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Appropriate control time constant in relation to characteristics of the baroreflex vascular system in 1/R control of the total artificial heart

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  • Artificial Heart (Basic)
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Abstract

1/R control is a physiological control method of the total artificial heart (TAH) with which long-term survival was obtained with animal experiments. However, 1/R control occasionally diverged in the undulation pump TAH (UPTAH) animal experiment. To improve the control stability of the 1/R control, appropriate control time constant in relation to characteristics of the baroreflex vascular system was investigated with frequency analysis and numerical simulation. In the frequency analysis, data of five goats in which the UPTAH was implanted were analyzed with first Fourier transform technique to examine the vasomotion frequency. The numerical simulation was carried out repeatedly changing baroreflex parameters and control time constant using the elements-expanded Windkessel model. Results of the frequency analysis showed that the 1/R control tended to diverge when very low frequency band that was an indication of the vasomotion frequency was relative high. In numerical simulation, divergence of the 1/R control could be reproduced and the boundary curves between the divergence and convergence of the 1/R control varied depending on the control time constant. These results suggested that the 1/R control tended to be unstable when the TAH recipient had high reflex speed in the baroreflex vascular system. Therefore, the control time constant should be adjusted appropriately with the individual vasomotion frequency.

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Acknowledgements

This study was supported in part by the JSPS KAKENHI Grant Number 26253071. We thank Mathworks, Inc for numerical analysis and simulation with MATLAB.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Sora Mizuta, Itsuro Saito, Takashi Isoyama, Shintaro Hara, Terumi Yurimoto, Xinyang Li, Haruka Murakami, Toshiya Ono & Yusuke Abe

  2. Department of Information Physics and Computing, Graduate School of Information Science and Technology, The University of Tokyo, Tokyo, Japan

    Kunihiko Mabuchi

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  1. Sora Mizuta
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  2. Itsuro Saito
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  3. Takashi Isoyama
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  4. Shintaro Hara
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  5. Terumi Yurimoto
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  6. Xinyang Li
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  7. Haruka Murakami
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  8. Toshiya Ono
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  9. Kunihiko Mabuchi
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  10. Yusuke Abe
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Correspondence to Itsuro Saito or Yusuke Abe.

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Mizuta, S., Saito, I., Isoyama, T. et al. Appropriate control time constant in relation to characteristics of the baroreflex vascular system in 1/R control of the total artificial heart. J Artif Organs 20, 200–205 (2017). https://doi.org/10.1007/s10047-017-0965-6

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  • DOI: https://doi.org/10.1007/s10047-017-0965-6

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