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Rheumatologic manifestations of primary immunodeficiency diseases

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Abstract

In the last 5 years, several hundred articles have been published concerning the link between primary immunodeficiency disease (PID) and rheumatologic diseases. Although rheumatologic complications were originally thought to be at the opposite ends of the spectrum of immunopathologic manifestations, they are now all being considered secondary manifestations of a causative primary “immune derangement.” For the rheumatologist, it is important to be able to identify patients who may present with typical rheumatologic findings but who have an underlying PID. In a systematic manner, this overview addresses both the systemic and organ-based rheumatologic diseases which have known associations with primary immunodeficiencies, and explores how immunodeficiency may actually cause these clinical manifestations.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Allergy/Immunology, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA, 70118, USA

    V. R. Dimitriades & R. Sorensen

  2. Department of Pediatrics, Division of Rheumatology, Louisiana State University Health Sciences Center, 200 Henry Clay Avenue, New Orleans, LA, 70118, USA

    V. R. Dimitriades

  3. Faculty of Medicine, University of La Frontera, Francisco Salazar 1145, Temuco, Chile

    R. Sorensen

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  1. V. R. Dimitriades
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Correspondence to V. R. Dimitriades.

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Dimitriades, V.R., Sorensen, R. Rheumatologic manifestations of primary immunodeficiency diseases. Clin Rheumatol 35, 843–850 (2016). https://doi.org/10.1007/s10067-016-3229-6

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  • DOI: https://doi.org/10.1007/s10067-016-3229-6

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