraine patients: dynamic thiol–disulphide homeostasis

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An Erratum to this article was published on 31 May 2016

Abstract

The aim of this study was to investigate dynamic thiol–disulphide homeostasis as a novel oxidative stress parameter in migraine patients. A total of 115 participants were included in the study, and 63 of whom were diagnosed with migraine. The total thiol (–SH+–S-S–) and native thiol (–SH) levels in the serum were measured in all patients and healthy individuals. The dynamic disulphide bond (–S-S–) and (–S-S–) × 100/(–SH), (–S-S–) × 100/(–SH+–S-S–), and –SH × 100/(–SH+–S-S–) ratios were calculated from these values. The total and native thiol levels of migraine patients participating in the study were found to be significantly higher than the total and native thiol levels of healthy individuals. No statistically significant difference was determined in terms of the dynamic disulphide bond amounts or (–S-S–) × 100/(–SH), (–S-S–) × 100/(–SH+–S-S–), and –SH × 100/(–SH+–S-S–) ratios. The total thiol, native thiol, and dynamic disulphide bond levels, and (–S-S–) × 100/(–SH), (–S-S–) × 100/(–SH+–S-S–), and –SH × 100/(–SH+–S-S–) ratios were not correlated with attack frequency, pain intensity, or migraine type. Oxidative stress is considered to be one of the molecular changes underlying the pathogenesis of migraine.

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Acknowledgments

The biochemical analysis of this study was performed at the biochemistry lab of Ataturk Education and Research Hospital. The authors would like to thank Ozcan Erel’s research assistants for their invaluable assistance. The authors also would like to acknowledge: Meliz Vural for her professional translation and Elsevier Language Editing Service for their Professional Editing. The statistical evaluation of this study is made by Yildirim Beyazıt University Statistical Consultancy Application and Research Centre.

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Authors and Affiliations

  1. Department of Neurology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

    Sadiye Gumusyayla, Gonul Vural & Orhan Deniz

  2. Department of Neurology, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

    Hesna Bektas

  3. Department of Biochemistry, Ankara Ataturk Education and Research Hospital, Ankara, Turkey

    Salim Neselioglu

  4. Department of Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

    Ozcan Erel

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  1. Sadiye Gumusyayla
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Correspondence to Sadiye Gumusyayla.

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Gumusyayla, S., Vural, G., Bektas, H. et al. A novel oxidative stress marker in migraine patients: dynamic thiol–disulphide homeostasis. Neurol Sci 37, 1311–1317 (2016). https://doi.org/10.1007/s10072-016-2592-z

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  • DOI: https://doi.org/10.1007/s10072-016-2592-z

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