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Efficacy of periodontal minimally invasive surgery with and without regenerative materials for treatment of intrabony defect: a randomized clinical trial

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Abstract

Objectives

The minimally invasive surgical technique was modified in suture (MISTms) in this study. The trial was to determine the efficacy of MISTms with and without regenerative materials for the treatment of intrabony defect and to identify factors influencing 1-year clinical attachment level (CAL) gain.

Methods

Thirty-six patients with interdental intrabony defects were randomly assigned to MISTms (MISTms alone, 18) or MISTms plus deproteinized bovine bone mineral and collagen membrane (MISTms combined, 18). Wound healing was evaluated by early healing index (EHI) at 1, 2, 3, and 6 weeks. Probing depth (PD), CAL, gingival recession, radiographic defect depth, and distance from the base of defect to the cementoenamel junction were recorded at baseline and 1 year postoperatively. A one-year composite outcome measure based on the combination of CAL gain and post-surgery PD was evaluated. Factors influencing 1-year CAL gain were analyzed.

Results

Fifteen patients in MISTms-alone and 16 in the MISTms-combined group finished the study. The MISTms-alone group showed significantly better wound healing at 1 week. CAL significantly gained in the MISTms-alone and MISTms-combined group, with 2.53 ± 1.80 mm and 2.00 ± 1.38 mm respectively. The radiographic bone gain was 3.00 ± 1.56 mm and 3.85 ± 1.69 mm respectively. However, there were no significant differences between the two groups about 1-year outcomes. Lower EHI (optimal wound healing) and more baseline CAL positively influenced 1-year CAL gain.

Conclusions

MISTms is an effective treatment for intrabony defects. The regenerative materials do not show an additional effect on 1-year outcomes. Early wound healing and baseline CAL are factors influencing 1-year CAL gain.

Clinical relevance

MISTms with and without regenerative materials are both effective treatments for intrabony defect.

Trial registration

ClinicalTrials.gov Identifier: ChiCTR2100043272

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Funding

This study was funded by the Beijing Municipal Commission of Science and Technology (Z141107002514059).

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Authors and Affiliations

  1. Department of Periodontology, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, People’s Republic of China

    Bei Liu, Xiangying Ouyang, Jun Kang, Shuangying Zhou, Chao Suo, Lingqiao Xu, Jianru Liu & Wenyi Liu

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  1. Bei Liu
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  2. Xiangying Ouyang
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  3. Jun Kang
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  4. Shuangying Zhou
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  5. Chao Suo
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  6. Lingqiao Xu
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  7. Jianru Liu
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  8. Wenyi Liu
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Contributions

All authors have made substantial contributions to the study. Bei Liu contributed with data analysis, data interpretation, and manuscript drafting. Xiangying Ouyang designed the study and treated patients. Jun Kang performed the clinical evaluation. Shuangying Zhou performed a radiographic evaluation. Chao Suo and Lingqiao Xu contributed to data entry and verification. Jianru Liu performed randomization. Wenyi Liu assisted for study organization.

Corresponding author

Correspondence to Xiangying Ouyang.

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Ethical approval

The Ethics Committee of Peking University School and Hospital of Stomatology approved the study protocol (PKUSSIRB-2012080). The trial was registered at the Chinese Clinical Trial Registry (ChiCTR2100043272). All procedures involving human participants were performed in accordance with the ethical principles of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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All participants included in the study signed the informed consent.

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The authors declare no competing interests.

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Liu, B., Ouyang, X., Kang, J. et al. Efficacy of periodontal minimally invasive surgery with and without regenerative materials for treatment of intrabony defect: a randomized clinical trial. Clin Oral Invest 26, 1613–1623 (2022). https://doi.org/10.1007/s00784-021-04134-w

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