Skip to main content

Advertisement

Log in

Physical articular examination in the activity of rheumatoid arthritis: a systematic review of the literature

Systematic review of the literature regarding physical examination in rheumatoid arthritis

  • Original Article
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

To summarize evidence concerning the articular examination needed to determine rheumatoid arthritis (RA) activity (follow-up or control) via a systematic review. A search of Medline, Embase, Lilacs, SciELO, the Web of Science, the National Technical Reports Library, and the reference lists of relevant studies through March 2017 was conducted using a systematic methodology to identify studies of patients with RA older than 18 years in which a detailed description of the physical examination or a description of the components of the articular examination was provided. Of 8322 references, 74 studies were included according to the selection criteria, and 6 references were ultimately included at the end of the review. Most of the included studies (n = 5) were associated with a moderate risk of bias. There was great variability among the studies and the articular examination methods used. Some studies presented the examination with a complete specification of the technique (n = 2), the consensus of rheumatologists (n = 2), or training through audiovisual materials and face-to-face courses (n = 2), but none of the studies explicitly showed the technique by which the physical examination was performed. Despite the importance of the clinical evaluation and physical examination of patients with RA for diagnosis, prognosis, clinimetrics, and follow-up, evidence concerning how to perform the articular examination is scarce.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Gibofsky A (2012) Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care 18(13 Suppl):S295–S302

    PubMed  Google Scholar 

  2. Gabriel SE (2001) The epidemiology of rheumatoid arthritis. Rheum Dis Clin N Am 27(2):269–281. https://doi.org/10.1016/S0889-857X(05)70201-5

    Article  CAS  Google Scholar 

  3. Bautista-Molano W, Fernández-Avila D, Jiménez R, Cardozo R, Marín A, Soler MDP, Gómez O, Ruiz O (2016) Epidemiological profile of colombian patients with rheumatoid arthritis in a specialized care clinic. Reumatol Clin 12(6):313–318. https://doi.org/10.1016/j.reuma.2015.11.009

    Article  PubMed  Google Scholar 

  4. Nannini C, Medina-Velasquez YF, Achenbach SJ, Crowson CS, Ryu JH, Vassallo R, Gabriel SE, Matteson EL, Bongartz T (2013) Incidence and mortality of obstructive lung disease in rheumatoid arthritis: a population-based study. Arthritis Care & Research 65(8):1243–1250. https://doi.org/10.1002/acr.21986

    Article  Google Scholar 

  5. Amaya-Amaya J, Montoya-Sánchez L, Rojas-Villarraga A (2014) Cardiovascular involvement in autoimmune diseases. Biomed Res Int 2014:1–31. https://doi.org/10.1155/2014/367359

    Article  Google Scholar 

  6. Samanci N, Ozdem S, Akbas H, Mutlu D, Gultekin M, Arman M et al (2005) Diagnostic value and clinical significance of anti-CCP in patients with advanced rheumatoid arthritis. J Natl Med Assoc 97:1120–1126

    PubMed  PubMed Central  Google Scholar 

  7. Medina YF, Ortiz M, Barrera N, Chalem P, Motta A, Zamora F et al (2011) Relación de los anticuerpos anti-péptido citrulinado con manifestaciones osteo-articulares en una cohorte de pacientes con esclerodermia. Rev Colomb Reumatol 18:155–162

    Google Scholar 

  8. Nam JL, Ramiro S, Gaujoux-Viala C, Takase K, Leon-Garcia M, Emery P, Gossec L, Landewe R, Smolen JS, Buch MH (2014) Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2013 update of the EULAR recommendations for the management of rheumatoid arthritis. Ann Rheum Dis 73(3):516–528. https://doi.org/10.1136/annrheumdis-2013-204577

    Article  CAS  PubMed  Google Scholar 

  9. Lam S (2016) JAK inhibitors: a broadening approach in rheumatoid arthritis. Drugs Today Barc Spain: 1998 52:467–469. https://doi.org/10.1358/dot.2016.52.8.2543995

    Article  CAS  Google Scholar 

  10. Cárdenas M, de la Fuente S, Castro-Villegas MC, Romero-Gómez M, Ruiz-Vílchez D, Calvo-Gutiérrez J, Escudero-Contreras A, del Prado JR, Collantes-Estévez E, Font P (2016) Cost-effectiveness of clinical remission by treat to target strategy in established rheumatoid arthritis: results of the CREATE registry. Rheumatol Int 36(12):1627–1632. https://doi.org/10.1007/s00296-016-3583-3

    Article  PubMed  Google Scholar 

  11. Dwyer KA, Coty MB, Smith CA, Dulemba S, Wallston KA (2001) A comparison of two methods of assessing disease activity in the joints. Nurs Res 50(4):214–221. https://doi.org/10.1097/00006199-200107000-00005

    Article  CAS  PubMed  Google Scholar 

  12. Salaffi F, Cimmino MA, Leardini G, Gasparini S, Grassi W, Epidemiology Study Grp Italian, S (2009) Disease activity assessment of rheumatoid arthritis in daily practice: validity, internal consistency, reliability and congruency of the disease activity score including 28 joints (DAS28) compared with the clinical disease activity index (CDAI). Clin Exp Rheumatol 27:552–559

    CAS  PubMed  Google Scholar 

  13. Vega-Morales D, Esquivel-Valerio JA, Garza-Elizondo MA (2015) Do rheumatologists know how to squeeze? Evaluations of Gaenslen’s maneuver. Rheumatol Int 35(12):2037–2040. https://doi.org/10.1007/s00296-015-3354-6

    Article  PubMed  Google Scholar 

  14. Levy G, Cheetham C, Cheatwood A, Burchette R (2007) Validation of patient-reported joint counts in rheumatoid arthritis and the role of training. J Rheumatol 34(6):1261–1265

    PubMed  Google Scholar 

  15. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ (Clinical Research Ed) 339:b2535

    Article  Google Scholar 

  16. Funovits J, Aletaha D, Bykerk V, Combe B, Dougados M, Emery P, Felson D, Hawker G, Hazes JM, Huizinga T, Kay J, Kvien TK, Smolen JS, Symmons D, Tak PP, Silman A (2010) The 2010 American College of Rheumatology/European league against rheumatism classification criteria for rheumatoid arthritis: methodological report phase I. Ann Rheum Dis 69(9):1589–1595. https://doi.org/10.1136/ard.2010.130310

    Article  PubMed  Google Scholar 

  17. Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ (Clinical Res Ed) 355:i4919

    Google Scholar 

  18. van Riel PLCM, van Gestel AM, Scott DL, European League against Rheumatism and Standing Committee for International Clinical Studies including Therapeutic Trials (2000) EULAR handbook of clinical assessments in rheumatoid arthritis: on behalf of the EULAR Standing Committee for International Clinical Studies Including Therapeutic Trials -ESCISIT (chairman, Piet L.C.M van Riel). Van Zuiden, The Netherlands

  19. Higgins JPT, Green S, Cochrane Collaboration, editors (2008) Cochrane handbook for systematic reviews of interventions. Wiley-Blackwell, Chichester

    Book  Google Scholar 

  20. Cheung PP, Dougados M, Andre V, Balandraud N, Chalès G, Chary-Valckenaere I, Dernis E, Gill G, Gilson M, Guis S, Mouterde G, Pavy S, Pouyol F, Marhadour T, Richette P, Ruyssen-Witrand A, Soubrier M, Nguyen M, Gossec L (2014) The learning curve of nurses for the assessment of swollen and tender joints in rheumatoid arthritis. Joint Bone Spine 81(2):154–159. https://doi.org/10.1016/j.jbspin.2013.06.006

    Article  PubMed  Google Scholar 

  21. Grunke M, Antoni CE, Kavanaugh A, Hildebrand V, Dechant C, Schett G et al (2010) Standardization of joint examination technique leads to a significant decrease in variability among different examiners. J Rheumatol 37(4):860–864. https://doi.org/10.3899/jrheum.090195

    Article  PubMed  Google Scholar 

  22. Kane D, Balint PV, Sturrock RD (2003) Ultrasonography is superior to clinical examination in the detection and localization of knee joint effusion in rheumatoid arthritis. J Rheumatol 30(5):966–971

    PubMed  Google Scholar 

  23. Kim HA, Kim SH, Seo YI (2007) Ultrasonographic findings of the shoulder in patients with rheumatoid arthritis and comparison with physical examination. J Korean Med Sci 22(4):660–666. https://doi.org/10.3346/jkms.2007.22.4.660

    Article  PubMed  PubMed Central  Google Scholar 

  24. Naredo E, Bonilla G, Gamero F, Uson J, Carmona L, Laffon A (2005) Assessment of inflammatory activity in rheumatoid arthritis: a comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis 64(3):375–381. https://doi.org/10.1136/ard.2004.023929

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Stone MA, White LM, Gladman DD, Inman RD, Chaya S, Lax M et al (2009) Significance of clinical evaluation of the metacarpophalangeal joint in relation to synovial/bone pathology in rheumatoid and psoriatic arthritis detected by magnetic resonance imaging. J Rheumatol 36(12):2751–2757. https://doi.org/10.3899/jrheum.080205

    Article  PubMed  Google Scholar 

  26. Grassi W, De Angelis R, Lamanna G, Cervini C (1998) The clinical features of rheumatoid arthritis. Eur J Radiol 27(Suppl 1):S18–S24. https://doi.org/10.1016/S0720-048X(98)00038-2

    Article  PubMed  Google Scholar 

  27. Assistance Publique – Hôpitaux de Paris (Fr) (2015) LE RHUMATISMES en 100 questions [Internet]. Paris, France

  28. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS et al (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324. https://doi.org/10.1002/art.1780310302

    Article  CAS  PubMed  Google Scholar 

  29. Muirden KD (1998) Education in rheumatology. Ann Acad Med Singap 27:24–28

    CAS  PubMed  Google Scholar 

  30. Akesson K, Dreinhöfer KE, Woolf AD (2003) Improved education in musculoskeletal conditions is necessary for all doctors. Bull World Health Organ 81(9):677–683

    PubMed  PubMed Central  Google Scholar 

  31. Olson DP, Roth KE (2007) Diagnostic tools and the hands-on physical examination. Virtual Mentor 9(2):113–118. https://doi.org/10.1001/virtualmentor.2007.9.2.jdsc1-0702

    Article  PubMed  Google Scholar 

  32. Castrejon I, McCollum L, Tanriover MD, Pincus T (2012) Importance of patient history and physical examination in rheumatoid arthritis compared to other chronic diseases: results of a physician survey. Arthritis Care Res 64(8):1250–1255. https://doi.org/10.1002/acr.21650

    Google Scholar 

  33. Walsh CAE, Mullan RH, Minnock PB, Slattery C, FitzGerald O, Bresnihan B (2008) Consistency in assessing the disease activity Score-28 in routine clinical practice. Ann Rheum Dis 67(1):135–136. https://doi.org/10.1136/ard.2007.076885

    Article  CAS  PubMed  Google Scholar 

  34. Cheung PP, Dougados M, Andre V, Balandraud N, Chales G, Chary-Valckenaere I, Chatelus E, Dernis E, Gill G, Gilson M, Guis S, Mouterde G, Pavy S, Pouyol F, Marhadour T, Richette P, Ruyssen-Witrand A, Soubrier M, Gossec L (2013) Improving agreement in assessment of synovitis in rheumatoid arthritis. Joint, Bone, Spine. Rev Rhum 80(2):155–159. https://doi.org/10.1016/j.jbspin.2012.07.014

    Google Scholar 

  35. Tugwell P, Boers M (1993) Developing consensus on preliminary core efficacy endpoints for rheumatoid arthritis clinical trials. OMERACT committee. J Rheumatol 20(3):555–556

    CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We would like to thank Dr. Eric Matteson for his support in acquiring some older and difficult-to-obtain articles.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yimy F. Medina.

Ethics declarations

Disclosures

None.

Financial support

The present study was supported by an unrestricted grant from AbbVie Laboratories.

Ethical standards

The manuscript does not contain any clinical or patient information because of its SRL design.

Electronic supplementary material

ESM 1

(DOCX 12 kb).

ESM 2

(XLSX 16 kb).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Medina, Y.F., Ruíz-Gaviria, R.E., Buitrago-Lopez, A. et al. Physical articular examination in the activity of rheumatoid arthritis: a systematic review of the literature. Clin Rheumatol 37, 1457–1464 (2018). https://doi.org/10.1007/s10067-018-4015-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-018-4015-4

Keywords

Navigation