Abstract
Functional limitation is often complained by patients with ankylosing spondylitis (AS). With a rising number of patients suffering from AS, there are a limited number of reports focusing on functional limitation of AS in Chinese patients. This study was conducted to investigate the level of functional limitation and explore its associations with demographic, disease-related factors. A total of 303 AS outpatients were recruited in this cross-sectional study from a tertiary general hospital in Southwest China. Functional limitation was measured by the Bath Ankylosing Spondylitis Functional Index (BASFI). Other data were collected by the following questionnaires: the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Patient Global Score (BAS-G), and the Pittsburgh Sleep Quality Index Questionnaire (PSQI). Finally, 295 outpatients with AS completed this survey. The median BASFI was 0.80. Worse function limitation was found in outpatients with extra-spinal manifestation, older age, lower household income, more back pain, higher disease activity and morning stiffness, poorer sleep, and worse patient’s well-being (all P < 0.05). Multivariate regression analysis indicated that patient’s well-being (P < 0.001), disease activity (P < 0.001), and disease duration (P < 0.05) were the positive predictors of functional limitation. AS outpatients in Southwest China had a mild level of functional limitation. The factors associated with functional limitation included disease duration, disease activity, and patients’ well-being, which should be taken into consideration when assessing functional limitation of AS outpatients. Besides, more comprehensive and targeted interventions should be conducted for AS patients as early as possible, which will be effective to improve functional outcome.
Similar content being viewed by others
References
Jürgen B, Joachim S (2007) Ankylosing spondylitis. Lancet 369(9570):1379–1390
Dai SM, Han XH, Zhao DB, Shi YQ, Liu Y, Meng JM (2003) Prevalence of rheumatic symptoms, rheumatoid arthritis, ankylosing spondylitis, and gout in Shanghai, China: a COPCORD study. J Rheumatol 30(10):2245–2251
Zeng QY (2003) Ankylosing spondylitis in Shantou, China: 15 years’ clinical experience. J Rheumatol 30(8):1816–1821
Cornell P, Oliver SM (2004) Ankylosing spondylitis: clinical update. Musculoskeletal Care 2(3):187–193
Tam LS, Chan KY, Li EK (2007) The influence of illness and variables associated with functional limitations in Chinese patients with ankylosing spondylitis. J Rheumatol 34(5):1032–1039
Akkoç N, Direskeneli H, Erdem H, Gül A, Kabasakal Y, Kiraz S, Balkan Tezer D, Hacıbedel B, Hamuryudan V (2015) Direct and indirect costs associated with ankylosing spondylitis and related disease activity scores in Turkey. Rheumatol Int 35(9):1473–1478
Cooksey R, Husain MJ, Brophy S, Davies H, Rahman MA, Atkinson MD, Phillips CJ, Siebert S (2015) The cost of ankylosing spondylitis in the UK using linked routine and patient-reported survey data. PLoS One 10(7):e0126105
Ward MM (2002) Functional disability predicts total costs in patients with ankylosing spondylitis. Arthritis Rheum 46(1):223–231
Lee TJ, Park BH, Kim JW, Shin K, Lee EB, Song YW (2014) Cost-of-illness and quality of life in patients with ankylosing spondylitis at a tertiary hospital in Korea. J Korean Med Sci 29(2):190–197
Cansu DÜ, Çalışır C, Savaş Yavaş U, Kaşifoğl T, Kormaz C (2011) Predictors of radiographic severity and functional disability in Turkish patients with ankylosing spondylitis. Clin Rheumatol 30(4):557–562
Mustur D, Vesović-potić V, Stanisavljević D, Ille T, Ille M (2009) Assessment of functional disability and quality of life in patients with ankylosing spondylitis. Srp Arh Celok Lek 137(9–10):524–528
Robertson LP, Davis MJ (2004) A longitudinal study of disease activity and functional status in a hospital cohort of patients with ankylosing spondylitis. Rheumatology 43(12):1565–1568
Ward MM (1999) Health-related quality of life in ankylosing spondylitis: a survey of 175 patients. Arthritis Care Res 12(4):247–255
Stone M, Warren RW, Bruckel J, Cooper D, Cortinovis D, Inman RD (2005) Juvenile-onset ankylosing spondylitis is associated with worse functional outcomes than adult-onset ankylosing spondylitis. Arthritis Rheum 53(3):445–451
Van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 27(4):361–368
Calin A, Garrett S, Whitelock H, Kennedy LG, O'Hea J, Mallorie P, Jenkinson T (1994) A new approach to defining functional ability in ankylosing spondylitis: the development of the bath ankylosing spondylitis functional index. J Rheumatol 21(12):2281–2285
Bodur H, Şebnem A, Rezvani A, Buģdaycı DS, Ḉevik R, Birtane M et al (2010) Quality of life and related variables in patients with ankylosing spondylitis. Qual Life Res 20(4):543–549
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A (1994) A new approach to defining disease status in ankylosing spondylitis: the bath ankylosing spondylitis disease activity index. J Rheumatol 21(12):2286–2291
Jones SD, Steiner A, Garrett SL, Calin A (1996) The bath ankylosing spondylitis patient global score (BAS-G). Br J Rheumatol 35(1):66–71
Tsai PS, Wang SY, Wang MY, Su CT, Yang TT, Huang CJ, Fang SC (2005) Psychometric evaluation of the Chinese version of the Pittsburgh Sleep Quality Index (CPSQI) in primary insomnia and control subjects. Qual Life Res 14(8):1943–1952
Liu X, Tang M, Hu L, Wang A, Wu H, Zhao G, Gao C, Li W (1996) Reliability and validity of the Pittsburgh Sleep Quality Index. Chin J Psychiatry 29(2):103–107
Jiang Y, Yang M, Wu H, Song H, Zhan F, Liu S, Gao G, Liu Z, Hu Z, He P, Zhang S, Hu Z, Lin Z, Zhang Y, Li Y, Shen L, Huang A, Liao Z, Cao S, Wei Y, Li L, Li Q, Lv Q, Qi J, Huang J, Li T, Jin O, Pan Y, Gu J (2015) The relationship between disease activity measured by the BASDAI and psychological status, stressful life events, and sleep quality in ankylosing spondylitis. Clin Rheumatol 34(3):503–510
Ward MM (2002) Predictors of the progression of functional disability in patients with ankylosing spondylitis. J Rheumatol 29(7):1420–1425
Doran MF, Sinead B, Kirsten MK, Gordon T, Andre C (2003) Predictors of long-term outcome in ankylosing spondylitis. J Rheumatol 30(2):316–320
Landewé R, Dougados M, Mielants H, van der Tempel H, van der Heijde D (2009) Physical function in ankylosing spondylitis is independently determined by both disease activity and radiographic damage of the spine. Ann Rheum Dis 68(6):863–867
Jang JH, Green CE, Assassi S, Reveille JD, Ward MM, Weisman MH, Nicassio PM (2011) The contribution of disease activity on functional limitations over time through psychological mediators: a 12-month longitudinal study in patients with ankylosing spondylitis. Rheumatology(Oxford) 50(11):2087–2092
Dagfinrud H, Kvien TK, Hagen KB (2008) Physiotherapy interventions for ankylosing spondylitis. Cochrane Database Syst Rev 1:CD002822
Martins NA, Furtado GE, Campos MJ, Leitão JC, Filaire E, Ferreira JP (2014) Exercise and ankylosing spondylitis with New York modified criteria: a systematic review of controlled trials with meta-analysis. Acta Reumatol Port 39(4):298–308
Wei JC, Wong RH, Huang JH, Yu CT, Chou CT, Jan MS, Tsay GJ, Chou MC, Lee HS (2007) Evaluation of internal consistency and re-test reliability of bath ankylosing spondylitis indices in a large cohort of adult and juvenile spondylitis patients in Taiwan. Clin Rheumatol 26(10):1685–1691
Bakker C, Boers M, van der Linden S (1993) Measures to assess ankylosing spondylitis: taxonomy, review and recommendations. J Rheumatol 20(10):1724–1730
Stone MA, Bruckel J, Warren RW, Kurtinecz M, Inman RD (2003) Progressive disability and functional impairment in females and males with ankylosing spondylitis is predicted by longer disease duration. Arthritis Rheum 48(9):S172
Lin Z, Gu J, He P, Gao J, Zuo X, Ye Z, Shao F, Zhan F, Lin J, Li L, Wei Y, Xu M, Liao Z, Lin Q (2011) Multicenter validation of the value of BASFI and BASDAI in Chinese ankylosing spondylitis and undifferentiated spondyloarthropathy patients. Rheumatol Int 31(2):233–238
Dalyan M, Güner A, Tuncer S, Bilgil A, Arasil T (1999) Disability in ankylosing spondylitis. Disabil Rehabil 21(2):74–79
Boonen A, vander Cruyssen B, de Vlam K, Steinfeld S, Ribbens C, Lenaerts J, Van den Bosch F, Mielants H, Dewulf L, Vastesaeger N (2009) Spinal radiographic changes in ankylosing spondylitis: association with clinical characteristics and functional outcome. J Rheumatol 36(6):1249–1255
van Genderen S, van den Borne C, Geusens P, van der Linden S, Boonen A, Plasqui G (2014) Physical functioning in patients with ankylosing spondylitis: comparing approaches of experienced ability with self-reported and objectively measured physical activity. J Clin Rheumatol 20(3):133–137
Li Y, Zhang S, Zhu J, Du X, Huang F (2012) Sleep disturbances are associated with increased pain, disease activity, depression, and anxiety in ankylosing spondylitis: a case-control study. Arthritis Res Ther 14(5):R215
Hakkou J, Rostom S, Mengat M, Aissaoui N, Bahiri R, Hajjaj-Hassouni N (2013) Sleep disturbance in Moroccan patients with ankylosing spondylitis: prevalence and relationships with disease-specific variables, psychological status and quality of life. Rheumatol Int 33(2):285–290
Batmaz İ, Sarıyıldız MA, Dilek B, Bez Y, Karakoç M, Çevik R (2013) Sleep quality and associated factors in ankylosing spondylitis: relationship with disease parameters, psychological status and quality of life. Rheumatol Int 33(4):1039–1045
Acknowledgments
We would like to thank all the patients for finishing our investigation and the investigators for collecting data.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
This study was approved by the West China Hospital Medical Ethics Committee. Written informed consents were obtained from all the patients.
Disclosures
None.
Rights and permissions
About this article
Cite this article
Song, Y., Wang, C. & Chen, H. Functional limitation and associated factors in outpatients with ankylosing spondylitis in Southwest China. Clin Rheumatol 36, 871–877 (2017). https://doi.org/10.1007/s10067-017-3563-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-017-3563-3