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The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients

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Abstract

Objective

Dry-mouth patients use different interventions to relieve their oral dryness. As recent studies showed that various subgroups of dry-mouth patients perceived different intra-oral regions as most dry, the present study investigated whether the use of dry-mouth interventions by various subgroups of dry-mouth patients was related to the perceived oral dryness as well as salivary flow rate.

Materials and methods

Xerostomia Inventory (XI) scores, Regional Oral Dryness Score (RODI) scores and used dry-mouth interventions were extracted from the medical records of 528 patients visiting a saliva clinic. Based on their medical history, they were allocated into 6 subgroups.

Results

The subgroups of dry-mouth patients used a wide range of interventions to relieve their oral dryness. Sjögren’s syndrome patients used most interventions more frequently than patients with oral dryness due to use of a limited number of medications and controls. Patients using medications showed associations between the total XI score and dry-mouth interventions aimed at the entire mouth. In medication using patients and controls, the locally applied intervention “using mouth gel” was associated with RODI scores of the anterior tongue.

Conclusion

The use of dry-mouth interventions was associated with dry-mouth feelings. Use of interventions aimed to relieve dryness of the entire mouth was significantly associated with total XI score, while locally applied interventions were significantly associated with the severity of dryness at specific intra-oral regions, the anterior tongue in particular.

Clinical relevance

The results will help clinicians to advise dry-mouth patients about the most suitable interventions for relief of oral dryness complaints.

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Funding

This study was financially supported by an unrestricted grant from the Nederlands Tijdschrift voor Tandheelkunde (grant number OZB2018.01).

Author information

Authors and Affiliations

  1. Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Gustav Mahlerlaan, 3004, 1081 LA, Amsterdam, The Netherlands

    Z. Assy, H. S. Brand, C. P. Bots & F. J. Bikker

  2. Saliva Clinic of the Dutch Institute for Salivary Research, Bunschoten, Netherlands

    C. P. Bots

Authors
  1. Z. Assy
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  2. H. S. Brand
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  4. F. J. Bikker
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Contributions

All authors contributed to the conception and design of the study. Material preparation, data collection and analysis were performed by Z. Assy. The first draft of the manuscript was written by Z. Assy, and all authors commented on successive versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Z. Assy.

Ethics declarations

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Ethics Review Committee of the Academic Centre for Dentistry Amsterdam, protocol number 201951) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

For this type of study, formal consent is not required.

Conflict of interest

Z. Assy has received a research grant from the Nederlands Tijdschrift voor Tandheelkunde (NTVT). H.S. Brand declares that he has no conflict of interest. C.P. Bots declares that she has no conflict of interest. F.J. Bikker declares that he has no conflict of interest.

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Assy, Z., Brand, H.S., Bots, C.P. et al. The relationship between the severity of oral dryness and the use of dry-mouth interventions by various subgroups of dry-mouth patients. Clin Oral Invest 26, 3097–3108 (2022). https://doi.org/10.1007/s00784-021-04292-x

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  • DOI: https://doi.org/10.1007/s00784-021-04292-x

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