Abstract
Purpose
To analyze the incisional hernia recurrence rate at a long-term follow-up using a biosynthetic long-term absorbable mesh in patients with a higher risk of surgical infection in a contaminated surgical field.
Methods
This was a retrospective multicentric study. All patients undergoing incisional hernia repair between 2016 and 2018 at 6 participating university centers were included. Patients were classified according to the Ventral Hernia Working Group (VHWG). All consecutive patients who underwent abdominal wall repair using biosynthetic long-term absorbable mesh (Phasix®) in contaminated fields (grade 3 and 4 of the VHWG classification) were included. Patients were followed-up until September 2021. Preoperative, operative, and postoperative data were collected. All patients’ surgical site infections (SSIs) and surgical site occurrences (SSOs) were recorded. The primary outcome of interest was the clinical incisional hernia recurrence rate.
Results
One hundred and eight patients were included: 77 with VHWG grade 3 (71.3%) and 31 with VHWG grade 4 (28.7%). Median time follow-up was 41 months [24; 63]. Twenty-four patients had clinical recurrence during the follow-up (22.2%). The SSI and SSO rates were 24.1% and 36.1%, respectively. On multivariate analysis, risk factors for incisional hernia recurrence were previous recurrence, mesh location, and postoperative enterocutaneous fistula.
Conclusions
At the 3 year follow-up, the recurrence rate with a biosynthetic absorbable mesh (Phasix®) for incisional hernia repair in high-risk patients (VHWG grade 3 and 4) seemed to be suitable (22.2%). Most complications occurred in the first year, and SSI and SSO rates were low despite high-risk VHWG grading.
Similar content being viewed by others
References
Luijendijk RW, Hop WC, van den Tol MP, de Lange DC, Braaksma MM, Ijzermans JN et al (2000) A comparison of suture repair with mesh repair for incisional hernia. N Engl J Med 343(6):392–398
Burger JWA, Luijendijk RW, Hop WCJ, Halm JA, Verdaasdonk EGG, Jeekel J (2004) Long-term follow-up of a randomized controlled trial of suture versus mesh repair of incisional hernia. Ann Surg 240(4):578–83 (discussion 583-585)
Mathes T, Walgenbach M, Siegel R (2016) Suture versus mesh repair in primary and incisional ventral hernias: a systematic review and meta-analysis. World J Surg 40(4):826–835
Kokotovic D, Bisgaard T, Helgstrand F (2016) Long-term recurrence and complications associated with elective incisional hernia repair. JAMA 316(15):1575–1582
Doussot A, Abo-Alhassan F, Derbal S, Fournel I, Kasereka-Kisenge F, Codjia T et al (2019) Indications and outcomes of a cross-linked porcine dermal collagen mesh (permacol) for complex abdominal wall reconstruction: a multicenter audit. World J Surg 43(3):791–797
Itani KMF, Rosen M, Vargo D, Awad SS, Denoto G, Butler CE et al (2012) Prospective study of single-stage repair of contaminated hernias using a biologic porcine tissue matrix: the RICH study. Surgery 152(3):498–505
Martin DP, Badhwar A, Shah DV, Rizk S, Eldridge SN, Gagne DH et al (2013) Characterization of poly-4-hydroxybutyrate mesh for hernia repair applications. J Surg Res 184(2):766–773
Scott JR, Deeken CR, Martindale RG, Rosen MJ (2016) Evaluation of a fully absorbable poly-4-hydroxybutyrate/absorbable barrier composite mesh in a porcine model of ventral hernia repair. Surg Endosc 30(9):3691–3701
van Rooijen MM, Jairam AP, Tollens T, Jørgensen LN, de Vries Reilingh TS, Piessen G et al (2020) Outcomes of a new slowly resorbable biosynthetic mesh (Phasix™) in potentially contaminated incisional hernias: a prospective, multi-center, single-arm trial. Int J Surg Lond Engl 83:31–36
Charleux-Muller D, Hurel R, Fabacher T, Brigand C, Rohr S, Manfredelli S et al (2021) Slowly absorbable mesh in contaminated incisional hernia repair: results of a French multicenter study. Hernia J Hernias Abdom Wall Surg 25(4):1051–1059
Deeken CR, Matthews BD (2013) Characterization of the mechanical strength, resorption properties, and histologic characteristics of a fully absorbable material (poly-4-hydroxybutyrate-PHASIX mesh) in a porcine model of hernia repair. ISRN Surg 2013:238067
Breuing K, Butler CE, Ferzoco S, Franz M, Hultman CS, Ventral Hernia Working Group et al (2010) Incisional ventral hernias: review of the literature and recommendations regarding the grading and technique of repair. Surgery 148(3):544–558
DeBord J, Novitsky Y, Fitzgibbons R, Miserez M, Montgomery A (2018) SSI, SSO, SSE, SSOPI: the elusive language of complications in hernia surgery. Hernia J Hernias Abdom Wall Surg 22(5):737–738
Dindo D, Demartines N, Clavien P-A (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213
Martin DP, Badhwar A, Shah DV, Rizk S, Eldridge SN, Gagne DH et al (2013) Characterization of poly-4-hydroxybutyrate mesh for hernia repair applications. J Surg Res 184(2):766–773
Rosen MJ, Krpata DM, Ermlich B, Blatnik JA (2013) A 5-year clinical experience with single-staged repairs of infected and contaminated abdominal wall defects utilizing biologic mesh. Ann Surg 257(6):991–996
Iacco A, Adeyemo A, Riggs T, Janczyk R (2014) Single institutional experience using biological mesh for abdominal wall reconstruction. Am J Surg 208(3):480–484 (discussion 483-484)
Buell JF, Sigmon D, Ducoin C, Shapiro M, Teja N, Wynter E et al (2017) Initial experience with biologic polymer scaffold (Poly-4-hydroxybuturate) in complex abdominal wall reconstruction. Ann Surg 266(1):185–188
Rosen MJ, Bauer JJ, Harmaty M, Carbonell AM, Cobb WS, Matthews B et al (2017) Multicenter, prospective, longitudinal study of the recurrence, surgical site infection, and quality of life after contaminated ventral hernia repair using biosynthetic absorbable mesh: the COBRA study. Ann Surg 265(1):205–211
Roth JS, Anthone GJ, Selzer DJ, Poulose BK, Pierce RA, Bittner JG et al (2021) Prospective, multicenter study of P4HB (Phasix™) mesh for hernia repair in cohort at risk for complications: 3 year follow-up. Ann Med Surg 2012(61):1–7
Van Rooijen MMJ, Tollens T, Jørgensen LN, de Vries Reilingh TS, Piessen G, Köckerling F et al (2021) Slowly resorbable biosynthetic mesh: 2 year results in VHWG grade 3 hernia repair. Hernia J Hernias Abdom Wall Surg 26:131-138
Claessen JJM, Timmer AS, Atema JJ, Boermeester MA (2021) Outcomes of mid-term and long-term degradable biosynthetic meshes in single-stage open complex abdominal wall reconstruction. Hernia J Hernias Abdom Wall Surg 25(6):1647–1657
Holihan JL, Bondre I, Askenasy EP, Greenberg JA, Keith JN, Martindale RG et al (2016) Sublay versus underlay in open ventral hernia repair. J Surg Res 202(1):26–32
Sosin M, Nahabedian MY, Bhanot P (2018) The perfect plane: a systematic review of mesh location and outcomes, update 2018. Plast Reconstr Surg 142(3 Suppl):107S-116S
Helgstrand F, Rosenberg J, Kehlet H, Jorgensen LN, Bisgaard T (2013) Nationwide prospective study of outcomes after elective incisional hernia repair. J Am Coll Surg 216(2):217–228
Köckerling F, Koch A, Lorenz R, Schug-Pass C, Stechemesser B, Reinpold W (2015) How long do we need to follow-up our hernia patients to find the real recurrence rate? Front Surg 2:24
Romain B, Renard Y, Binquet C, Poghosyan T, Moszkowicz D, Gillion J-F et al (2020) Recurrence after elective incisional hernia repair is more frequent than you think: an international prospective cohort from the French Society of Surgery. Surgery 168(1):125–134
Pereira JA, López-Cano M, Hernández-Granados P, Feliu X, en representación del grupo EVEREG (2016) Initial results of the national registry of incisional hernia. Cirugia Espanola 94(10):595–602
Bloemen A, van Dooren P, Huizinga BF, Hoofwijk AGM (2012) Comparison of ultrasonography and physical examination in the diagnosis of incisional hernia in a prospective study. Hernia J Hernias Abdom Wall Surg 16(1):53–57
Kroese LF, Sneiders D, Kleinrensink GJ, Muysoms F, Lange JF (2018) Comparing different modalities for the diagnosis of incisional hernia: a systematic review. Hernia J Hernias Abdom Wall Surg 22(2):229–242
Author information
Authors and Affiliations
Contributions
All authors have approved the manuscript and meet the requirements for authorship.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interest. P Ortega Deballon received grants from Covidien/Medtronic, LifeCell/Acelity and Bard/Beckton-Dickinson within the past 5 years. V Dubuisson received grants from Bard/Beckton-Dickinson and LifeCell/Acelity within the past 5 years. Y Renard received grants from BD(r), LifeCell/Acelity and Hartmann within the past 5 years.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Layer, T., Benammi, S., Dubuisson, V. et al. Incisional hernia repair with a slowly absorbable P4HB mesh: what happens after the mesh disappears? A retrospective longitudinal clinical study. Hernia 27, 387–394 (2023). https://doi.org/10.1007/s10029-022-02616-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10029-022-02616-8