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Evaluation of Synurus deltoides for antioxidant, antimicrobial, and anti-proliferative activities using In vitro assays

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Abstract

The antioxidant, antimicrobial, and anti-proliferative activities of water and ethanol extracts from leaves of Synurus deltoides (SD) were investigated. Extracts showed strong reductive powers, nitrite-scavenging activities, DPPH, ABTS, hydroxyl, and superoxide radical scavenging activities, and DNA damage prevention activities. SD extracts also showed strong cellular antioxidant activities in a dose-dependent manner with IC50 values of 0.93 and 0.65 mg/mL for water and ethanol extracts, respectively. Antimicrobial activities were evaluated against 4 microorganisms. SD extracts showed high inhibitory activities against Pseudomonas aeruginosa and Staphylococcus aureus. The anti-proliferative activity was dose-dependent against human colon adenocarcinoma (HT-29) and mouse rectum carcinoma cells (CMT-93). In addition, HPLC analyses of SD leaf extracts revealed the presence of different phenolic compounds. SD can be considered as a source of functional foods and pharmaceuticals.

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Authors and Affiliations

  1. Department of Applied Biochemistry, College of Biomedical & Health Science, Konkuk University, Chungju, Chungbuk, 380-701, Korea

    Md. Abul Hasnat, Mehnaz Pervin, Yong Chang Jang, Ji Hong Lim & Beong Ou Lim

  2. Department of Herbal Crop Research, NIHHS, RDA, Eumseong, Chungbuk, 369-873, Korea

    Young Ock Kim

  3. Department of Life Science, College of Biomedical & Health Science, Konkuk University, Chungju, Chungbuk, 380-701, Korea

    Soojin Park

  4. Department of Rehabilitation Medicine, Konkuk University Chungju Hospital, Chungju, Chungbuk, 380-701, Korea

    Jong Moon Kim

Authors
  1. Md. Abul Hasnat
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  4. Young Ock Kim
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  7. Ji Hong Lim
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  8. Beong Ou Lim
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Correspondence to Beong Ou Lim.

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Hasnat, M.A., Pervin, M., Jang, Y.C. et al. Evaluation of Synurus deltoides for antioxidant, antimicrobial, and anti-proliferative activities using In vitro assays. Food Sci Biotechnol 23, 1987–1996 (2014). https://doi.org/10.1007/s10068-014-0271-5

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  • DOI: https://doi.org/10.1007/s10068-014-0271-5

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