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Red bean extracts protect rats against intestinal inflammatory damage

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Abstract

Red beans comprise part of the diet in Korean culture. Anti-inflammatory and anti-septic activities of the butanol fraction of red bean ethanol extracts (BF-RBEE) are known. The intestinal antiinflammatory activity of BF-RBEE and related mechanisms were studied using a rat model of acetic acid-induced colitis. Oral treatment with BF-RBEE (100 mg/kg of body weight) suppressed body weight loss and intestinal inflammatory damage in colitic rats. BF-RBEE treatment reduced the myeloperoxidase activity and the malondialdehyde level that were increased in colitic rats, and restored the reduced level of glutathione. BF-RBEE also inhibited acetic acid-mediated increases in mRNA levels of nitric oxide synthase, interleukin-1β, and tumor necrosis factor-α. Similarly, treatment with 1mg/kg of prednisolone protected rats against intestinal colitic damage with corresponding decreases in levels of these inflammatory indicators. Red beans can be useful for treatment of intestinal inflammatory diseases.

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Authors and Affiliations

  1. Research Center of Bioactive Materials, Institute of Oral Biosciences and School of Dentistry, Chonbuk National University, Jeonju, Jeonbuk, 54896, Korea

    Jeong-Chae Lee

  2. Grassland and Forage Division, National Institute of Animal Science, Rural Development Administration, Cheonan, Chungnam, 31002, Korea

    Ki-Choon Choi

  3. Department of Pharmaceutical Engineering, Konyang University, Nonsan, Chungnam, 32992, Korea

    Seong-Wan Cho

Authors
  1. Ki-Choon Choi
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  2. Seong-Wan Cho
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Correspondence to Jeong-Chae Lee.

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Choi, KC., Cho, SW. & Lee, JC. Red bean extracts protect rats against intestinal inflammatory damage. Food Sci Biotechnol 25, 349–353 (2016). https://doi.org/10.1007/s10068-016-0049-z

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