Abstract
The aim of this study was to evaluate our clinical experience with the Jarvik 2000 axial flow pump (Jarvik Heart, Inc, New York, NY, USA), a miniature axial flow left ventricular assist device (LVAD). The clinical results of eight patients, who underwent LVAD implantation with the Jarvik 2000 (median age 55.0 years; six men) between 2005 and 2010, including two who participated in a multicenter clinical trial in Japan, were reviewed. Two patients underwent LVAD implantation as destination therapy. Four patients underwent Jarvik 2000 implantation via median sternotomy, while the other four underwent implantation via left thoracotomy. There were no major complications during surgery. Four patients were supported for more than 2 years. The longest support duration was 1,618 days. Six patients successfully bridged to heart transplantation after a median 725 days of support. One patient on destination therapy died of a cerebral infarction. The other patient on destination therapy had had the LVAD for 1,618 days. The overall survival rates at 1, 2, and 3 years were 100, 86, and 86 %, respectively. The median postoperative serum lactate dehydrogenase level was 860.5 U/L at 1 month, 735 U/L at 6 months, and 692 U/L at 1 year. There were no fatal device-related infections. We found that the Jarvik 2000 with pin bearing could support patients with end-stage heart failure with acceptable mortality and morbidity rates. Further evaluations of the prevalence of thromboembolic and hemolytic events in patients with the new conical-bearing Jarvik 2000 are required.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Frazier OH, Myers TJ, Gregoric ID, Khan T, Delgado R, Croitoru M, et al. Initial clinical experience with the Jarvik 2000 implantable axial-flow left ventricular assist system. Circulation. 2002;105:2855–60.
Siegenthaler MP, Martin J, van de Loo A, Doenst T, Bothe W, Beyersdorf F. Implantation of the permanent Jarvik-2000 left ventricular assist device: a single-center experience. J Am Coll Cardiol. 2002;39:1764–72.
Frazier OH, Myers TJ, Westaby S, Gregoric ID. Use of the Jarvik 2000 left ventricular assist system as a bridge to heart transplantation or as destination therapy for patients with chronic heart failure. Ann Surg. 2003;237:631–6.
Siegenthaler MP, Frazier OH, Beyersdorf F, Martin J, Laks H, Elefteriades J, et al. Mechanical reliability of the Jarvik 2000 Heart. Ann Thorac Surg. 2006;81:1752–8.
Haj-Yahia S, Birks EJ, Rogers P, Bowles C, Hipkins M, George R, et al. Midterm experience with the Jarvik 2000 axial flow left ventricular assist device. J Thorac Cardiovasc Surg. 2007;134:199–203.
Sorensen EN, Pierson RN 3rd. Feller ED, Griffith BP; University of Maryland surgical experience with the Jarvik 2000 axial flow ventricular assist device. Ann Thorac Surg. 2012;93:133–40.
Saito S, Sakaguchi T, Sawa Y. Clinical report of long-term support with dual Jarvik 2000 biventricular assist device. J Heart Lung Transplant. 2011;30:845–7.
Kamata S, Sakaguchi T, Miyagawa S, Yoshikawa Y, Yamauchi T, Takeda K, et al. The first clinical case in Japan of destination therapy using the Jarvik 2000 left ventricular assist device. J Artif Organs. 2010;13:170–3.
Kainuma S, Sakaguchi T, Saito S, Miyagawa S, Yoshikawa Y, Yamauchi T, et al. Implantation of a Jarvik 2000 left ventricular assist device as a bridge to eligibility for refractory heart failure with renal dysfunction. J Artif Organs. 2012;15:83–6.
Komoda T, Drews T, Hetzer R, Lehmkuhl HB. Lower body surface area is highly related to mortality due to stroke or systemic bleeding in patients receiving an axial flow blood pump as a left ventricular assist device. Eur J Cardiothorac Surg. 2013;43:1036–42.
Cabrera AG, Sundareswaran KS, Samayoa AX, Jeewa A, McKenzie ED, Rossano JW, et al. Outcomes of pediatric patients supported by the HeartMate II left ventricular assist device in the United States. J Heart Lung Transplant. 2013;32:1107–13.
Löffler C, Straub A, Bassler N, Pernice K, Beyersdorf F, Bode C, et al. Evaluation of platelet activation in patients supported by the Jarvik 2000* high-rotational speed impeller ventricular assist device. J Thorac Cardiovasc Surg. 2009;137:736–41.
Sakaguchi T, Matsumiya G, Yoshioka D, Miyagawa S, Nishi H, Yoshikawa Y, et al. DuraHeart™ magnetically levitated left ventricular assist device: Osaka University experience. Circ J. 2013;77:1736–41.
Saito S, Sakaguchi T, Miyagawa S, Nishi H, Yoshikawa Y, Fukushima S, et al. Jarvik 2000 biventricular assist device conversion from old pin-shaped bearing pumps to new conical bearing pumps. J Artif Organs. 2013;16:105–9.
Uriel N, Han J, Morrison KA, Nahumi N, Yuzefpolskaya M, Garan AR, et al. Device thrombosis in HeartMate II continuous-flow left ventricular assist devices: a multifactorial phenomenon. J Heart Lung Transplant. 2013;S1053–2498:01462–9.
Lalonde SD, Alba AC, Rigobon A, Ross HJ, Delgado DH, Billia F, et al. Clinical differences between continuous flow ventricular assist devices: a comparison between HeartMate II and HeartWare HVAD. J Card Surg. 2013;28:604–10.
Kato TS, Schulze PC, Yang J, Chan E, Shahzad K, Takayama H, et al. Pre-operative and post-operative risk factors associated with neurologic complications in patients with advanced heart failure supported by a left ventricular assist device. J Heart Lung Transplant. 2012;31:1–8.
Conflict of interest
Matsumiya Goro received a research grant from Century Medical Inc. All other authors have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yoshioka, D., Matsumiya, G., Toda, K. et al. Clinical results with Jarvik 2000 axial flow left ventricular assist device: Osaka University Experience. J Artif Organs 17, 308–314 (2014). https://doi.org/10.1007/s10047-014-0783-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10047-014-0783-z