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Study on the relationship between FFA and gout flare

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Abstract

Objectives

To detect the serum free fatty acid (FFA) concentration in patients with primary gouty arthritis (GA) and to explore the correlation between FFA and gout flare.

Method

Sixty patients with acute GA, 60 patients with GA remission, 60 patients with asymptomatic hyperuricemia (HUA), and 60 normal controls were enrolled in this study. Serum FFA concentration was detected by enzymatic determination in four groups, and the relationship between serum FFA, serum urate (SU), and other clinical and laboratory parameters was analyzed.

Results

(1) Serum FFA concentration was significantly higher in the acute GA than in the GA remission, the asymptomatic HUA, and the normal control (H = 72.191, P < 0.001). (2) There were no significant difference in serum triglyceride and low-density lipoprotein cholesterol (LDL-C) concentration between the acute GA, the GA remission, the asymptomatic HUA, and the normal control group.

Conclusions

FFA may be involved in the acute attack of gout in conditions of monosodium urate crystal deposition in the joints. Triglyceride and LDL-C may not be involved in the acute attack of gout. FFA may be used as an indicator to monitor the status of GA in clinical.

Key Points

• Lin Pei and Linfeng Xie designed the randomized controlled trial and were responsible for the development of the protocol.

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Acknowledgments

The authors gratefully acknowledge Ren Limin, Yao Haihong, Li Chun, An Yuan, Jia Yuan, and Chen Shi for their insightful suggestions and comments for the writing.

Funding

This research is supported by a grant from the National Natural Science Foundation of China (8177060718).

Author information

Author notes

  1. Lin Pei and Linfeng Xie contributed equally to this work.

Authors and Affiliations

  1. The Department of Laboratory Medicine, Peking University People’s Hospital, Beijing, People’s Republic of China

    Lin Pei & Han Zhang

  2. Putian University, Fujian, People’s Republic of China

    Linfeng Xie

  3. The Department of Rheumatology and Immunology, Peking University People’s Hospital, 11 Xizhimen South Street, Beijing, People’s Republic of China

    Junying Wu & Xuewu Zhang

Authors
  1. Lin Pei
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  2. Linfeng Xie
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  3. Junying Wu
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  4. Han Zhang
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  5. Xuewu Zhang
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Contributions

PL and XLF designed the randomized placebo-controlled trial and were responsible for the development of the protocol. ZH and WJY have overseen and conducted the practical part of the study. All authors approved the final version of the manuscript.

Corresponding author

Correspondence to Xuewu Zhang.

Ethics declarations

This study was approved by the Institutional Research Ethics Committees and carried out in compliance with the Helsinki Declaration.

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None.

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Pei, L., Xie, L., Wu, J. et al. Study on the relationship between FFA and gout flare. Clin Rheumatol 39, 1251–1255 (2020). https://doi.org/10.1007/s10067-019-04903-9

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  • DOI: https://doi.org/10.1007/s10067-019-04903-9

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