Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease occurring in the gut causing chronic diarrhea and abdominal pain with severe complications. Sesame cake is a by-product of sesame oil production, possessing various beneficial properties; however, little is known about the effect of sesame cake extract (SCE) against IBD. The aim of this study was to investigate the protective effect of SCE against dextran sulfate sodium (DSS)-induced colitis in mice. Administration of SCE was first performed at 7 days before treating mice with 2.5% DSS to induce colitis for 7 days. SCE pretreatment improved symptoms of DSS-induced colitis. In addition, SCE ameliorated histopathological damages of the mucus layer in colon tissues and decreased pro-inflammatory cytokines in colitis-induced mice. SCE also suppressed apoptosis and oxidative stress in colitis-induced colon tissues. Together, these findings suggest that SCE could be potential nutraceuticals for treating colitis.
Similar content being viewed by others
References
Adlercreutz H. Lignans and human health. Critical Reviews in Clinical Laboratory Sciences. 44: 483-525 (2007)
Bankole E, Read E, Curtis MA, Neves JF, Garnett JA. The relationship between mucins and ulcerative colitis: A Systematic Review. Journal of Clinical Medicine. 10: 1935 (2021)
Ben Othman S, Katsuno N, Kanamaru Y, Yabe T. Water-soluble extracts from defatted sesame seed flour show antioxidant activity in vitro. Food Chemistry. 175: 306-314 (2015)
Bourgonje AR, Feelisch M, Faber KN, Pasch A, Dijkstra G, van Goor H. Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease. Trends in Molecular Medicine. 26: 1034-1046 (2020)
Chang SH, Jang J, Oh S, Yoon JH, Jo DG, Yun UJ, Park KW. Nrf2 induces Ucp1 expression in adipocytes in response to beta3-AR stimulation and enhances oxygen consumption in high-fat diet-fed obese mice. BMB Reports. 54: 419-424 (2021)
Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar M. Dextran sulfate sodium (DSS)-induced colitis in mice.Vol. 104 In:Current protocols in immunology. John Wiley & Sons, Inc., Danvers, MA, USA pp. 15.25.1–15.25.14. (2014)
Chen PR, Chien KL, Su TC, Chang CJ, Liu TL, Cheng HC, Tsai CM. Dietary sesame reduces serum cholesterol and enhances antioxidant capacity in hypercholesterolemia. Nutrition Research. 25: 559-567 (2005)
Chung BH, Lee JJ, Kim JD, Jeong D, Lee H, Choe J, Ha KS, Kwon YG, Kim YM. Angiogenic activity of sesamin through the activation of multiple signal pathways. Biochemical and Biophysical Research Communications. 391: 254-260 (2010)
Dalibalta S, Majdalawieh AF, Manjikian H. Health benefits of sesamin on cardiovascular disease and its associated risk factors. Saudi Pharmaceutical Journal. 28: 1276-1289 (2020)
Duan L, Cheng S, Li L, Liu Y, Wang D, Liu G. Natural anti-inflammatory compounds as drug candidates for Inflammatory bowel disease. Frontiers in Pharmacology. 12: 684486 (2021)
Durazzo A, Lucarini M, Camilli E, Marconi S, Gabrielli P, Lisciani S, Gambelli L, Aguzzi A, Novellino E, Santini A, Turrini A, Marletta L. Dietary lignans: definition, description and research trends in databases development. Molecules. 23: 2251 (2018)
Edelblum KL, Yan F, Yamaoka T, Polk DB. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflammatory Bowel Diseases. 12: 413-424 (2006)
Elleuch M, Besbes S, Roiseux O, Blecker C, Attia H. Quality characteristics of sesame seeds and by-products. Food Chemistry. 103: 641-650 (2007)
Eom SJ, Zu HD, Lee J, Kang MC, Park J, Song KM, Lee NH. Development of an ultrasonic system for industrial extraction of unheated sesame oil cake. Food Chemistry. 354: 129582 (2021)
Esmaeilzadeh Kenari R, Mohsenzadeh F, Amiri ZR. Antioxidant activity and total phenolic compounds of Dezful sesame cake extracts obtained by classical and ultrasound-assisted extraction methods. Food Science & Nutrition. 2: 426-435 (2014)
Gao W, Wang C, Yu L, Sheng T, Wu Z, Lin Y, Gong Y. Chlorogenic acid attenuates dextran dodium sulfate-induced ulcerative colitis in mice through MAPK/ERK/JNK pathway. BioMed Research International. 2019: 679789 (2019)
Griffiths AM. Inflammatory bowel disease. Nutrition. 14: 788-791 (1998)
Gupta M, Mishra V, Gulati M, Kapoor B, Kaur A, Gupta R, Tambuwala MM. Natural compounds as safe therapeutic options for ulcerative colitis. Inflammopharmacology. 30: 397-434 (2022)
Hsu E, Parthasarathy S. Anti-inflammatory and antioxidant effects of sesame oil on atherosclerosis: A descriptive literature review. Cureus. 9: e1438 (2017)
Hu Y, Li Y, Sampson L, Wang M, Manson JE, Rimm E, Sun Q. Lignan intake and risk of coronary heart disease. Journal of the American College of Cardiology. 78: 666-678 (2021)
Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes & Development. 27: 2179-2191 (2013)
Jung SJ, Jung ES, Ha KC, Baek HI, Park YK, Han SK, Chae SW, Lee SO, Chung YC. Efficacy and safety of sesame oil cake extract on memory function improvement: A 12-Week, randomized, double-blind, placebo-controlled pilot study. Nutrients. 13: 2606 (2021)
Kaser A, Zeissig S, Blumberg RS. Inflammatory bowel disease. Annual Review of Immunology. 28: 573-621 (2010)
Khor TO, Huang MT, Prawan A, Liu Y, Hao X, Yu S, Cheung WK, Chan JY, Reddy BS, Yang CS, Kong AN. Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer. Cancer Prevention Research. 1: 187-191 (2008)
Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 474: 307-317 (2011)
Kim J, Cha YN, Surh YJ. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutation Research. 1-2: 12-23 (2010)
Liu H, Johnston LJ, Wang F, Ma X. Triggers for the Nrf2/ARE signaling pathway and its nutritional regulation: Potential therapeutic applications of ulcerative colitis. International Journal of Molecular Sciences. 22: 11411 (2021)
Liu C, Zeng Y, Wen Y, Huang X, Liu Y. Natural products modulate cell apoptosis: A promising way for the treatment of ulcerative colitis. Frontiers in Pharmacology. 13: 806148 (2022)
Mekky RH, Abdel-Sattar E, Segura-Carretero A, Contreras MDM. Phenolic compounds from sesame cake and antioxidant activity: A new insight for agri-food residues' significance for sustainable development. Foods. 8: 432 (2019)
Mitsuishi Y, Motohashi H, Yamamoto M. The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Frontiers in Oncology. 2: 200 (2012)
Morris JB, Wang ML, Tonnis BD. Variability for oil, protein, lignan, tocopherol, and fatty acid concentrations in eight sesame (Sesamum indicum L.) genotypes. Industrial Crops and Products. 164: 113355 (2021)
Neurath MF. Cytokines in inflammatory bowel disease. Nature Reviews Immunology. 14: 329-342. (2014)
Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. International Journal of Cancer. 121: 1883-1891 (2007)
Ramachandran A, Madesh M, Balasubramanian KA. Apoptosis in the intestinal epithelium: its relevance in normal and pathophysiological conditions. Journal of Gastroenterology and Hepatology. 15: 109-120 (2000)
Rodriguez-Garcia C, Sanchez-Quesada C, Toledo E, Delgado-Rodriguez M, Gaforio JJ. Naturally lignan-rich foods: A dietary tool for health promotion? Molecules. 24: 917 (2019)
Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World Journal of Gastroenterology. 14: 4280-4288 (2008)
Schieber M, Chandel NS. ROS function in redox signaling and oxidative stress. Current Biology. 24: R453-R462 (2014)
Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 140: 1756-1767 (2011)
Sturniolo GC, Mestriner C, Lecis PE, D'Odorico A, Venturi C, Irato P, Cecchetto A, Tropea A, Longo G, D'Inca R. Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scandinavian Journal of Gastroenterology. 33: 644-649 (1998)
Tian T, Wang Z, Zhang J. Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies. Oxidative Medicine and Cellular Longevity. 2017: 4535194 (2017)
Um MY, Choi WH, Ahn JY, Kim S, Kim MK, Ha TY. Sesaminol glucosides improve cognitive deficits and oxidative stress in SAMP8 mice. Food Science and Biotechnology. 18: 1311-1315 (2009)
Verstockt B, Ferrante M, Vermeire S, Van Assche G. New treatment options for inflammatory bowel diseases. Journal of Gastroenterology. 53: 585-590 (2018)
Wan F, Cai XY, Wang MY, Chen L, Zhong RQ, Liu L, Yi B, Hou FJ, Zhang HF. Chlorogenic acid supplementation alleviates dextran sulfate sodium (DSS)-induced colitis via inhibiting inflammatory responses and oxidative stress, improving gut barrier integrity and Nrf-2/HO-1 pathway. Journal of Functional Foods. 87: 104808 (2021)
Wang Y, Wang H, Qian C, Tang J, Zhou W, Liu X, You Q, Hu R. 3-(2-Oxo-2-phenylethylidene)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one (compound 1), a novel potent Nrf2/ARE inducer, protects against DSS-induced colitis via inhibiting NLRP3 inflammasome. Biochemical Pharmacology. 101: 71-86 (2016)
Wang JS, Tsai PH, Tseng KF, Chen FY, Yang WC, Shen MY. Sesamol ameliorates renal injury-mediated atherosclerosis via inhibition of oxidative stress/IKKalpha/p53. Antioxidants. 10: 1519 (2021)
Xu D, Chen L, Chen X, Wen Y, Yu C, Yao J, Wu H, Wang X, Xia Q, Kong X. The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy. Cell Death & Disease. 8: e2983 (2017)
Zhang Y, Guan L, Wang X, Wen T, Xing J, Zhao J. Protection of chlorophyllin against oxidative damage by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. Free Radical Research. 42: 362-371 (2008)
Acknowledgements
D.K.Y. was funded by the Ministry of Science and Technology, Republic of Korea (NRF- 2021R1I1A1A01054531). K.W.P. was funded by the Ministry of Science and Technology, Republic of Korea (NRF-2020R1A2B5B02001592).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Conflict of interest
J.Y.P. has ownership interest in Queensbucket company. The other authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Tungalag, T., Park, J.Y., Park, K.W. et al. Sesame cake extract attenuates dextran sulfate sodium-induced colitis through inhibition of oxidative stress in mice. Food Sci Biotechnol 33, 699–709 (2024). https://doi.org/10.1007/s10068-023-01367-1
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10068-023-01367-1