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Palatal growth changes in newborns with unilateral and bilateral cleft lip and palate from birth until 12 months after early neonatal cheiloplasty using morphometric assessment

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Abstract

Objectives

To compare palatal growth changes in infants with complete unilateral (UCLP) or bilateral (BCLP) cleft lip and palate during the first year of life.

Materials and methods

Upper dental arches of 68 neonates with UCLP and BCLP were evaluated using 2D and 3D morphometry based on dental casts obtained in two age categories (T0 before early neonatal cheiloplasty—UCLP 4 ± 3 days, BCLP 6 ± 5 days; T1 before palatoplasty—UCLP 10 ± 2 months, BCLP 12 ± 3 months).

Results

Intensive palatal growth was manifested in both directions of the palate. Palatal growth in the anterior direction was not restricted, despite the intercanine (CC´) and anterior (LL´) widths being significantly narrowed in the BCLP group (CC´ p = 0.019, LL´ p = 0.009). The posterior dental arches were significantly enlarged (UCLP p ≤ 0.001; BCLP p ≤ 0.001). The negative effect of cleft severity on palatal length was not confirmed (p = 0.802). Variability of the palate was immense mainly in BCLP infants (T0); however, it decreased in both cleft types, confirming the formative effect of palatal growth leading to alveolar cleft closure (UCLP p ≤ 0.001; BCLP p = 0.006 on the right, 0.005 on the left).

Conclusions

Both analyzed cleft groups (UCLP, BCLP) grew favorably during the first year of life, and the palatal growth was not limited in any direction.

Clinical relevance

Geometric morphometry allowed a comprehensive analysis of the palate, which can contribute to the improvement of surgical methods.

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Authors and Affiliations

  1. Department of Anthropology and Human Genetics, Faculty of Science, Charles University, Viničná 7, 128 43, Prague 2, Czech Republic

    Lenka Kožejová Jaklová, Eva Hoffmannová, Ján Dupej & Jana Velemínská

  2. Department of Software and Computer Science Education, Faculty of Mathematics and Physics, Charles University, Malostranské Náměstí 25, 118 00, Prague 1, Czech Republic

    Ján Dupej

  3. Department of Otorhinolaryngology, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, 150 00, Prague 5, Czech Republic

    Jiří Borský

  4. ENT, Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, 150 00, Prague 5, Czech Republic

    Michal Jurovčík

  5. Department of Neonatology with NICU, Obstetrics and Gynecology Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, V Úvalu 84, 150 00, Prague 5, Czech Republic

    Miloš Černý

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  1. Lenka Kožejová Jaklová
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Correspondence to Lenka Kožejová Jaklová.

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Kožejová Jaklová, L., Hoffmannová, E., Dupej, J. et al. Palatal growth changes in newborns with unilateral and bilateral cleft lip and palate from birth until 12 months after early neonatal cheiloplasty using morphometric assessment. Clin Oral Invest 25, 3809–3821 (2021). https://doi.org/10.1007/s00784-020-03711-9

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