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Bone healing at collagenated bicortically installed implants: an experimental study in rabbits

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Abstract

Purpose

To study the healing at collagenated bicortically installed implants.

Methods

Twenty albino New Zealand rabbits were used for implant installation. Two implants with a double acid etched surface, coated with a collagen type I or left uncoated, were installed bicortically in the metaphysis and in the diaphysis of each tibia. Ten rabbits were euthanized after 2 weeks and ten after 6 weeks after installation. Ground sections were prepared for histological analyses that were performed both in the cortical layers and in the marrow regions.

Results

After 2 weeks of healing, highest amounts of new bone were found at the collagenated implants (43.2 ± 6.0%) compared to the standard implants (33.9 ± 6.1%; p = 0.022). After 6 weeks of healing, similar percentages of new bone were observed, being 51.8 ± 7.3% and 50.9 ± 9.6% (p = 0.678) for the standard and collagenated surfaces, respectively.

Conclusions

A coated surface with collagen type I promoted bone apposition in the earliest periods of healing. However, the effect vanished over time so that similar results were obtained after 6 weeks of healing.

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Acknowledgments

This study has been supported by a grant from LEADER MEDICA, Padua, Italy, and by ARDEC Academy, Rimini, Italy.

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Authors and Affiliations

  1. ARDEC Academy, viale Giovanni Pascoli 67, Rimini, Italy

    Luigi Feletto, Riccardo Favero & Daniele Botticelli

  2. Faculty of Dentistry, University of Medical Science, La Habana, Cuba

    Franco Bengazi & Joaquín Juan Urbizo Velez

  3. ARDEC Foundation, Cartagena de Indias, Colombia

    Mauro Ferri

Authors
  1. Luigi Feletto
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  2. Franco Bengazi
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  3. Joaquín Juan Urbizo Velez
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  4. Mauro Ferri
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  5. Riccardo Favero
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  6. Daniele Botticelli
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Corresponding author

Correspondence to Daniele Botticelli.

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Feletto, L., Bengazi, F., Urbizo Velez, J.J. et al. Bone healing at collagenated bicortically installed implants: an experimental study in rabbits. Oral Maxillofac Surg 24, 501–507 (2020). https://doi.org/10.1007/s10006-020-00882-3

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  • DOI: https://doi.org/10.1007/s10006-020-00882-3

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