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An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder

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Abstract

Currently, gut microbiota living in the gastrointestinal tract, plays an important role in regulating host’s sleep and circadian rhythms. As a tool, gut microbiota has great potential for treating circadian disturbance and circadian insomnia. However, the relationship between gut microbiota and circadian rhythms is still unclear, and the mechanism of action has still been the focus of microbiome research. Therefore, this article summarizes the current evidences associating gut microbiota with factors that impact host circadian rhythms neurology sleep disorder. Moreover, we discuss the changes to these systems in sleep disorder and the potential mechanism of intestinal microbiota in regulating circadian rhythms neurology sleep disorder via microbial metabolites. Meanwhile, based on the role of intestinal flora, it is provided a novel insight into circadian related insomnia and will be benefit the dietary treatment of circadian disturbance and the circadian related insomnia.

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Acknowledgements

This work was sponsored by the Ningbo Natural Science Foundation (2019A610433).

Funding

Natural Science Foundation of Ningbo Municipality (Grant No. 2019A610433).

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Authors and Affiliations

  1. Department of Food Science and Engineering, Ningbo University, 818 Fenghua Road, Ningbo, 315211, People’s Republic of China

    Yufei Tian, Wei Yang, Gang Chen, Chuanlong Men, Yifan Gu, Xiaoran Song, Ruilin Zhang & Xin Zhang

  2. Department of Clinical Pharmacy, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People’s Republic of China

    Laiyou Wang

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  1. Yufei Tian
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  3. Gang Chen
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Tian, Y., Yang, W., Chen, G. et al. An important link between the gut microbiota and the circadian rhythm: imply for treatments of circadian rhythm sleep disorder. Food Sci Biotechnol 31, 155–164 (2022). https://doi.org/10.1007/s10068-021-01015-6

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