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Comparative evaluation of free radical scavenging activities and cytotoxicity of various solvent fractions of Sandong Sageretia thea (Osbeck) M.C. Johnst. branches

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Abstract

Sageretia thea (Osbeck) M.C.Johnst., an evergreen tender shrub of the Rhamnaceae, has been used as folk medicine and in traditional tea. To the best of our knowledge, this is the first study that investigates the free radical scavenging activity and cell cytotoxicity of S. thea branches. The ethyl acetate fraction and n-butanol fraction were identified to be rich in phenolic compounds exhibiting impressive antioxidant activity after stepwise partitioning of solvent fractions of the methanol extracts of S. thea branches (MB). Among the different human cancer cells tested, maximum cytotoxicity was found in MDA-MB-231 human breast cancer cells with MB, chloroform, ethyl acetate, n-butanol and water fraction. A significant (p<0.05) correlation between antioxidant activities and cytotoxicity exists in each fraction. These results suggest the branches of S. thea can be a valuable source of antioxidants, and they can serve as natural anticancer constituents in nutraceutical and pharmaceutical applications.

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Authors and Affiliations

  1. Faculty of Biotechnology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, 63243, Korea

    Gyeong-A Ko & Somi Kim Cho

  2. School of Biomaterials Science and Technology, College of Applied Life Sciences, SARI, Jeju National University, Jeju, 63243, Korea

    Moa Son & Somi Kim Cho

  3. Subtropical Tropical Organism Gene Bank, Jeju National University, Jeju, 63243, Korea

    Somi Kim Cho

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  1. Gyeong-A Ko
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  2. Moa Son
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  3. Somi Kim Cho
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Correspondence to Somi Kim Cho.

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Ko, GA., Son, M. & Cho, S.K. Comparative evaluation of free radical scavenging activities and cytotoxicity of various solvent fractions of Sandong Sageretia thea (Osbeck) M.C. Johnst. branches. Food Sci Biotechnol 25, 1683–1691 (2016). https://doi.org/10.1007/s10068-016-0259-4

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  • DOI: https://doi.org/10.1007/s10068-016-0259-4

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