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Clinical manifestations of Behçet’s disease in a large cohort of Chinese patients: gender- and age-related differences

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A Correction to this article was published on 09 June 2020

This article has been updated

Abstract

Objectives

To investigate the clinical characteristics of Bechet’s disease (BD) with respect to gender and age in China.

Method

Clinical data of 489 BD patients admitted to Peking Union Medical College Hospital (PUMCH) and registered by the BD registry database established by PUMCH from March 2014 to January 2019 were collected and analyzed in this study. Demographics, medical histories, clinical manifestations, laboratory test results, imaging findings, assessment of disease activity, treatment regimen, as well as the outcomes were reviewed.

Results

A total of 489 BD patients were included in this study, among them 286 males (58.5%) and 203 females (41.5%) with a male-to-female ratio of 1.41 and a median age of 34 years (interquartile range 28–44 years old). The results revealed that ocular lesions (P = 0.005), vascular lesions(P < 0.001), pseudofolliculitis (P < 0.001), and positive pathergy test (P = 0.002) were more commonly found in males, while genital ulceration was more prevalent in females (P < 0.001). Vascular lesions (P = 0.024) and gastrointestinal ulcers (P = 0.010) were more common in BD patients after the age of 40, while pseudofolliculitis was more common in patients under the age of 40 (P = 0.004) and ocular lesions (P = 0.017) occurred mainly in patients under the age of 35. Male predominance of ocular involvement was more apparent in their third decades (Padjusted< 0.006), while vascular lesions were prominently presented in male patients at the age of 30–40 (Padjusted= 0.006). Female predominance of genital ulcers was observed in patients at the age of 30–40 (Padjusted< 0.006).

Conclusions

The clinical characteristics of BD were different with respect to gender and age.

Key Points

• Ocular and vascular lesions, pseudofolliculitis, and positive pathergy test were more common in male BD patients.

• Genital ulceration showed female predominance in BD patients.

• Vascular lesions and gastrointestinal ulcers were more common in older BD patients.

• Pseudofolliculitis and ocular lesions occurred mainly in younger BD patients.

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Change history

  • 09 June 2020

    The original version of this article, unfortunately, contained an error. The following Funding information was incomplete in the original publication; the authors have requested that this be noted

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Acknowledgments

We thank the health professional staff from the Department of Rheumatology & Clinical Immunology, Peking Union Medical College Hospital and the patients for their participation in this study.

Funding

This study was supported by grants from the National Key Research and Development Program: “Precise Medical Research” [2016YFC0906201], National Natural Science Foundation of China [81871299], the Chinese National Key Technology R&D Program, Ministry of Science and Technology [2017YFC0907601].

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Author notes

  1. Chaoran Li, Lu Li and Xiuhua Wu contributed equally to this work.

Authors and Affiliations

  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China

    Chaoran Li, Lu Li, Xiuhua Wu, Jing Shi, Jinjing Liu, Jiaxin Zhou, Li Wang, Xinping Tian, Xiaofeng Zeng & Wenjie Zheng

  2. National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Key Laboratory of Rheumatology & Clinical Immunology, Ministry of Education, Beijing, 100730, China

    Chaoran Li, Lu Li, Xiuhua Wu, Jing Shi, Jinjing Liu, Jiaxin Zhou, Li Wang, Xinping Tian, Xiaofeng Zeng & Wenjie Zheng

  3. Department of Rheumatology, General Hospital of Tianjin Medical University, Tianjin, 300050, China

    Xiuhua Wu

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  1. Chaoran Li
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Li, C., Li, L., Wu, X. et al. Clinical manifestations of Behçet’s disease in a large cohort of Chinese patients: gender- and age-related differences. Clin Rheumatol 39, 3449–3454 (2020). https://doi.org/10.1007/s10067-020-05026-2

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  • DOI: https://doi.org/10.1007/s10067-020-05026-2

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