Abstract
A method to determine methanol (MeOH) and isopropyl alcohol (IPA) was developed using static headspace sampling (HSS) with gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The optimized HSS-GC and HSS-GC/MS methods were validated according to the parameters. The limit of quantification (LOQ) values for MeOH analyzed by HSS-GC/MS and HSS-GC were 0.50–0.56 and 1.97 mg/L, and the corresponding values for IPA were 0.14–0.21 and 1.51 mg/L, respectively. Recoveries were determined by spiking sample matrices, such as vinegar and tea. MeOH and IPA showed excellent recoveries of 93.80–107.60% and 93.92–104.32% with corresponding precisions of 0.51–7.38% and 0.90–7.70%, respectively. Compared to solid-phase microextraction-GC/MS and HSS-GC, the HSS-GC/MS method showed outstanding values for limit of detection and LOQ with improved precision and accuracy. This HSS-GC/MS method was successfully used to monitor residual solvents in 100 food and functional food products.
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This research was supported by a grant (14162food008) from the Ministry of Food and Drug Safety in 2015.
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Lim, H.Y., Ka, MH., Chang, N.I. et al. Development of an analytical method to determine methyl alcohol and isopropyl alcohol in food using static headspace gas chromatography. Food Sci Biotechnol 33, 389–397 (2024). https://doi.org/10.1007/s10068-023-01356-4
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DOI: https://doi.org/10.1007/s10068-023-01356-4