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An electrochemical sensor based on SiO2@TiO2-embedded molecularly imprinted polymers for selective and sensitive determination of theophylline

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Abstract

The present work is focused on a typical core-shell-structured SiO2@TiO2-based imprinted polymer composite, employed as a molecular recognition and sensing interface in the construction of an innovative electrochemical sensor. Herein, the methacrylic acid and a bronchodilator drug, theophylline, were used as functional monomer and template, respectively. The SiO2@TiO2 served as a potential signal transducer to shuttle electrons between the binding sites and the electrode. Such modification induced an electrocatalytic effect and thereby greatly improved the electrode kinetics. The analytical features of the developed theophylline sensor have been accessed, and the results have indicated that an increase of differential pulse voltammetric current as compared to the corresponding traditional imprinted polymer modified electrode. Moreover, the sensor has showed high sensitivity, wider linear range (0.01–40 μM), lower detection limit (1.2 nM), and satisfactory long-term stability, which was validated with the complex matrices of tea, human blood serum, and urine, without any matrix effect and cross-reactivity.

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Acknowledgements

The authors gratefully acknowledge the financial support received from the National Science Foundation of China (No. 61201091), the Program for Science & Technology Innovation Talents in University of Henan Province (No. 16HASTIT004), the Key Scientific and Technological Project of Henan Province (No. 162102210126), the Key Scientific Research Projects in University of Henan Province (No. 18A150047), the Plan for Scientific Innovation Talent of Henan Province (No. 2017JR0016), the open fund of Henan Key Laboratory of Biomolecular Recognition and Sensing (No. HKLBRSK1602), the open fund of Key Laboratory of Analytical Chemistry for Biology and Medicine (ACBM2016005), and Nanhu Scholars Program for Young Scholars of XYNU.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering & Institute for Conservation and Utilization of Agro−bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, People’s Republic of China

    Tian Gan, Aixia Zhao, Zhikai Wang, Pan Liu, Junyong Sun & Yanming Liu

  2. Henan Key Laboratory of Biomolecular Recognition and Sensing, Shangqiu Normal University, Shangqiu, 476000, People’s Republic of China

    Tian Gan & Yanming Liu

  3. Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Wuhan University, Wuhan, 430072, People’s Republic of China

    Tian Gan

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  1. Tian Gan
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  2. Aixia Zhao
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  3. Zhikai Wang
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  4. Pan Liu
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  5. Junyong Sun
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  6. Yanming Liu
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Correspondence to Tian Gan or Yanming Liu.

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Gan, T., Zhao, A., Wang, Z. et al. An electrochemical sensor based on SiO2@TiO2-embedded molecularly imprinted polymers for selective and sensitive determination of theophylline. J Solid State Electrochem 21, 3683–3691 (2017). https://doi.org/10.1007/s10008-017-3713-1

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  • DOI: https://doi.org/10.1007/s10008-017-3713-1

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