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Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives

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Abstract

The diverse populations reportedly suffer from obesity on a global scale, and inconclusive evidence has indicated that both environmental and genetic factors are associated with obesity development. Therefore, a need exists to examine potential therapeutic or prophylactic molecules for obesity treatment. Prebiotics with non-digestible oligosaccharides (NDOs) have the potential to treat obesity. A limited number of prebiotic NDOs have demonstrated their ability as a convincing therapeutic solution to encounter obesity through various mechanisms, viz., stimulating beneficial microorganisms, reducing the population of pathogenic microorganisms, and also improving lipid metabolism and glucose homeostasis. NDOs include pectic-oligosaccharides, fructo-oligosaccharides, xylo-oligosaccharides, isomalto-oligosaccharides, manno-oligosaccharides and other oligosaccharides which significantly influence the overall human health by different mechanisms. This review provides the treatment of obesity benefits by incorporating these prebiotic NDOs, according to established scientific research, which shows their good effects extend beyond the colon.

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Acknowledgements

DG greatly appreciates the support provided by the Management and the Principal of M S Ramaiah Institute of Technology, Bangalore, India, while writing the manuscript.

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No funding was obtained for this study.

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Authors and Affiliations

  1. Department of Biotechnology, M S Ramaiah Institute of Technology, Bengaluru, 560 054, India

    G. Divyashri, T. P. Krishna Murthy & Dey Priyadarshini

  2. Department of Food Technology, Faculty of Engineering, Karpagam Academy of Higher Education, Coimbatore, 641 021, India

    Pothiyappan Karthik

  3. School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, NSW, 2006, Australia

    Kakarla Raghava Reddy

  4. Faculty of Allied Health Sciences, BLDE (Deemed-to-Be University), Vijayapura, 586103, Karnataka, India

    Anjanapura V. Raghu

  5. Department of Biotechnology, School of Bioengineering, Integrated Bioprocessing Laboratory, SRM Institute of Science and Technology (SRM IST), 603 203, Kattankulathur, India

    Vinoth Kumar Vaidyanathan

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  1. G. Divyashri
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  2. Pothiyappan Karthik
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  3. T. P. Krishna Murthy
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  4. Dey Priyadarshini
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  5. Kakarla Raghava Reddy
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  6. Anjanapura V. Raghu
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  7. Vinoth Kumar Vaidyanathan
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Contributions

GD prepared original draft, performed visualization and investigation. KRR conceived and designed the analysis, methodology and conceptualization. AVR and VVK contributed to the final version of the manuscript by editing and supervision. All authors read and approved the final manuscript.

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Correspondence to G. Divyashri or Vinoth Kumar Vaidyanathan.

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Divyashri, G., Karthik, P., Murthy, T.P.K. et al. Non-digestible oligosaccharides-based prebiotics to ameliorate obesity: Overview of experimental evidence and future perspectives. Food Sci Biotechnol 32, 1993–2011 (2023). https://doi.org/10.1007/s10068-023-01381-3

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