Skip to main content
SpringerLink
Log in

Does active decompression of odontogenic keratocyst change the histologic diagnosis?

  • Original Article
  • Published:
Oral and Maxillofacial Surgery Aims and scope Submit manuscript

Abstract

Aim

The purpose of this study was to compare the histopathologic findings of pre- and post-active decompression of odontogenic keratocyst and to establish if such findings were consistent.

Materials and methods

A retrospective case series from a group of patients diagnosed with odontogenic keratocyst who underwent active decompression and distraction sugosteogenesis followed by final enucleation was designed and implemented. The dependent variable was changed in histologic diagnosis, as evaluated by an oral and maxillofacial pathologist. Other variables included age, gender, anatomic location of the lesion, and time elapsed from initial biopsy to final enucleation.

Results

Six patients diagnosed with odontogenic keratocyst who underwent active decompression followed by enucleation and curettage were studied. The mean age was 45.6 years (range, 16 to 74) 83.33% were males, 16.66 females. Lesions were located in the mandible in 83.33% of cases and in the maxilla in 16.66% of cases. Post-active decompression histologic examination at the time of definitive enucleation was consistent with the initial diagnosis in 83.33% of cases.

Conclusions

The histopathological diagnosis at the time of definitive treatment by enucleation and curettage is consistent with the pre-active decompression diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Toller PA (1970) The osmolality of fluids from cysts of the jaws. Br Dent J 129:275–278

    Article  CAS  Google Scholar 

  2. Harris M (1978) Odontogenic cyst growth and prostaglandin induced bone resorption. Ann R Coll Surg Engl 60:85–91

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Ninomlya T, Kubota Y, Koji T, Shirasuna K (2002) Marsupialization inhibits interleukin-1α expression and epithelial cell proliferation in odontogenic cysts. J Oral Pathol Med 31:526–533

    Article  Google Scholar 

  4. Partsch C (1892) Uber kiefercysten. Dtsch Mschr Zahnheilkd 10:271

    Google Scholar 

  5. Partsch C (1910) Zur behandlung der kieferzysten. Dtsch Mschr Zahnheilkd 28:252–260

    Google Scholar 

  6. Neuschmidt V (1942) Drainierungs-Methode der Kieferzysten. Dtsch Zahnärztl Wschr 21:287

    Google Scholar 

  7. Thomas EH (1947) Cysts of the jaws; saving involved vital teeth by tube drainage. J Oral Surg 5:1–9

    CAS  PubMed  Google Scholar 

  8. Thoma KH (ed) (1958) Oral surgery, 3rd edn. Mosby, St Louis, pp 1033–1036

  9. Castro-Núñez J (2016) An innovative decompression device to treat odontogenic cysts. J Craniofac Surg 27:1316

    Article  Google Scholar 

  10. Castro-Núñez J, Rey D, Amaya L (2017) An innovative intracystic negative pressure system to treat odontogenic cysts. J Craniofac Surg 28:1883–1884

    Article  Google Scholar 

  11. Castro-Núñez J (2018) Active intracystic negative pressure could induce osteogenesis. J Craniofac Surg 29:e370–e371

    Article  Google Scholar 

  12. Castro-Núñez J (2018) Distraction sugosteogenesis: its biologic bases and therapeutic principles. J Craniofac Surg 29:2088–2095

    Article  Google Scholar 

  13. Moreno-Rodríguez P, Rodríguez LM, Gómez-Delgado A, et al (2021) Active decompression and distraction sugosteogenesis for the treatment of calcifying odontogenic cyst. Oral Maxillofac Surg 25:89–97

  14. Panders AK, Hadders HN (1969) Solitary keratocysts of the jaws. J Oral Surg 2:931

    Google Scholar 

  15. Schlieve T, Miloro M, Kolokythas A (2014) Does decompression of odontogenic cysts and cystlike lesions change the histologic diagnosis? J Oral Maxillofac Surg 72:1094

    Article  Google Scholar 

  16. Browne RM (1971) The odontogenic keratocyst: histological features and their correlation with clinical behavior. Br Dent J 131:249

    Article  CAS  Google Scholar 

  17. Brannon RB (1977) The odontogenic keratocyst. A clinicopathologic study of 312 cases. Part II. Histologic features. Oral Surg 43:233

    Article  CAS  Google Scholar 

  18. Hodgkinson DJ, Woods JE, Dahlin DC, Tolman DE (1978) Keratocysts of the jaws. Clinicopathologic study of 79 patients. Cancer 41:803

    Article  CAS  Google Scholar 

  19. Partridge M, Towers JF (1987) The primordial cyst (odontogenic keratocyst): its tumour-like characteristics and behaviour. Br J Oral Maxillofac Surg 25:271

    Article  CAS  Google Scholar 

  20. Rodu B, Tate AL, Martínez MG Jr (1987) The implication of inflammation in odontogenic keratocysts. J Oral Pathol 16:518

    Article  CAS  Google Scholar 

  21. Brøndum N, Jensen VJ (1991) Recurrence of keratocysts and decompression treatment. A long term follow up of forty-four cases. Oral Surg Oral Med Oral Pathol 72:265

    Article  Google Scholar 

  22. Marker P, Brøndum N, Clausen PP et al (1996) Treatment of large odontogenic keratocysts by decompression and later cystectomy: a long-term follow-up and a histologic study of 23 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82:122

    Article  CAS  Google Scholar 

  23. August M, Faquin WC, Troulis MJ et al (2003) Dedifferentiation of odontogenic keratocystic epithelium after cyst decompression. J Oral Maxillofac Surg 61:678

    Article  Google Scholar 

  24. Moreno-Rodriguez P, Bustillo-Rojas J, Guerrero LM et al (2019) Epithelial modulation of a calcifying odontogenic cyst after active decompression. Clin Oral Sci Dent 2:1–7

    Google Scholar 

  25. Consolo U, Setti G, Tognacci S et al (2020) Histological changes in odontogenic parakeratinized keratocysts treated with marsupialization followed by enucleation. Med Oral Patol Oral Cir Bucal 25:e827–e833

    Article  CAS  Google Scholar 

  26. Castro-Núñez J (2016) Decompression of odontogenic cystic lesions: past, present, and future. J Oral Maxillofac Surg 74(104):e1-9

    Google Scholar 

  27. Awni S, Conn B (2017) Decompression of keratocystic odontogenic tumors leading to increased fibrosis, but without any change in epithelial proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol 123:634–644

    Article  Google Scholar 

  28. August M, Faquin WC, Troulis M et al (2000) Dedifferentiation of odontogenic keratocyst from nonkeratinizing cyst by use of fine-needle aspiration biopsy and cytokeratin-10 staining. J Oral Maxillofac Surg 58:935

    Article  CAS  Google Scholar 

  29. Kuroyanagi N, Sakuma H, Miyabe S et al (2009) Prognostic factors for keratocystic odontogenic tumor (odontogenic keratocyst): analysis of clinic-pathologic and immunohistochemical findings in cysts treated by enucleation. J Oral Pathol Med 38:386–392

    Article  Google Scholar 

  30. Pogrel MA, Jordan RC (2004) Marsupialization as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg 62:651

    Article  Google Scholar 

Download references

Acknowledgements

The authors wish to express their gratitude to professors Augusto Elias Boneta and Sona Rivas-Tumanyan for their assistance during the preparation of this research project.

Author information

Authors and Affiliations

  1. Oral and Maxillofacial Surgery Residency Program, School of Dental Medicine, University of Puerto Rico – Medical Sciences Campus, Paseo Dr. José Celso Barbosa, San Juan, 00921, Puerto Rico

    Jaime Castro-Núñez, Andrés Gustavo Wiscovitch, Juan Pablo Porte, Bonifacio Rivera & Lidia M. Guerrero

  2. Oral and Maxillofacial Pathology Department, School of Dental Medicine, University of Puerto Rico – Medical Sciences Campus, San Juan, Puerto Rico

    José Wiscovitch

Authors
  1. Jaime Castro-Núñez
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrés Gustavo Wiscovitch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Juan Pablo Porte
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. José Wiscovitch
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Bonifacio Rivera
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Lidia M. Guerrero
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jaime Castro-Núñez.

Ethics declarations

Ethical approval

Approved by Institutional Review Board.

Informed consent

Informed consent was obtained.

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Castro-Núñez, J., Wiscovitch, A.G., Porte, J.P. et al. Does active decompression of odontogenic keratocyst change the histologic diagnosis?. Oral Maxillofac Surg 26, 291–298 (2022). https://doi.org/10.1007/s10006-021-00994-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10006-021-00994-4

Keywords

Search

Navigation