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Mortality in patients with ankylosing spondylitis in Argentina

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Abstract

Some reports describe an increased mortality in patients with ankylosing spondylitis (AS) compared to the general population. The aims of this study were to evaluate the cumulative survival in patients with AS and to establish possible factors associated with mortality. In cross-sectional retrospective study, AS patients were included according to 1984 modified NY criteria, in the 2000–2010 period, the prevalence of mortality was determined by review of medical records, telephone contact, family reports, and death certificates, and it was compared with mortality in Argentina’s general population. One hundred twenty-seven patients were studied, 96 (75.6 %) were male, median age 49 years (interquartile range (IQR) 34–60) and median disease duration 8 years (IQR 4–17). During the follow-up period, 9 patients died (7.1 %). The median estimated survival from diagnosis of AS was 39 years (IQR 34–50) and median cumulative survival was 76 years (IQR 74–85). Cardiovascular disease was the most frequent cause of death (5/9 patients). Deceased patients had a mean age and a mean AS disease duration significantly higher than living patients (68.1 ± 12.4 years vs 46.4 ± 15.09 years, p = 0.0001 and 33 ± 13.7 years vs 12 ± 10.7 years, p = 0.001, respectively), higher frequency of total surgeries [3/5 (60 %) vs 5/105 (4.76 %), p = 0.002] and cauda equina syndrome [3/6 (50 %) vs 2/116 (1.72 %), p = 0.001], respectively. Frequency of mortality in AS patients was higher than the crude mortality rate of Argentina’s general population in the same period, with cardiovascular cause being the most frequent one.

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References

  1. Mok CC, Kwok RC, Yip PS (2013) Effect of renal disease on the standardized mortality ratio and life expectancy of patients with systemic lupus erythematosus. Arthritis Rheum 65(8):2154–2160

    Article  CAS  PubMed  Google Scholar 

  2. Lee J, Dhillon N, Pope J (2013) All-cause hospitalizations in systemic lupus erythematosus from a large Canadian referral centre. Rheumatology (Oxford) 52(5):905–909

    Article  Google Scholar 

  3. Teh CL, Ling GR (2013) Causes and predictors of mortality in hospitalized lupus patient in Sarawak General Hospital, Malaysia. Lupus 22(1):106–111

    Article  CAS  PubMed  Google Scholar 

  4. Koivuniemi R, Paimela L, Leirisalo-Repo M (2009) Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy. Clin Rheumatol 28(12):1443–1447

    Article  PubMed  Google Scholar 

  5. Zochling J, Braun J (2008) Mortality in ankylosing spondylitis. Clin Exp Rheumatol (5 Suppl 51):S80–4

  6. Brown WM, Doll R (1965) Mortality from cancer and other causes after radiotherapy for ankylosing spondylitis. Br Med J 2(5474):1327–1332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Darby SC, Doll R, Gill SK, Smith PG (1987) Long term mortality after a single treatment course with X-rays in patients for ankylosing spondylitis. Br J Cancer 55(2):179–190

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Braun J, Pincus T (2002) Mortality, course of disease and prognosis of patients with ankylosing spondylitis. Clin Exp Rheumatol 20(Suppl28):S16–S22

    CAS  PubMed  Google Scholar 

  9. Smith PG, Doll R, Radford EP (1977) Cancer mortality among patients with ankylosing spondylitis not given x-ray therapy. Br J Radiol 50(598):728–734

    Article  CAS  PubMed  Google Scholar 

  10. Myllykangas-Lousujärvi K, Aho K, Lehtinen K, Kautiainen H, Hakala M (1998) Increased incidence of alcohol related deaths from accidents and violence in subjects with ankylosing spondylitis. Br J Rheumatol 37(6):688–690

    Article  Google Scholar 

  11. van der Linden S, Valkenburg HA, Cats A (1984) Evaluation of diagnostic criteria for ankylosing spondylitis. Arthritis Rheum 27(4):361–368

    Article  PubMed  Google Scholar 

  12. Ministerio de Salud de la Nación, Dirección de Epidemiología (2010–2011) Información suministrada para el boletín “Indicadores básicos Argentina 2012”. Ministerio de Salud Presidencia de la Nación, Organización panamericana de la Salud y Oficina Regional de la Organización Mundial de la Salud. www.msal.gov.ar/images/stories/pdf/indicadores-basicos-2012

  13. Carbone LD, Cooper C, Michet CJ, Atkinson EJ, O’Fallon WM, Melton LJ (1992) Ankylosing spondylitis in Rochester, Minnesota 1935–1989. Arthritis Rheum 32(12):1476–1482

    Article  Google Scholar 

  14. Khan MA, Khan MK, Kushner I (1981) Survival among patients with ankylosing spondylitis: a life table analysis. J Rheumatol 8(1):86–90

    CAS  PubMed  Google Scholar 

  15. http://www.who.int/gho/publications/world_health_statistics/es/

  16. Bakland G, Gran JT, Nossent JC (2011) Increased mortality in ankylosing spondylitis is related to disease activity. Ann Rheum Dis 70(11):1921–1925

    Article  PubMed  Google Scholar 

  17. Genre F, López-Mejías R, Miranda-Filloy J, Ubilla B, Carnero-López B, Blanco R, González-Gay M (2014) Adipokines, biomarkers of endothelial activation, and metabolic syndrome in patients with ankylosing spondylitis. BioMed Res Int Article ID 860651,11 pages

  18. Peters MJ, van der Horst-Bruinsma IA, Dijkmans BA, Nurmohamed MT (2004) Cardiovascular risk profile of patients with spondyloarthritides particularly ankylosing spondylitis and psoriatic arthritis. Semin Arthritis Rheum 34(3):585–592

    Article  PubMed  Google Scholar 

  19. Lin C-W, Huang Y-P, Chiu Y-H, Ho Y-T, Pan S-L (2014) Increased risk of ischemic stroke in young patients with ankylosing spondylitis: a population-based longitudinal follow-up study. PLoS One 9(4):e94027

    Article  PubMed  PubMed Central  Google Scholar 

  20. Mathieu S, Motreff P, Soubrier M (2010) Spondyloarthropathies: an independent cardiovascular risk factor? Joint Bone Spine 77(6):542–545

    Article  PubMed  Google Scholar 

  21. Heeneman S, Daemen MJ (2007) Cardiovascular risks in spondyloarthritis. Curr Opin Rheumatol 19(4):358–362

    Article  PubMed  Google Scholar 

  22. Kirmayr K, Schneeberger EE, Arturi P, Quevedo S, Maldonado Cocco JA, Citera G (2012) Riesgo cardiovascular en una cohorte de pacientes con espondilitis anquilosante. Rev Arg Reumatol 23(4):18–24

    Google Scholar 

  23. Lehtinen K (1993) Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis 52(3):174–176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Radford EP, Doll R, Smith PG (1977) Mortality among patients with ankylosing spondylitis not given X-ray therapy. N Engl J Med 297(11):572–576

    Article  CAS  PubMed  Google Scholar 

  25. Ortega R, Font P, Castro MC, Calvo J, Zarco P, Almodóvar R et al (2005) Diferente expresión clínica de los pacientes con espondilitis anquilosante según el sexo en función del tiempo de evolución. Datos de REGISPONSER. Reumatol Clín 9(4):221–225

    Article  Google Scholar 

  26. Tournadre A, Pereira B, Lhoste A, Dubost JJ, Ristori JM, Claudepierre P et al (2013) Differences between women and men with recent-onset axial spondyloarthritis: results from a prospective multicenter French cohort. Arthritis Care Res 65(9):1482–1489

    Article  CAS  Google Scholar 

  27. van der Horst-Bruinsma IE, Zack DJ, Szumski A, Koenig AS (2013) Female patients with ankylosing spondylitis: analysis of the impact of gender across treatment studies. Ann Rheum Dis 72(7):1221–1224

    Article  PubMed  Google Scholar 

  28. Caron T, Bransford R, Nguyen Q, Agel J, Chapman J, Bellabarba C (2010) Spine fractures in patients with ankylosing spinal disorders. Spine (Phila Pa 1976) 35(11):E458–E464

    Article  Google Scholar 

  29. Amor B, Santos RS, Nahal R, Listrat V, Dougados M (1994) Predictive factors for the long term outcome of spondyloarthropathies. J Rheumatol 21(10):1883–1887

    CAS  PubMed  Google Scholar 

  30. Vander Cruyssen B, Vastesaeger N, Collantes-Estevez E (2013) Hip disease in ankylosing spondylitis. Curr Opin Rheumatol 25(4):448–454

    Article  CAS  PubMed  Google Scholar 

  31. Tyrrell PNM, Davies AM, Evans N (1994) Neurological disturbances in ankylosing spondylitis. Ann Rheum Dis 53(11):714–717

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Lehtinen K (1983) The mortality and causes of death of patients with “hypergamma type” of ankylosing spondylitis. Scand J Rheumatol 12(1):3–4

    Article  CAS  PubMed  Google Scholar 

  33. Lehtinen K (1983) 76 patients with ankylosing spondylitis seen after 30 years of disease. Scand J Rheumatol 12(1):5–11

    Article  CAS  PubMed  Google Scholar 

  34. Lethinen K (1980) Cause of death in 79 patients with ankylosing spondylitis. Scand J Rheumatol 9(3):145–147

    Article  Google Scholar 

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Authors and Affiliations

  1. Rheumatology Section, Instituto de Rehabilitación Psicofísica (IREP), Echeverria 955, Ciudad Autonoma de Buenos Aires, Argentina

    Emilio Andres Buschiazzo, Emilce Edith Schneeberger, Fernando Andres Sommerfleck, Cesar Ledesma & Gustavo Citera

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  1. Emilio Andres Buschiazzo
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  2. Emilce Edith Schneeberger
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  3. Fernando Andres Sommerfleck
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Correspondence to Emilio Andres Buschiazzo.

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Buschiazzo, E.A., Schneeberger, E.E., Sommerfleck, F.A. et al. Mortality in patients with ankylosing spondylitis in Argentina. Clin Rheumatol 35, 2229–2233 (2016). https://doi.org/10.1007/s10067-016-3336-4

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  • DOI: https://doi.org/10.1007/s10067-016-3336-4

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