Zusammenfassung
Schlaganfälle gehören zu den weltweit führenden Ursachen für Behinderung und Tod. Da der Erfolg der Rekanalisationsbehandlung mit intravenöser Thrombolyse oder mechanischer Thrombektomie zeitabhängig ist („Time is brain“), besteht ein großer Druck zur raschen Therapieentscheidung. Dies erhöht die Wahrscheinlichkeit einer Fehldiagnose, da schlaganfallähnliche Symptome auch bei anderen Krankheiten vorliegen können. Der vorliegende Beitrag soll einen Überblick über die häufigsten Krankheitsbilder geben, die einen Schlaganfall vortäuschen („stroke mimics“). Eine der vielen Herausforderungen für ein in der Primärversorgung tätiges Notfallteam besteht darin, die wesentlichen „mimics“ und ihre diagnostischen Besonderheiten zu kennen und somit die Rate der Fehldiagnosen zu reduzieren.
Abstract
Strokes are a leading cause of disability and death worldwide. Since the success of recanalization treatment with intravenous thrombolysis or mechanical thrombectomy is time critical (“time is brain”), there is a great pressure for quick therapy decisions. This may increase the likelihood of a misdiagnosis, as stroke-like symptoms can also be present in other diseases. This article is intended to provide an overview of the most common clinical conditions that present stroke-like symptoms (stroke mimics). One of the many challenges of the emergency team working in primary care is to recognize the essential mimics and to triage them accordingly.
Literatur
Brigo F, Nardone R, Ausserer H, Storti M, Tezzon F, Manganotti P, Bongiovanni LG (2013) The diagnostic value of urinary incontinence in the differential diagnosis of seizures. Seizure 22(2):85–90
Brosinski CM (2014) Implementing diagnostic reasoning to differentiate Todd’s paralysis from acute ischemic stroke. Adv Emerg Nurs J 36(1):78–86
Cordonnier C, Oppenheim C, Lamy C, Meder JF, Mas JL (2005) Serial diffusion and perfusion-weighted MR in transient hypoglycemia. Neurology 65(1):175
Edlow BL, Hurwitz S, Edlow JA (2017) Diagnosis of DWI-negative acute ischemic stroke: a meta-analysis. Neurology 89(3):256–262
Erbguth F (2017) Stroke mimics und stroke Chamäleons – Differenzialdiagnose des Schlaganfalls [stroke mimics and stroke chameleons: differential diagnosis of stroke. Fortschr Neurol Psychiatr 85(12):747–764
Fandler-Höfler S, Enzinger C, Gattringer T (2020) Speechless from pain: migraine with prolonged aura. Lancet 396(10246):e11
Fernandes PM, Whiteley WN, Hart SR, Al-Shahi Salman R (2013) Strokes: mimics and chameleons. Pract Neurol 13(1):21–28
Förster A, Griebe M, Wolf ME, Szabo K, Hennerici MG, Kern R (2012) How to identify stroke mimics in patients eligible for intravenous thrombolysis? J Neurol 259(7):1347–1353
Gargalas S, Weeks R, Khan-Bourne N, Shotbolt P, Simblett S, Ashraf L, Doyle C, Bancroft V, David AS (2017) Incidence and outcome of functional stroke mimics admitted to a hyperacute stroke unit. J Neurol Neurosurg Psychiatry 88(1):2–6. https://doi.org/10.1136/jnnp-2015-311114
Goyal N, Male S, Al Wafai A, Bellamkonda S, Zand R (2015) Cost burden of stroke mimics and transient ischemic attack after intravenous tissue plasminogen activator treatment. J Stroke Cerebrovasc Dis 24(4):828–833
Hand PJ, Kwan J, Lindley RI, Dennis MS, Wardlaw JM (2006) Distinguishing between stroke and mimic at the bedside: the brain attack study. Stroke 37(3):769–775
Kim JT, Fonarow GC, Smith EE, Reeves MJ, Navalkele DD, Grotta JC, Grau-Sepulveda MV, Hernandez AF, Peterson ED, Schwamm LH, Saver JL (2017) Treatment with tissue plasminogen activator in the golden hour and the shape of the 4.5-hour time-benefit curve in the national United States get with the guidelines-stroke population. Circulation 135(2):128–139
Kissoon NR, Cutrer FM (2017) Aura and other neurologic dysfunction in or with migraine. Headache 57(7):1179–1194
Liberman AL, Prabhakaran S (2017) Stroke chameleons and stroke mimics in the emergency department. Curr Neurol Neurosci Rep 17(2):15
Liberman AL, Liotta EM, Caprio FZ, Ruff I, Maas MB, Bernstein RA, Khare R, Bergman D, Prabhakaran S (2015) Do efforts to decrease door-to-needle time risk increasing stroke mimic treatment rates? Neurol Clin Pract 5(3):247–252
McWhirter L, Stone J, Sandercock P, Whiteley W (2011) Hoover’s sign for the diagnosis of functional weakness: a prospective unblinded cohort study in patients with suspected stroke. J Psychosom Res 71(6):384–386
Merino JG, Luby M, Benson RT, Davis LA, Hsia AW, Latour LL, Lynch JK, Warach S (2013) Predictors of acute stroke mimics in 8187 patients referred to a stroke service. J Stroke Cerebrovasc Dis 22(8):e397–e403
Mohammad A, Ortiz R, Vydyula R, Mina B (2013) Stroke code overuse or misuse—a need for structured support systems. Crit Care Med 41(12):A103–A104
Morgenstern LB, Frankowski RF (1999) Brain tumor masquerading as stroke. J Neurooncol 44(1):47–52
Moulin S, Leys D (2019) Stroke mimics and chameleons. Curr Opin Neurol 32(1):54–59
Norris JW, Hachinski VC (1982) Misdiagnosis of stroke. Lancet 1(8267):328–331
Okano Y, Ishimatsu K, Kato Y, Yamaga J, Kuwahara K, Okumoto K, Wada K (2018) Clinical features of stroke mimics in the emergency department. Acute Med Surg 5(3):241–248
Olesen J (2018) International classification of headache disorders. Lancet Neurol 17(5):396–397
Polverino P, Caruso P, Ridolfi M, Furlanis G, Naccarato M, Sartori A, Manganotti P (2019) Acute isolated aphasia as a challenging symptom in the emergency setting: predictors of epileptic mimic versus ischemic stroke. J Clin Neurosci 67:129–133
Quintas S, López Ruiz R, Trillo S, Gago-Veiga AB, Zapata-Wainberg G, Dotor García-Soto J, Ximénez-Carrillo Á, Vivancos J (2018) Clinical, imaging and electroencephalographic characterization of three cases of HaNDL syndrome. Cephalalgia 38(7):1402–1406
Spina R, Simon N, Markus R, Muller DW, Kathir K (2017) Contrast-induced encephalopathy following cardiac catheterization. Catheter Cardiovasc Interv 90(2):257–268
Stone J, Warlow C, Sharpe M (2012) Functional weakness: clues tomechanism from the nature of onset. J Neurol Neurosurg Psychiatry 83:67–69
Tsivgoulis G, Zand R, Katsanos AH, Goyal N, Uchino K, Chang J, Dardiotis E, Putaala J, Alexandrov AW, Malkoff MD, Alexandrov AV (2015) Safety of intravenous thrombolysis in stroke mimics: prospective 5‑year study and comprehensive meta-analysis. Stroke 46(5):1281–1287
Viana M, Afridi S (2018) Migraine with prolonged aura: phenotype and treatment. Naunyn Schmiedebergs Arch Pharmacol 391(1):1–7
Vilela P (2017) Acute stroke differential diagnosis: stroke mimics. Eur J Radiol 96:133–144
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Lakatos, LB., Christ, M., Müller, M. et al. „Stroke mimics“ – Differenzialdiagnose des Schlaganfalls in der Notfallmedizin. Notfall Rettungsmed 24, 990–996 (2021). https://doi.org/10.1007/s10049-021-00877-x
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DOI: https://doi.org/10.1007/s10049-021-00877-x