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Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review

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Abstract

Objective

To critically appraise available literature concerning the effect of cyanoacrylate tissue adhesive (CTA) in postoperative palatal pain management.

Materials and methods

Electronic databases (Cochrane, PubMed, LILACS, Scopus, and Web of Science) were searched, complemented with grey literature databases up to June 2020. Studies reporting the effect of cyanoacrylate tissue adhesive compared to any other methods in postoperative palatal pain management were considered eligible. The risk of bias among and across included studies was assessed.

Results

Finally, four studies were considered eligible. Regarding free gingival graft (FGG), cyanoacrylate tissue adhesive with hemostatic sponge promoted less postoperative pain (PP) and analgesic consumption (AC). Also, cyanoacrylate tissue adhesive with platelet-rich fibrin produced less PP and more wound healing at the palatal area than cyanoacrylate tissue adhesive and wet gauze. Additionally, cyanoacrylate tissue adhesive promoted less PP and AC than wet gauze and suture. Concerning connective tissue graft (CTG), cyanoacrylate tissue adhesive, and suture produced similar PP, AC, and willingness for retreatment.

Conclusions

Based on the low certainty level, cyanoacrylate tissue adhesive appears to promote less PP and AC than wet gauze and suture regarding FGG. Additionally, cyanoacrylate tissue adhesive appears to increase the effect of hemostatic sponge, contributing to the reduction of PP and AC. Regarding CTG, cyanoacrylate tissue adhesive appears to promote similar PP, AC, and willingness for retreatment than the suture. Therefore, cyanoacrylate tissue adhesive has shown promising usefulness for PP management in FGG, but not a clear benefit for CTG.

Clinical relevance

The adoption of different agents for the protection of the palatal donor site following gingival harvesting procedures may provide better comfort to the patient.

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Acknowledgments

The authors thank Ms. Maria Gorete Manteguti Savi for the instructions regarding the search strategy construction.

Funding

This study was not supporter by any funding.

Patrícia Pauletto is supported with scholarship by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) (Coordination for the Improvement of Higher Education Personnel), Brazil.

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Authors and Affiliations

  1. Department of Dentistry, Center for Education and Research on Dental Implants, Federal University of Santa Catarina, Florianópolis, Brazil

    Mario Escobar, Cesar Augusto Magalhães Benfatti & Ariadne Cristiane Cabral Cruz

  2. Department of Dentistry, Brazilian Centre for Evidence-Based Research, Federal University of Santa Catarina, Florianópolis, Brazil

    Patrícia Pauletto

  3. Laboratory of Applied Virology, Federal University of Santa Catarina, Florianópolis, Brazil

    Ariadne Cristiane Cabral Cruz

  4. Faculty of Medicine and Dentistry, Department of Dentistry, University of Alberta, Edmonton, Alberta, Canada

    Carlos Flores-Mir

  5. Ceramic and Composite Materials Research Group, Federal University of Santa Catarina, Florianópolis, Brazil

    Bruno Alexandre Pacheco Castro Henriques

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Contributions

Mario Escobar, Patrícia Pauletto, Cesar Augusto Magalhães Benfatti, Ariadne Cristiane Cabral Cruz, Carlos Flores-Mir, and Bruno Alexandre Pacheco Castro Henriques contributed to the conception and the design of the study; Mario Escobar, Patrícia Pauletto, and Ariadne Cristiane Cabral Cruz collected the data; Mario Escobar, Patrícia Pauletto, and Ariadne Cristiane Cabral Cruz analyzed the data; and Mario Escobar, Patrícia Pauletto, Cesar Augusto Magalhães Benfatti, Ariadne Cristiane Cabral Cruz, Carlos Flores-Mir, and Bruno Alexandre Pacheco Castro Henriques drafted and critically revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ariadne Cristiane Cabral Cruz.

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Conflict of interest

Mario Escobar declares that he has no conflict of interest. Patrícia Pauletto declares that she has no conflict of interest. Cesar Augusto Magalhães Benfatti declares that he has no conflict of interest. Ariadne Cristiane Cabral Cruz declares that she has no conflict of interest. Carlos Flores-Mir declares that he has no conflict of interest. Bruno Alexandre Pacheco Castro Henriques declares that he has no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Escobar, M., Pauletto, P., Benfatti, C.A.M. et al. Effect of cyanoacrylate tissue adhesive in postoperative palatal pain management: a systematic review. Clin Oral Invest 25, 3609–3622 (2021). https://doi.org/10.1007/s00784-020-03683-w

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  • DOI: https://doi.org/10.1007/s00784-020-03683-w

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