Abstract
Sprouting of peanut usually promotes de novo biosynthesis of phenolic compounds such as resveratrol. As phenolic compounds have been reported to possess anti-obesity activity, we investigated the effect of peanut sprout extract (PSE) on weight gain induced by high-fat diet (HF) in C57BL/6J mice. Administration of PSE effectively suppressed the body weight gain induced by HF without altering food intake. Furthermore, blood parameters, including levels of TG and total cholesterol, were significantly improved by administration of 0.5 g/kg BW of PSE compared to mice fed HF alone. Although its mechanism of action remains unclear, the anti-obesity activity of PSE appears to be associated with its inhibition of carbohydrate digestion enzymes, as it dose-dependently inhibited the activities of α-amylase and α-glucosidase but not pancreatic lipase while PSE did not have any inhibitory effect against lipid accumulation in differentiated 3T3L1 adipocyte. In conclusion, PSE deserves further study as a health functional ingredient for body weight control.
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References
Kopelman PG. Obesity as a medical problem. Nature 404: 635–643 (2000)
Gonzalez-Castejon M, Rodriguez-Casado A. Dietary phytochemicals and their potential effects on obesity: A review. Pharmacol. Res. 64: 438–455 (2011)
Cho S, Choi Y, Park S, Park T. Carvacrol prevents diet-induced obesity by modulating gene expressions involved in adipogenesis and inflammation in mice fed with high-fat diet. J. Nutr. Biochem. 23: 192–201 (2012)
Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring). 18: 780–787 (2010).
Rayalam S, Della-Fera MA, Baile CA. Synergism between resveratrol and other phytochemicals: Implications for obesity and osteoporosis. Mol. Nutr. Food Res. 55: 1177–1185 (2011)
Smoliga JM, Baur JA, Hausenblas HA. Resveratrol and health—a comprehensive review of human clinical trials. Mol. Nutr. Food Res. 55: 1129–1141 (2011)
Sanders TH, McMichael Jr RW, Hendrix KW. Occurrence of resveratrol in edible peanuts. J. Agr. Food Chem. 48: 1243–1246 (2000)
Seo JY, Kim HJ, Kim SS, Liu K-H, Lee H-Y, Kim J-S. Laxative effect of peanut sprout extract. Nutr. Res. Pract. 7: 262–266 (2013)
Kim JS, Kwon CS, Son KH. Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid. Biosci. Biotech. Bioch. 64: 2458–2461 (2000)
Kwon CS, Sohn HY, Kim SH, Kim JH, Son KH, Lee JS, Lim JK, Kim JS. Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents. Biosci. Biotech. Bioch. 67: 1451–1456 (2003)
Hwang JT, Park IJ, Shin JI, Lee YK, Lee SK, Baik HW, Ha J, Park OJ. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem. Bioph. Res. Co. 338: 694–699 (2005)
Kim WK, Kang NE, Kim MH, Ha AW. Peanut sprout ethanol extract inhibits the adipocyte proliferation, differentiation, and matrix metalloproteinases activities in mouse fibroblast 3T3-L1 preadipocytes. Nutr. Res. Pract. 7: 160–165 (2013)
Sales PM, Souza PM, Simeoni LA, Silveira D. Alpha-amylase inhibitors: A review of raw material and isolated compounds from plant source. J. Pharm. Pharm. Sci. 15: 141–183 (2012)
Narita Y, Inouye K. Kinetic analysis and mechanism on the inhibition of chlorogenic acid and its components against porcine pancreas alpha-amylase isozymes I and II. J. Agr. Food Chem. 57: 9218–9225 (2009)
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337–342 (2006)
Baur JA, Sinclair DA. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 5: 493–506 (2006)
Seo JY, Kim SS, Kim HJ, Liu KH, Lee HY, Kim JS. Laxative effect of peanut sprout extract. Nutr. Res. Pract. 7: 262–266 (2013)
Choi JY, Choi DI, Lee JB, Yun SJ, Lee DH, Eun JB, Lee SC. Ethanol extract of peanut sprout induces Nrf2 activation and expression of antioxidant and detoxifying enzymes in human dermal fibroblasts: Implication for its protection against UVB-irradiated oxidative stress. Photochem. Photobiol. 89: 453–460 (2013)
Lin BS, Lien TF, Chao MR, Lai TY, Chang JC, Chou SJ, Lia HF, Chiou RYY. Toxicological and nutraceutical assessments of peanut sprouts as daily supplements to feed Sprague-Dawley rats for 18 weeks. J. Sci. Food Agr. 88: 2201–2207 (2008)
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Kim, S.S., Seo, J.Y., Kim, B.R. et al. Anti-obesity activity of peanut sprout extract. Food Sci Biotechnol 23, 601–607 (2014). https://doi.org/10.1007/s10068-014-0082-8
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DOI: https://doi.org/10.1007/s10068-014-0082-8