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Role of neurostimulation in migraine

  • NEWS ON TREATMENT OF PRIMARY HEADACHES AND NEUROSTIMULATION
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Abstract

Chronic forms of headache characterized by daily or almost daily headache, affect almost 3 % of general population. They represent the most disabling forms of headache inducing high degree of disability, poor quality of life for patients. During the last decades, several neuromodulatory surgical techniques have been developed for the management of headaches that are unresponsive to medical treatment. Invasive and non invasive central and/or peripheral neurostimulation techniques have been developed by different research groups with encouraging results for different type of headaches. In this report, the acute effect of non invasive vagus nerve stimulation (nVNS) (gammacore) was evaluated to treat migraine attacks in a population of patients affected by high-frequency episodic migraine or chronic migraine. The aim of this study was to verify the efficacy of nVNS to treat migraine attacks in this specific category of patients.

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References

  1. Bigal ME, Lipton RB (2009) Overuse of acute migraine medications and migraine chronification. Curr Pain Headache Rep 13(4):301–307

    Article  PubMed  Google Scholar 

  2. Headache Classification Committee of the International Headache Society (HIS) (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33:629–808

    Article  Google Scholar 

  3. Magis D, Schoenen J (2012) Advances and challenges in neurostimulation for headaches. Lancet Neurol 11(8):708–719

    Article  PubMed  Google Scholar 

  4. Leone M, Franzini A, Proietti Cecchini A, Mea E, Broggi C, Bussone G (2009) Costs of hypothalamic stimulatin in chronic drug-resistant cluster headache: preliminary data. Neurol Sci 30(Suppl 1):S43–S47

    Article  PubMed  Google Scholar 

  5. Jürgens TP, Leone M (2013) Pearls and pitfalls: neurostimulation in headache. Cephalalgia 33(8):512–525

    Article  PubMed  Google Scholar 

  6. Magis D, Jensen R, Schoenen J (2012) Neurostimulation therapies for primary headache disorders: present and future. Current Opin Neurol 25:269–276

    Article  CAS  Google Scholar 

  7. Da Silva A, Mendonca M, Zaghi S, Lopes M, Dos Santos MF, Spierings E, Bajwa Z, Datta A, Bikson M, Fregni F (2012) tDCS-induced analgesia and electrical foelds in pain-related neural networks in chronic migraine. Headache 52:1283–1295

    Article  Google Scholar 

  8. Connor DE Jr, Nixon M, Nanda A, Guthikonda B (2012) Vagal nerve stimulation for the treatment of medically refractory epilepsy: a review of the current literature. Neurosurg Focus 32(3):E12

    Article  PubMed  Google Scholar 

  9. Grimm S, Bajbouj M (2010) Efficacy of vagus nerve stimulation in the treatment of depression. Expert Rev Neurother 10(1):87–92

    Article  CAS  PubMed  Google Scholar 

  10. Proietti Cecchini A, Mea E, Tullo V, Curone M, Franzini A, Broggi G, Savino M, Bussone G, Leone M (2009) Vagus nerve stimulation in drug-resistant daily chronic migraine with depression: preliminary data. Neuol Sci 30(Suppl 1):S101–S104

    Google Scholar 

  11. Mauskop A (2005) Vagus nerve stimulation relieves chronic refractory migraine and cluster headaches. Cephalalgia 25(2):82–86

    Article  CAS  PubMed  Google Scholar 

  12. Ko D, Heck C, Grafton S, Apuzzo MLJ et al (1996) Vagus nerve stimulation activates central nervous system structures in epileptic patients during PET H 152 O blood flow imaging. Neurosurgery 39:426–431

    Article  CAS  PubMed  Google Scholar 

  13. Henry TR, Votaw JR, Pennell PB, Epstein CM, Bakay RAE, Faber TL et al (1997) Acute vagus nerve stimulation selectively alters blood flow in somatosensory and limbic cortex and the cerebellum of patients with complex partial seizures. Epilepsia 38(Suppl 8):144

    Google Scholar 

  14. Multon S, Schoenen J (2005) Pain control by vagus nerve stimulation: from animal to man…and back. Acta Neurol Belg 105(2):62–67

    PubMed  Google Scholar 

  15. Lyubashina OA, Sokolov AY, Panteleev SS (2012) Vagal afferent modulation of spinal trigeminal neuronal responses to dural electrical stimulation in rats. Neuroscience 222:29–37

    Article  CAS  PubMed  Google Scholar 

  16. Oshinsky ML, Murphy AL, Hekierski H Jr, Cooper M, Simon BJ (2014) Non invasive vagus nerve stimulation as treatment for trigeminal allodynia. Pain 155(5):1037–1042

    Article  PubMed Central  PubMed  Google Scholar 

  17. Goadsby PJ, Grosberg BM, Mauskop A, Cady R, Simmons KA (2014) Effect of noninvasive vagus nerve stimulation on acute migraine: an open-label pilot study. Cephalalgia 34(12):986–993

    Article  CAS  PubMed  Google Scholar 

  18. Proietti A, Grazzi L (2014) Emerging therapies for chronic migraine. Curr Pain Headache Rep 18(408):1–6

    Google Scholar 

  19. Diener HC, Bingel U (2014) Surgical treatment for migraine: time to fight against the knife. Cephalalgia. doi:10.1177/0333102414545895

    Google Scholar 

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Correspondence to L. Grazzi.

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Grazzi, L., Padovan, A. & Barbanti, P. Role of neurostimulation in migraine. Neurol Sci 36 (Suppl 1), 121–123 (2015). https://doi.org/10.1007/s10072-015-2176-3

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  • DOI: https://doi.org/10.1007/s10072-015-2176-3

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